References

transplantologiya

Трансплантология

Transplantologiya. The Russian Journal of Transplantation

2074-05062542-0909

IPO Association of Transplantologists

transplantologiya-142

Research Article

ОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИ

REVIEW ARTICLES AND LECTURES

Трансплантация органов от доноров, зараженных гемоконтактными вирусными инфекциями. Опыт зарубежных стран

Transplantation of organs from donors infected with blood-borne viral infections. The experience of foreign countries

Хубутия

М. Ш.

Khubutiya

M. Sh.

sklifos@inbox.ru

Солонин

С. А.

Solonin

S. A.

sklifos@inbox.ru

Годков

М. А.

Godkov

M. A.

sklifos@inbox.ru

ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentRussian Federation

2016

13122016

044857

2016

Хубутия М.Ш., Солонин С.А., Годков М.А.

Khubutiya M.S., Solonin S.A., Godkov M.A.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.jtransplantologiya.ru/jour/article/view/142

Проанализирован зарубежный опыт трансплантаций органов от доноров, зараженных гемоконтактными вирусными инфекциями (ГВИ). Снятие запрета на трансплантацию таких органов способствует расширению донорского пула и сокращает время нахождения больных в Листах ожидания. Вместе с тем использование донорских органов с маркерами ГВИ зачастую связано с повышенным риском осложнений и смертельныхисходов среди реципиентов.

We have analyzed the foreign experience of organ transplantation from donors infected with blood-borne viruses (BBVIs). Lifting of the ban on the transplantation of organs positive for BBVI markers contributes to the expansion of the donor pool and reduces time spent on Waiting lists. At the same time, the use of donor organs positive for BBVI markers is often associated with an increased risk of complications and deaths among recipients.

ВИЧгепатит Вгепатит Странсплантация печенитрансплантация почекгемоконтактные вирусные инфекции

HIVHBVHCVliver transplantationkidney transplantationblood-borne viral infections

References1

Organ donation and transplantation activities, 2013 [Electronic resource]. – URL: http://www.transplant-observatory.org/Documents/Data%20Reports/Basic%20slides%202013_corregido.pdf

Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2012 Annual Data Report. Rockville, MD: Department of Health and Human Services, Health Resources and Services Administration; 2014 [Electronic resource]. – URL: http://srtr.transplant.hrsa.gov/annual_reports/2012/pdf/2012_SRTR_ADR_updated_full_intro.pdf

Ando, M. Epidemiology, clinical characteristics, and management of chronic kidney disease in human immunodeficiency virus-infected patients / M. Ando, N. Yanagisawa // World J. Nephrol. – 2015. – Vol. 4, N.3. – P. 388–395. PMID: 26167463

WHO media centre. HIV/AIDS. [Electronic resource].- URL: http://www.who.int/mediacentre/factsheets/fs360/ru/

WHO media centre. Hepatitis B. [Electronic resource].- URL: http://www.who.int/mediacentre/factsheets/fs204/ru/

WHO media centre. Hepatitis C. [Electronic resource].- URL: http://www.who.int/mediacentre/factsheets/fs164/ru/

Annual Report 2014. Eurotransplant International Foundation. [Electronic resource]. – URL: http://www.eurotransplant.org/cms/mediaobject.php?file=ar_2014.pdf

Halldorson, J. Decadal analysis of deceased organ donation in Spain and the United States linking an increased donation rate and the utilization of older donors / J. Halldorson, J.P. Roberts // Liver Transpl. – 2013. – Vol. 19, N. 9. – P. 981–986. PMID: 23780795.

Liver transplantation using elderly donors: a risk factor analysis / D.Y. Kim, J. Moon, E.R. Island [et al.] // Clin. Transplant. – 2011. – Vol. 25, N. 2. – P. 270– 276. PMID: 20184629.

Patient and graft outcomes from deceased kidney donors age 70 years and older: an analysis of the Organ Procurement Transplant Network/United Network of Organ Sharing database /D. Chavalitdhamrong, J. Gill, S. Takemoto [et al.] // Transplantation – 2008. – Vol. 85, N. 11. – P. 1573–1579. PMID: 18551062.

Ramos, E. Expanding the donor pool: effect on graft outcome / E. Ramos, S. Aoun, W.E. Harmon // J. Am. Soc. Nephrol. – 2002. – Vol. 13, N. 10. – P. 2590–2599. PMID: 12239250.

Fishman, J.A. Infection in solid-organ transplant recipients / J.A. Fishman //N. Engl. J. Med. – 2007. – Vol.357, N. 25. – P. 2601–2614. PMID: 18094380.

