transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologiststransplantologiya-27Research ArticleПРОБЛЕМНЫЕ АСПЕКТЫPROBLEMATIC ASPECTSОпыт применения адваграфа после трансплантации почки в НИИ СП им. Н.В. СклифосовскогоExperience of using advagraf after kidney transplantation in the Sklifosofsky Research Institute for Emergency MedicineПинчукА. В.PinchukA. V.ШмаринаН. В.ShmarinB. V.nonna_shm@mail.ruСторожевР. В.StorojevR. V.БалкаровА. Г.BalkarovA. G.ДмитриевИ. В.DmitrievI. V.БалакиревЭ. М.BalakirevE. M.ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗ г. Москвы»РоссияSklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare DepartmentRussian Federation20132801201604Трансплантология1014Copyright © Пинчук А.В., Шмарина Н.В., Сторожев Р.В., Балкаров А.Г., Дмитриев И.В., Балакирев Э.М., 20162016Пинчук А.В., Шмарина Н.В., Сторожев Р.В., Балкаров А.Г., Дмитриев И.В., Балакирев Э.М.Pinchuk A.V., Shmarin B.V., Storojev R.V., Balkarov A.G., Dmitriev I.V., Balakirev E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/27

Оценена эффективность адваграфа в качестве основного иммуносупрессанта у реципиентов почечного трансплантата в раннем послеоперационном периоде. Подтверждена хорошая переносимость препарата. Отмечены удовлетворительные показатели восстановления функции почечного трансплантата после операции. Даны рекомендации по применению адваграфа в ранние сроки после трансплантации почки, в том числе при нарушении функции желудочно-кишечного тракта.

 

The efficiency of the advagraf as the main immunosuppressant in renal transplant recipients in the early postoperative period has been assessed. A good tolerability of the medicament has been confirmed. Satisfactory performance of renal graft function recovery after surgery was marked. Recommendations on the use of the advagraf in the early terms after kidney transplantation, including a condition of a violation of the gastrointestinal tract function.

