transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2017-9-4-335-349transplantologiya-201Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESПричины развития и методы коррекции посттрансплантационного сахарного диабетаThe causes of development and methods of correction of post-transplant diabetes mellitusЛазареваК. Е.LasarevaK. E.

канд. мед. наук, врач-эндокринолог отделения трансплантации почки и поджелудочной железы НИИ скорой помощи им. Н.В. Склифосовского

Москва

Cand. Med. Sci., Endocrinologist of the Kidney and Pancreas Transplantation Department at N.V. Sklifosovsky Research Institute for Emergency Medicine

Moscow

suksenia@yandex.ruРжевскаяО. Н.RzhevskayaO. N.

Москва

Moscow

ЗагородниковаН. В.ZagorodnikovaN. V.

Москва

Moscow

ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФГБОУ ВО МГМСУ им. А.И. Евдокимова МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; Department of Transplantology and Artificial Organs of the Moscow State University of Medicine and Dentistry n.a. A.I. EvdokimovRussian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation20171812201794335349Copyright © Лазарева К.Е., Ржевская О.Н., Загородникова Н.В., 20172017Лазарева К.Е., Ржевская О.Н., Загородникова Н.В.Lasareva K.E., Rzhevskaya O.N., Zagorodnikova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/201

Обзор посвящен проблеме посттрансплантационного сахарного диабета как одного из осложнений после трансплантации почки. Проведен анализ клинических и экспериментальных исследований, описаны механизмы влияния иммуносупрессивных препаратов на углеводный обмен, а также факторы риска посттрансплантационного сахарного диабета и его осложнений, основные препараты, применяемые для коррекции углеводного обмена, и их механизмы действия.

The Review deals with the problem of post-transplant diabetes mellitus as one of the complications after kidney transplantation. The authors have reviewed the clinical and experimental studies, described the mechanisms of immunosuppressive drug effects on carbohydrate metabolism and the risk factors for posttransplant diabetes mellitus and its complications, discussed the main drugs used for the carbohydrate metabolism correction and their mechanisms of action.

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The authors declare that there are no conflicts of interest present.