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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transplantologiya</journal-id><journal-title-group><journal-title xml:lang="ru">Трансплантология</journal-title><trans-title-group xml:lang="en"><trans-title>Transplantologiya. The Russian Journal of Transplantation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-0506</issn><issn pub-type="epub">2542-0909</issn><publisher><publisher-name>IPO Association of Transplantologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23873/2074-0506-2025-17-4-452-460</article-id><article-id custom-type="elpub" pub-id-type="custom">transplantologiya-1060</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Применение метки аутолейкоцитов для поиска очага воспаления у пациента с пересаженной почкой</article-title><trans-title-group xml:lang="en"><trans-title>The use of autolоgous leucocyte labelling to search for the focus of inflammation in patient with a transplanted kidney</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7521-487X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мигунова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Migunova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мигунова Екатерина Валентиновна - д-р мед. наук, ведущий научный сотрудник отделения лучевой диагностики ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; профессор кафедры радиологии, радиотерапии, радиационной гигиены и радиационной безопасности имени академиков А.С. Павлова и Ф.Г. Кроткова ФГБОУ ДПО РМАНПО МЗ РФ.</p><p>129090, Москва, Большая Сухаревская пл., д. 3; 125993, Москва, Баррикадная ул., д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Ekaterina V. Migunova - Dr. Sci. (Med.), Leading Researcher, Diagnostic Radiology Department, N.V. Sklifosovsky Research Institute for Emergency Medicine; Professor of the Department of Radiology, Radiotherapy, Radiation Hygiene and Radiation Safety named after Academicians A.S. Pavlov and F.G. Krotkov, Russian Medical Academy of Continuous Professional Education.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090; 2/1 Bldg. 1 Barrikadnaya St., Moscow 125993</p></bio><email xlink:type="simple">migunovaev@sklif.mos.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1396-7048</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балкаров</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Balkarov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балкаров Аслан Галиевич - канд. мед. наук, заведующий научным отделением трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов им. В.П. Демихова МБФ ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет); заведующий организационно-методическим отделом по трансплантологии ГБУ «НИИОЗММ ДЗМ».</p><p>129090, Москва, Большая Сухаревская пл., д. 3; 117997, Москва, ул. Островитянова, д. 1; 115184, Москва, Большая Татарская ул., д. 30</p></bio><bio xml:lang="en"><p>Aslan G. Balkarov - Cand. Sci. (Med.), Head of the Scientific Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the V.P. Demikhov Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University); Head of the Organizational and Methodological Department for Transplantology, Research Institute for Healthcare Organization and Medical Management.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090; 1 Ostrovityanov St., Moscow 117997; 30 Bolshaya Tatarskaya St., Moscow 115184</p></bio><email xlink:type="simple">balkarovag@sklif.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8199-905X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмарина</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmarina</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шмарина Нонна Валерьевна - канд. мед. наук, старший научный сотрудник отделения трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов им. В.П. Демихова МБФ ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет).</p><p>129090, Москва, Большая Сухаревская пл., д. 3; 117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Nonna V. Shmarina - Cand. Sci. (Med.), Senior Researcher, Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the V.P. Demikhov Department of Transplantation and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University).</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090; 1 Ostrovityanov St., Moscow 117997</p></bio><email xlink:type="simple">shmarinanv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0473-9932</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>К. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>K. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазарева Ксения Евгеньевна - канд. мед. наук, врач эндокринолог, научный сотрудник отделения трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «РосУниМед» Минздрава России.</p><p>129090, Москва, Большая Сухаревская пл., д. 3; 127006, Москва, Долгоруковская ул., д. 4</p></bio><bio xml:lang="en"><p>Kseniya E. Lazareva - Cand. Sci. (Med.), Endocrinologist, Research Associate, Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090; 4 Dolgorukovskaya St., Moscow 127006</p></bio><email xlink:type="simple">lazarevake2@sklif.mos.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6811-6809</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никулина</surname><given-names>В. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikulina</surname><given-names>V. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никулина Валентина Петровна - канд. мед. наук, старший научный сотрудник лаборатории клинической иммунологии.</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Valentina P. Nikulina - Cand. Sci. (Med.), Senior Researcher, Clinical Immunology Laboratory, N.V. Sklifosovsky Research Institute for Emergency Medicine.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p></bio><email xlink:type="simple">nikulinavp@sklif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0924-8753</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рустамбек Уулу</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rustambek Uulu</surname><given-names>A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рустамбек Уулу Алишер - врач хирург отделения трансплантации почки и поджелудочной железы.</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Alisher Rustambek Uulu - Surgeon, Kidney and Pancreas Transplantation Department, N.V. Sklifosovsky Research Institute for Emergency Medicine.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p></bio><email xlink:type="simple">rustambekua@sllif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2232-7296</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лоньшаков</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lonshakov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лоньшаков Денис Владимирович - врач хирург отделения трансплантации почки и поджелудочной железы.</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Denis V. Lonshakov - Surgeon, Kidney and Pancreas Transplantation Department, N.V. Sklifosovsky Research Institute for Emergency Medicine.