Prevalence of chronic hepatitis B among foreign-born persons living in the United States by country of origin / K.V. Kowdley, C.C. Wang, S. Welch [et al.] // Hepatology. – 2012. – Vol. 56, N. 2. – P. 422–433. PMID: 22105832.

Prevalence of chronic hepatitis B virus (HBV) infection in US households – National Health and Nutrition Examination Survey (NHANES), 1988-2012 /H. Roberts, D. Kruszon-Moran, K.N. Ly [et al.] // Hepatology. – 2016. – Vol. 63, N. 2. – P. 388–397. PMID: 26251317.

Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010 / M.M. Denniston, R.B. Jiles, J. Drobeniuc [et al.] // Ann. Intern. Med. – 2014. – Vol.160, N. 5. – P. 293–300. PMID: 24737271.

Prevalence of Diagnosed and Undiagnosed HIV Infection – United States, 2008-2012 / Hall H.I., An Q., Tang T. [et al.] // MMWR. Morb. Mortal. Wkly Rep. – 2015. – Vol. 64, N. 24. – P. 657–662.

European Centre for Disease Prevention and Control. Annual epidemiological report 2014 – sexually transmitted infections, including HIV and blood-borne viruses. – Stockholm: ECDC, 2015.

Katchaki, J.N. Serological evidence of presence of HBsAg undetectable by conventional radioimmunoassay in anti-HBc positive blood donors /J.N. Katchaki, T.H. Siem, R. Brouwer // J. Clin. Pathol. – 1978. – Vol. 31, N.9. – P. 837– 839. PMID: 711912.

Raimondo, G. Statements from the Taormina expert meeting on occult he patitis B virus infection / G. Raimondo, J.P. Allain, M.R. Brunetto // J. Hepatol. – 2008. – Vol. 49, N. 4. – P. 652–657. PMID: 18715666.

Characteristics associated with liver graft failure: the concept of a donor risk index / S. Feng, N. Goodrich, J. Bragg-Gresham [et al.] // Am. J. Transplant. – 2006.– Vol.6, N. 4. – P. 783–790. PMID: 16539636.

Hepatitis B-core antibody positive donors in liver transplantation and their impact on graft survival: evidence from the Liver Match cohort study /M. Angelico, A. Nardi, T. Marianelli [et al.] // J. Hepatol. – 2013. – Vol.58, N. 4. – P. 715–723. PMID: 23201239.

Risk for de novo hepatitis B from antibody to hepatitis B core antigenpositive donors in liver transplantation in Singapore / K.H. Lee, C.T. Wai, S.G. Lim [et al.] // Liver Transpl. – 2001. – Vol. 7, N. 5. – P. 469–470. PMID: 11349271

Skagen, C.L. Risk of de novo hepatitis in liver recipients from hepatitis-B core antibody-positive grafts – a systematic analysis / C.L. Skagen, J.H. Jou, A. Said // Clin. Transplant. – 2011. – Vol. 25, N. 3. – E. 243–249. PMID: 21323735.

Horan, J.L. Hepatitis B core antibody-positive donors in cardiac transplantation: a single-center experience / J.L. Horan, J.E. Stout, B.D. Alexander // Transpl. Infect. Dis. – 2014. – Vol. 16, N. 5. – P. 859–863. PMID: 25154437.

Hepatitis B core antibody positive donors as a safe and effective therapeutic option to increase available organs for lung transplantation / M.G. Hartwig, V. Patel, S.M. Palmer [et al.] // Transplantation – 2005. – Vol. 80, N. 3. – P. 320–325. PMID: 16082326.

Kidney transplantation from hepatitis B virus core antibody-positive donors: prophylaxis with hepatitis B immunoglobulin / M. Veroux, D. Corona, B. Ekser // Transplant Proc. – 2011. – Vol. 43, N. 4. – P. 967–970. PMID: 21620027.

Liver transplantation in hepatitis B core-negative recipients using livers from hepatitis B core-positive donors: a 13-year experience / H.E. Bohorquez, A.J. Cohen, N. Girgrah // Liver Transpl. – 2013. – Vol. 19, N. 6. – P. 611– 618. PMID: 23526668.

Evolving experience of hepatitis B virus prophylaxis in liver transplantation / M.R. Honaker, M.H. Shokouh- Amiri, S.R. Vera // Transpl. Infect. Dis. – 2002. – Vol. 4, N. 3. – P. 137–143. PMID: 12421458.

