transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologiststransplantologiya-121Research ArticleПРОБЛЕМНЫЕ АСПЕКТЫPROBLEMATIC ASPECTSЭффективность комбинации аллогенной богатой тромбоцитами плазмы с коллагеном при лечении дефектов бедренной кости у крысEffi ciency of allogenic platelet-rich plasmsa, combined with collagen, in rat's humerus injury healingВазаА. Ю.VazaA. Yu.vazal@inbox.ruМакаровМ. С.MakarovM. S.СластининВ. В.SlastininV. V.БоровковаН. В.BorovkovaN. V.КлюквинИ. Ю.KlyukvinI. Yu.ПохитоновД. Ю.PokhitonovD. Yu.ПономаревИ. Н.PonomarevI. N.ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ», МоскваРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, MoscowRussian Federation201606062016023644Copyright © Ваза А.Ю., Макаров М.С., Сластинин В.В., Боровкова Н.В., Клюквин И.Ю., Похитонов Д.Ю., Пономарев И.Н., 20162016Ваза А.Ю., Макаров М.С., Сластинин В.В., Боровкова Н.В., Клюквин И.Ю., Похитонов Д.Ю., Пономарев И.Н.Vaza A.Y., Makarov M.S., Slastinin V.V., Borovkova N.V., Klyukvin I.Y., Pokhitonov D.Y., Ponomarev I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/121

Проведен эксперимент по исследованию действия богатой тромбоцитами плазмы (БоТП) в сочетании с коллагеном на процесс регенерации кости в дистальном отделе бедра крыс. Используемая доза крысиной БоТП содержала 130–135 пг/мл тромбоцитарного фактора роста (PDGF). Установлено, что при таком уровне PDGF комбинация БоТП и коллагена значительно ускоряла рост костных трабекул в области дефекта, стимулировала ангиогенез и снижала интенсивность воспалительной реакции. У всех обследованных животных использование аллогенной БоТП позволило в 2 раза сократить сроки репарации дефекта бедренной кости.

In experiment we studied influence of collagen, filled with platelet-rich plasma (PRP), on rats' bone regeneration in distal humerus. Used dose of PRP contained 130–135 pg/ml platelet-derived growth factor (PDGF). According to this level of PDGF, PRP-collagen treatment rapidly enhanced trabecular bones' growth, stimu-lated angiogenesis and reduced intensity of inflammation. Allogenic PRP, addressed to all experimental animals, allowed to make humerus healing 2 times shorter.

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The authors declare that there are no conflicts of interest present.