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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transplantologiya</journal-id><journal-title-group><journal-title xml:lang="ru">Трансплантология</journal-title><trans-title-group xml:lang="en"><trans-title>Transplantologiya. The Russian Journal of Transplantation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-0506</issn><issn pub-type="epub">2542-0909</issn><publisher><publisher-name>IPO Association of Transplantologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23873/2074-0506-2025-17-3-309-317</article-id><article-id custom-type="elpub" pub-id-type="custom">transplantologiya-1035</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Клинический случай успешного лечения инфекции области хирургического вмешательства у реципиента почки и поджелудочной железы</article-title><trans-title-group xml:lang="en"><trans-title>A clinical case of successful treatment of surgical site infection in a kidney and pancreas recipient</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0746-1884</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хубутия</surname><given-names>М. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Khubutiya</surname><given-names>M. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Могели Шалвович Хубутия - акад. РАН, проф., д-р мед. наук, президент ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; заведующий кафедрой трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «Российский университет медицины» МЗ РФ</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p><p>127006, Москва, Долгоруковская ул., д. 4</p></bio><bio xml:lang="en"><p>Mogeli Sh. Khubutiya - Academician of the Russian Academy of Sciences, Prof., Dr. Sci. (Med.), President of N.V. Sklifosovsky Research Institute for Emergency Medicine; Head of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p><p>4 Dolgorukovskaya St., Moscow 127006</p></bio><email xlink:type="simple">khubutiyams@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0156-2107</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавель</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravel</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никита Сергеевич Журавель - канд. мед. наук, врач хирург, младший научный сотрудник отделения трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ассистент кафедры трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «Российский университет медицины»</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p><p>127006, Москва, Долгоруковская ул., д. 4</p></bio><bio xml:lang="en"><p>Nikita S. Zhuravel - Cand. Sci. (Med.), Surgeon, Senior Researcher, Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Teaching Assistant of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p><p>4 Dolgorukovskaya St., Moscow 127006</p></bio><email xlink:type="simple">zhuravelns@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8199-905X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмарина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmarina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нонна Валерьевна Шмарина - канд. мед. наук, старший научный сотрудник отделения трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов им. В.П. Демихова МБФ ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Nonna V. Shmarina - Cand. Sci. (Med.), Senior Researcher, Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the V.P. Demikhov Department of Transplantation and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University)</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p><p>1 Ostrovityanov St., Moscow 117997</p></bio><email xlink:type="simple">shmarinanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1396-7048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балкаров</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Balkarov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аслан Галиевич Балкаров - канд. мед. наук, заведующий научным отделением трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов им. В.П. Демихова МБФ ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ; заведующий организационно-методическим отделом по трансплантологии ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p><p>117997, Москва, ул. Островитянова, д. 1</p><p>115184, Москва, Большая Татарская ул., д. 30</p></bio><bio xml:lang="en"><p>Aslan G. Balkarov - Cand. Sci. (Med.), Head of the Scientific Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the V.P. Demikhov Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University); Head of the Organizational and Methodological Department for Transplantology, Research Institute for Healthcare Organization and Medical Management</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p><p>1 Ostrovityanov St., Moscow 117997</p><p>30 Bolshaya Tatarskaya St., Moscow 115184</p></bio><email xlink:type="simple">balkarovag@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5731-3310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Илья Викторович Дмитриев - д-р мед. наук, заведующий отделением трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов им. В.П. Демихова МБФ ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Ilya V. Dmitriev - Dr. Sci. (Med.), Head of the Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the V.P. Demikhov Department of Transplantation and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University)</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p><p>1 Ostrovityanov St., Moscow 117997</p></bio><email xlink:type="simple">dmitrieviv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7953-8182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сторожев</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Storozhev</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Роман Васильевич Сторожев - врач хирург отделения трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Roman V. Storozhev - Surgeon, Department of Kidney and Pancreas Transplantation</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p></bio><email