transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologiststransplantologiya-143Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESХарактеристика иммунных нарушений у пациентов при терминальной стадии хронической почечной недостаточностиImmune dysfunction in patients with end-stage chronic renal failureДостиевУ. А.DostievU. A.umed.dostiev@yandex.comДостиевА. Р.DostievA. R.face@neicon.ruКаримовА. М.KarimovA. M.face@neicon.ruГУ «Таджикский государственный медицинский университет им. Абуали ибни Сино»ТаджикистанTajik State Medical University named after Abu Ali Ibn SinoTajikistan201613122016045862Copyright © Достиев У.А., Достиев А.Р., Каримов А.М., 20162016Достиев У.А., Достиев А.Р., Каримов А.М.Dostiev U.A., Dostiev A.R., Karimov A.M.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/143

В данном обзоре представлен анализ источников литературы по расстройству иммунной системы при терминальной стадии хронической почечной недостаточности (ТХПН), в котором подчеркнута особая роль уремии и связанных с ней изменений. Наконец, на основе новых связей между изменениями в иммунной системе при ТХПН у пациентов обращено внимание на потенциальную значимость иммунной дисфункции как основнойпричины высокой смертности в этой популяции больных и необходимость более тщательных исследований в этой области.

This literature review presents an immune system disorder in end-stage renal disease (ESRD), emphasizing the specific role of uremia and related changes. Finally, on the basis of new relationships between the changes in the immune system of ESRD patients, it emphasizes the potential role of the immune dysfunction as the main cause of the highmortality in this patient population and the need for further research in this area.

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The authors declare that there are no conflicts of interest present.