трансплантация почкииммуносупрессияадваграфkidney transplantationimmunosuppressionadvagrafReferencesTacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients; meta-analysis and meta-regression of randomized trail data / A.C. Webster, R.C. Woodroffe, R.S. Taylor [et al.] // Br. Med. J. – 2005. – Vol. 331. – P. 810–820.Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients; meta-analysis and meta-regression of randomized trail data / A.C. Webster, R.C. Woodroffe, R.S. Taylor [et al.] // Br. Med. J. – 2005. – Vol. 331. – P. 810–820.Иммуносупрессия при трансплантации солидных органов / под ред. С. В. Готье. – М.: Триада, 2011. – С. 30–35.Иммуносупрессия при трансплантации солидных органов / под ред. С. В. Готье. – М.: Триада, 2011. – С. 30–35.Kramer, B.K. Better tolerability and significantly higher freedom from acute rejection at 7 years with tacrolimus vs cyclosporin-based immunosupression in renal transplant recipients / B.K Kramer // XLVII ERA-EDTA Congress-II DgfN Congress Munich, Germany, 2010, June25–28. – Munich, 2010. – Abst. OSu020.Kramer, B.K. Better tolerability and significantly higher freedom from acute rejection at 7 years with tacrolimus vs cyclosporin-based immunosupression in renal transplant recipients / B.K Kramer // XLVII ERA-EDTA Congress-II DgfN Congress Munich, Germany, 2010, June25–28. – Munich, 2010. – Abst. OSu020.Barratt, J. Immunosuppression for renal transplantation / J. Barratt, K. Harris, P. Topham // Oxford Desk Reference Nephrology / eds. J. Barratt, K. Harris, P. Topham. – Oxford: University press, 2009. – P. 563–564.Barratt, J. Immunosuppression for renal transplantation / J. Barratt, K. Harris, P. Topham // Oxford Desk Reference Nephrology / eds. J. Barratt, K. Harris, P. Topham. – Oxford: University press, 2009. – P. 563–564.Хубутия, М.Ш. Трансплантация почки / М.Ш. Хубутия, А.В. Пинчук // Трансплантация органов и тканей в многопрофильном научном центре / под ред. М.Ш. Хубутия. – М.: АирАтр, 2011. – Гл.6. – С. 158–161.Хубутия, М.Ш. Трансплантация почки / М.Ш. Хубутия, А.В. Пинчук // Трансплантация органов и тканей в многопрофильном научном центре / под ред. М.Ш. Хубутия. – М.: АирАтр, 2011. – Гл.6. – С. 158–161.Prograf and Advagraf Mix-up [Электронный ресурс] // ISMP Canada Safety Bulletin. – 2009. – Vol. 9, N 5. – Режим доступа: http://www.ismp-canada.org/download/safetyBulletins/ISMPCSB20095-PrografandAdvagrafMix-up.pdfPrograf and Advagraf Mix-up [Электронный ресурс] // ISMP Canada Safety Bulletin. – 2009. – Vol. 9, N 5. – Режим доступа: http://www.ismp-canada.org/download/safetyBulletins/ISMPCSB20095-PrografandAdvagrafMix-up.pdfImproved adherence to tacrolimus oncedaily formulation in renal recipients: a randomized controlled trial using electronic monitoring / D.R.J. Kuypers, P.C. Peeters, J.J. Sennesael [et al.] // Transplantanion. – 2013. – Vol.95, N.2. – P. 333–340.Improved adherence to tacrolimus oncedaily formulation in renal recipients: a randomized controlled trial using electronic monitoring / D.R.J. Kuypers, P.C. Peeters, J.J. Sennesael [et al.] // Transplantanion. – 2013. – Vol.95, N.2. – P. 333–340.Conversion from prograf to extendedrelease tacrolimus in stable kidney transplant recipients: Better renal function after 3 year follow up / G. Spagnoletti, A. Gargiulo, E. Favi [et al.] // 16th Congress of the European Society for Organ Transplantation and using the Ecosystem.Vienna, 2013, 8–11 September. – Vienna, 2013. – Abst. ВО158.Conversion from prograf to extendedrelease tacrolimus in stable kidney transplant recipients: Better renal function after 3 year follow up / G. Spagnoletti, A. Gargiulo, E. Favi [et al.] // 16th Congress of the European Society for Organ Transplantation and using the Ecosystem.Vienna, 2013, 8–11 September. – Vienna, 2013. – Abst. ВО158.Four-year experience with tacrolimus once-daily prolonged relase in patients from phase II conversion and de novo kidney, liver and heart studies / J.P. van Hooff, R.R. Alloway, P. Trunečka, M. Mourad // Clin. Transplant. – 2011. – Vol. 25, N. 1. – P.E 1–12.Four-year experience with tacrolimus once-daily prolonged relase in patients from phase II conversion and de novo kidney, liver and heart studies / J.P. van Hooff, R.R. Alloway, P. Trunečka, M. Mourad // Clin. Transplant. – 2011. – Vol. 25, N. 1. – P.E 1–12.Effect of conversion from twice-daily to once-daily tacrolimus on glucose intolerance in stabil kidney transplant recipient – evaluation at 12 months / I. Shinichi, T. Tomohiro, N. Shingo [et al.] // 16th Congress of the European Society for Organ Transplantation and using the Ecosystem. Vienna, 2013, 8–11 September. – Vienna, 2013. – Abst. ВО189.Effect of conversion from twice-daily to once-daily tacrolimus on glucose intolerance in stabil kidney transplant recipient – evaluation at 12 months / I. Shinichi, T. Tomohiro, N. Shingo [et al.] // 16th Congress of the European Society for Organ Transplantation and using the Ecosystem. Vienna, 2013, 8–11 September. – Vienna, 2013. – Abst. ВО189.

The authors declare that there are no conflicts of interest present.