The Effect of Hepatitis B Virus on Graft and Overall Survival in Kidney Transplant Patients / Ö. Harmanc

Cholongitas, E. Liver grafts from anti-hepatitis B core positive donors: a systematic review / E. Cholongitas, G.V. Papatheodoridis, A.K. Burroughs // J. Hepatol. – 2010. – Vol. 52, N. 2. – P. 272–279. PMID: 20034693.

Liver transplantation for HBsAg-positive recipients using grafts from HBsAgpositive deceased donors / Y. Choi, J.Y. Choi, N.J. Yi // Transpl. Int. – 2013. – Vol. 26, N. 12. – P. 1173–1183. PMID: 24131436.

Transplantation of hepatitis B surface antigen-positive livers into hepatitis B virus-positive recipients and the role of hepatitis delta coinfection / Franchello A., Ghisetti V., Marzano A. [et al.] // Liver Transplant. – 2005. – Vol. 11, N. 8. – P. 922–928. PMID: 16035057.

Liver transplantation from hepatitis B surface antigen positive donors: a safe way to expand the donor pool / E. Loggi, L. Micco, G. Ercolani [et al.] // J. Hepatol. – 2012. – Vol. 56, N. 3. – P. 579–585. PMID: 22027583.

Course of a HBsAg positive liver transplantation in a hepatitis B and D virus coinfected recipient / R. Bahde, J.P. Hölzen, H.H. Wolters [et al.] // Ann. Hepatol. – 2011. – Vol. 10, N. 3. – P. 355– 360. PMID: 21677340.

Prevention of hepatitis B recurrence after liver transplantation using lamivudine or lamivudine combined with hepatitis B Immunoglobulin prophylaxis / S. Zheng, Y. Chen, T. Liang // Liver Transpl. – 2006. – Vol. 12, N. 2. – P. 253– 258. PMID: 16447195.

Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B / S. Mirandola, D. Campagnolo, G. Bortoletto [et al.] // J. Viral. Hepat. – 2011. – Vol. 18, N. 7. – e212–216. PMID: 21692935.

Pattullo, V. Hepatitis B reactivation in the setting of chemotherapy and mmunosuppression – prevention is better than cure / V. Pattullo // World J. Hepatol. – 2015. – Vol. 7, N. 7, – P. 954–967. PMID: 25954478.

Levitsky, J. Viral hepatitis in solid organ transplantation / J. Levitsky, K. Doucette // Am. J. Transplant. – 2013. – Vol. 13, Suppl. 4. – P. 147–168. PMID: 23465008.

Solid organ transplantation from hepatitis B virus-positive donors: consensus guidelines for recipient management / S. Huprikar, L. Danziger-Isakov, J. Ahn [et al.] // Am. J. Transplant. – 2015. – Vol. 15, N. 5. – P. 1162–1172. PMID: 25707744.

Estimated risk of human immunodeficiency virus and hepatitis C virus infection among potential organ donors from 17 organ procurement organizations in the United States / K. Ellingson, D. Seem, M. Nowicki [et al.] // Am. J. Transplant. – 2011. – Vol. 11, N. 6. – P. 1201–1208. PMID: 21645253.

Grassi, A. Post-liver transplant hepatitis C virus recurrence: an unresolved thorny problem / A. Grassi, G. Ballardini // World J. Gastroenterol. – 2014. – Vol. 20, N. 32. – P. 11095–11115. PMID: 25170198

Liver allografts from hepatitis C positive donors can offer good outcomes in hepatitis C positive recipients: a US National Transplant Registry analysis /P.G. Northup, C.K. Argo, D.T. Nguyen [et al.] // Transpl. Int. – 2010. – Vol. 23, N. 10. – P. 1038–1044. PMID: 20444239.

Survival after liver transplantation using hepatitis C virus-positive donor allografts: case-controlled analysis of the UNOS database / A.T. Burr, Y. Li, J.F. Tseng [et al.] // World J. Surg. – 2011. – Vol. 35, N. 7. – P. 1590–1595. PMID: 21384242.

Kucirka, L.M. Impact of donor he patitis C virus infection status on death and need for liver transplant in hepatitis C virus-positive kidney transplant recipients / L.M. Kucirka, T.G. Peters, D.L. Segev // Am. J. Kidney Dis. – 2012. – Vol. 60, N. 1. - P. 112–120. PMID: 22560841.