xlink:type="simple">storozhevrv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0473-9932</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ксения Евгеньевна Лазарева - канд. мед. наук, врач эндокринолог, научный сотрудник отделения трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «Российский университет медицины» МЗ РФ</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p><p>127006, Москва, Долгоруковская ул., д. 4</p></bio><bio xml:lang="en"><p>Kseniya E. Lazareva - Cand. Sci. (Med.), Endocrinologist, Research Associate, Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p><p>4 Dolgorukovskaya St., Moscow 127006</p></bio><email xlink:type="simple">lazarevake2@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «Российский университет медицины» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; V.P. Demikhov Department of Transplantation and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет); ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; V.P. Demikhov Department of Transplantation and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University); Research Institute for Healthcare Organization and Medical Management</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>09</month><year>2025</year></pub-date><volume>17</volume><issue>3</issue><fpage>309</fpage><lpage>317</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хубутия М.Ш., Журавель Н.С., Шмарина Н.В., Балкаров А.Г., Дмитриев И.В., Сторожев Р.В., Лазарева К.Е., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Хубутия М.Ш., Журавель Н.С., Шмарина Н.В., Балкаров А.Г., Дмитриев И.В., Сторожев Р.В., Лазарева К.Е.</copyright-holder><copyright-holder xml:lang="en">Khubutiya M.S., Zhuravel N.S., Shmarina N.V., Balkarov A.G., Dmitriev I.V., Storozhev R.V., Lazareva K.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jtransplantologiya.ru/jour/article/view/1035">https://www.jtransplantologiya.ru/jour/article/view/1035</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Инфекции области хирургического вмешательства после трансплантации любого солидного органа очень опасны, поскольку могут привести к утрате трансплантата и смерти реципиента. Их лечение представляет чрезвычайную сложность и требует постоянных исследований и адаптации протоколов лечения для улучшения результатов.</p></sec><sec><title>Цель</title><p>Цель. Демонстрация случая эффективного лечения инфекции забрюшинного пространства в области хирургического вмешательства после сочетанной трансплантации почки и поджелудочной железы (СТПиПЖ) в области расположения трансплантата поджелудочной железы (ТПЖ).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Реципиент почки и поджелудочной железы (ПЖ) – женщина, 31 год, в анамнезе сахарный диабет 1-го типа, осложненный диабетической нефропатией до 5 стадии хронической болезни почек. При описании клинического случая были использованы результаты общеклинических и инструментальных исследований из истории болезни и карты наблюдения реципиента и паспорта органа.</p></sec><sec><title>Результаты</title><p>Результаты. Представлена клиническая картина течения бактериальной инфекции забрюшинного пространства в области расположения ТПЖ и ее успешного лечения у реципиента после СТПиПЖ. Благодаря выбору оптимальной тактики лечения удалось не только избежать развития сепсиса, но и сохранить функцию обоих трансплантатов.</p></sec><sec><title>Заключение</title><p>Заключение. При развитии инфекции области хирургического вмешательства в виде инфицирования забрюшинного пространства у реципиента без первичного инфицирования ТПЖ на фоне адекватного хирургического лечения в сочетании с этиотропной антимикробной терапией и снижением иммуносупрессии возможно добиться излечения реципиента.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Surgical site infections (SSIs) following solid organ transplantation pose grave risks, including the potential loss of the transplanted organ and mortality of the recipient. The management of these infections is highly intricate and necessitates ongoing research and the refinement of treatment protocols to enhance outcomes.</p><p>The objective of this study is to illustrate a successful treatment approach for retroperitoneal infection in the surgical area following combined kidney and pancreas transplantation, with a particular focus on the region where the pancreas graft is located.</p></sec><sec><title>Material and methods</title><p>Material and methods. A 31-year-old female recipient of a kidney and pancreas transplant was diagnosed with type 1 diabetes mellitus, complicated by diabetic nephropathy, which had progressed to a terminal stage of chronic kidney disease. The clinical case was described using data from the recipient's medical history, observation card, and organ passport, along with the results of general clinical and instrumental investigations.</p></sec><sec><title>Results</title><p>Results. The clinical picture of the course of bacterial infection of the retroperitoneal space in the area of pancreas graft location and its successful treatment in a recipient after simultaneous pancreas and kidney transplantation is presented. Due to the choice of optimal treatment tactics, it was possible not only to avoid the development of sepsis, but also to preserve the function of both grafts.</p></sec><sec><title>Conclusion</title><p>Conclusion. The development of SSIs in the form of retroperitoneal infection in a recipient without primary infection of the pancreas graft, in the context of adequate surgical intervention, in conjunction with etiotropic antimicrobial therapy and a reduction in immunosuppression, is a condition that can be effectively treated, resulting in a positive outcome for the recipient.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекция области хирургического вмешательства</kwd><kwd>инфекционные осложнения</kwd><kwd>трансплантация почки и поджелудочной железы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>surgical site infection</kwd><kwd>infectious complications</kwd><kwd>kidney and pancreas transplantation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Deng Y, Li N, Wu Y, Wang M, Yang S, Zheng Y, et al. 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