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p></bio><email xlink:type="simple">lonshakovdv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9669-9164</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамидова</surname><given-names>Л. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamidova</surname><given-names>L. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хамидова Лайлаъ Тимарбековна - д-р мед. наук, руководитель отдела лучевой диагностики.</p><p>129090, Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Layla T. Khamidova - Dr. Sci. (Med.), Head of the Radiology Department, N.V. Sklifosovsky Research Institute for Emergency Medicine.</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090</p></bio><email xlink:type="simple">khamidovalt@sklif.mos.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5731-3310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитриев Илья Викторович - д-р мед. наук, заведующий отделением трансплантации почки и поджелудочной железы ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; доцент кафедры трансплантологии и искусственных органов им. В.П. Демихова МБФ ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет).</p><p>129090, Москва, Большая Сухаревская пл., д. 3; 117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Ilya V. Dmitriyev - Dr. Sci. (Med.), Head of the Department of Kidney and Pancreas Transplantation, N.V. Sklifosovsky Research Institute for Emergency Medicine; Associate Professor of the V.P. Demikhov Department of Transplantation and Artificial Organs, N.I. Pirogov Russian National Research Medical University (Pirogov University).</p><p>3 Bolshaya Sukharevskaya Sq., Moscow 129090; 1 Ostrovityanov St., Moscow 117997</p></bio><email xlink:type="simple">dmitrieviv@sklif.mos.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГБОУ ДПО РМАНПО МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет); ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University (Pirogov University); Research Institute for Healthcare Organization and Medical Management</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ (Пироговский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University (Pirogov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ФГБОУ ВО «Российский университет медицины» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute for Emergency Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>11</day><month>12</month><year>2025</year></pub-date><volume>17</volume><issue>4</issue><fpage>452</fpage><lpage>460</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мигунова Е.В., Балкаров А.Г., Шмарина Н.В., Лазарева К.Е., Никулина В.П., Рустамбек Уулу А., Лоньшаков Д.В., Хамидова Л.Т., Дмитриев И.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Мигунова Е.В., Балкаров А.Г., Шмарина Н.В., Лазарева К.Е., Никулина В.П., Рустамбек Уулу А., Лоньшаков Д.В., Хамидова Л.Т., Дмитриев И.В.</copyright-holder><copyright-holder xml:lang="en">Migunova E.V., Balkarov A.G., Shmarina N.V., Lazareva K.E., Nikulina V.P., Rustambek Uulu A., Lonshakov D.V., Khamidova L.T., Dmitriev I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jtransplantologiya.ru/jour/article/view/1060">https://www.jtransplantologiya.ru/jour/article/view/1060</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Инфекционные осложнения у реципиентов почки способствуют значимому снижению показателей выживаемости трансплантатов и реципиентов. При трудностях определения источника и локализации воспаления у иммунокомпрометированных пациентов стандартными методами исследования возможно применение радионуклидного метода с использованием меченых аутолейкоцитов.</p></sec><sec><title>Цель</title><p>Цель. Исследование возможностей применения метки аутолейкоцитов у реципиента почки для поиска очага воспалительной инфильтрации.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Пациенту 33 лет выполнили первичную трансплантацию почки от посмертного донора. Ранний послеоперационный период осложнился развитием инфекционного процесса, локализацию которого не смогли выявить с помощью стандартных методов диагностики. Поиск воспалительного очага осуществляли с применением радионуклидной метки аутолейкоцитов.</p></sec><sec><title>Результаты</title><p>Результаты. Выполненное исследование позволило выявить очаг воспаления, который был представлен параколитическим инфильтратом в проекции нижней трети сигмовидной кишки вследствие еe микроперфорации. Очаг инфекции был санирован, что улучшило состояние пациента.</p></sec><sec><title>Выводы</title><p>Выводы. Применение уточняющих и не используемых в рутинной практике диагностических методов помогает своевременно и достаточно точно определять локализацию и размеры источника инфекции.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Infectious complications in kidney recipients contribute to a significant decrease in the survival rates of transplants and recipients. If it is difficult to determine the source and localization of inflammation in immunocompromised patients using standard research methods, it is possible to use a radionuclide method using labeled autoleukocytes.</p></sec><sec><title>Objective</title><p>Objective. To demonstrate the possibilities of using an autoleukocyte tag in a kidney recipient to search for a focus of inflammatory infiltration.</p></sec><sec><title>Material and methods</title><p>Material and methods. A 33-year-old patient underwent primary kidney transplantation from a postmortem donor. The early postoperative period was complicated by the development of an infection site, the localization of which could not be identified using standard diagnostic methods. The search for the inflammatory focus was carried out using the radionuclide label of autoleukocytes.</p></sec><sec><title>Results</title><p>Results. The study of radionuclide labelling of autologous leukocyte made it possible to identify the focus of inflammation, which was represented by infiltrate in the projection of the lower third of the sigmoid colon due to its microperforation. The treatment performed made it possible to cure this infectious complication.</p></sec><sec><title>Conclusions</title><p>Conclusions. The use of clarifying and non-routine diagnostic methods helps to promptly and accurately determine the location and size of the leukocyte infiltration.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация почки</kwd><kwd>инфекционные осложнения</kwd><kwd>очаг инфекции</kwd><kwd>диагностика инфекционных осложнений</kwd><kwd>метка аутолейкоцитов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>kidney transplantation</kwd><kwd>infectious complications</kwd><kwd>focus of infection</kwd><kwd>diagnosis of infectious complications</kwd><kwd>autologous leukocyte labeling</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Banach DB, Seville MTA, Kusne S. Infection prevention and control issues after solid organ transplantation. In: Ljungman P, Snydman D, Boeckh M. (eds.) Transplant infections. 4th ed. 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