HCV-related fibrosis progression following liver transplantation: increase in recent years / M. Berenguer, L. Ferrell, J. Watson [et al.] // J. Hepatol. – 2000. – Vol. 32, N. 4. – P. 673–684. PMID:10782918.

Risk of advanced fibrosis with grafts from hepatitis C antibody-positive donors: a multicenter cohort study / J.C. Lai, J.G. O'Leary, J.F. Trotter // Liver Transpl. – 2012. – Vol. 18, N. 5. – P. 532–538. PMID: 22271671.

Impact of donor and recipient hepatitis C status in lung transplantation / B.R. Englum, A.M. Ganapathi, P.J. Speicher [et al.] // J. Heart Lung Transplant. – 2016. – Vol. 35, N. 2. – P. 228–235. PMID: 26615769.

Montenovo, M.I. Donor hepatitis C sero-status does not impact survival in liver transplantation / M.I. Montenovo, A.A. Dick, R.N. Hansen // Ann. Transplant. – 2015. – Vol. 20. – P. 44–50. PMID: 25608491.

Coilly, A. Pros and Cons: Usage of organs from donors infected with hepatitis C virus – Revision in the direct-acting antiviral era / A. Coilly, D. Samuel // J. Hepatol. – 2016. – Vol. 64, N. 1. – P. 226– 231. PMID: 26375245.

Effects of ethnicity and socioeconomic status on survival and severity of fibrosis in liver transplant recipients with hepatitis C virus / E.C. Verna, R. Valadao, E. Farrand [et al.] // Liver Transpl. – 2012. – Vol. 18, N. 4. – P. 461–467. PMID: 22467547.

Gane, E.J. Directly acting antivirals (DAAs) for the treatment of chronic hepatitis C virus infection in liver transplant patients: “a flood of opportunity” / E.J. Gane, D. Agarwal // Am. J. Transplant. – 2014. – Vol. 14, N. 5. – P. 994– 1002. PMID: 24730431.

An interferon-free antiviral regimen for HCV after liver transplantation / P.Y. Kwo, P.S. Mantry, E. Coakley [et al.] // N. Engl. J. Med. – 2014. – Vol. 371, N. 25. – P. 2375–2382. PMID: 25386767.

Hepatitis C genotype influences postliver transplant outcomes / I. Campos- Varela, J.C. Lai, E.C. Verna [et al.] // Transplantation. – 2015. – Vol. 99, N. 4. – P. 835–840. PMID: 25211520.

Costs oftelaprevir-based triple therapy for hepatitis C: $189,000 per ustainedvirological responses / K. Bichoupan, V. Martel-Laferriere, D. Sachs [et al.] // Hepatology – 2014. – Vol. 60, N. 4. – P. 1187–1195. PMID: 25065814.

Health Resources and Services Administration (HRSA), Department of Health and Human Services (HHS). Organ procurement and transplantation: implementation of the HIV Organ Policy Equity Act. Final rule. // Fed. Regist. – 2015. – Vol. 80, N. 89. – P. 26464–26467. PMID: 25985481.

HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes / M.E. Roland, B. Barin, L. Carlson [et al.] // Am. J. Transplant. – 2008. – Vol. 8, N. 2. – P. 355–365. Erratum in: Am J Transplant. – 2008. – Vol. 8, N. 5. – P. 1081. PMID: 18093266.

HIV-positive-to-HIV-positive kidney transplantation – results at 3 to 5 years / E. Muller, Z. Barday, M. Mendelson, D. Kahn // N. Engl. J. Med. – 2015. – Vol. 372, N. 7. – P. 613–620. PMID: 25671253.

Outcomes of kidney transplantation in HIV-infected recipients / P.G. Stock, B. Barin, B. Murphy [et al.] // N. Engl. J. Med. – 2010. – Vol. 363, N. 21. – P. 2004–2014. Erratum in: N. Engl. J. Med. – 2011. – Vol. 364, N. 11. – P. 1082. PMID: 21083386.

Estimating the potential pool of HIV-infected deceased organ donors in the United States / B.J. Boyarsky, E.C. Hall, A.L. Singer [et al.] // Am. J. Transplant. – 2011. – Vol. 11, N. 6. – P. 1209– 1217. PMID: 21443677.

PHS Guideline for Reducing Human Immunodeficiency Virus, Hepatitis B Virus, and Hepatitis C Virus Transmission Through Organ Transplantation. [Electronic resource]. – URL: http:// www.publichealthreports.org/issueopen.cfm?articleID=2975

The authors declare that there are no conflicts of interest present.