transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2010-0-1-54-57transplantologiya-270Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSАнемия у реципиентов аллотрансплантированных почекAnemia in renal allograft recipientsГоряйновВ. А.GoryainovV. A.

Отделение трансплантации почки

Виктор Андреевич Горяйнов 

Department of Renal Transplantation

vik-kid@mail.ruКаабакМ. М.KaabakM. M.

Отделение трансплантации почки

Department of Renal Transplantation

ШишлоЛ. А.ShishloL. A.

Отделение трансплантации почки

Department of Renal Transplantation

БабенкоН. Н.BabenkoN. N.

Отделение трансплантации почки

Department of Renal Transplantation

МорозоваМ. М.MorozovM. M.

Отделение трансплантации почки

Department of Renal Transplantation

РНЦХ им. акад. Б.В. Петровского РАМНРоссияAcad. B.V. Petrovsky Russian Surgery Research Center, Russian Academy of Medical SciencesRussian Federation201017082018015457Copyright © Горяйнов В.А., Каабак М.М., Шишло Л.А., Бабенко Н.Н., Морозова М.М., 20182018Горяйнов В.А., Каабак М.М., Шишло Л.А., Бабенко Н.Н., Морозова М.М.Goryainov V.A., Kaabak M.M., Shishlo L.A., Babenko N.N., Morozov M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/270

Обзор посвящен одному из осложнений посттрансплантационного периода – анемии. В целях определения путей профилактики данного осложнения в посттрансплантационном периоде проанализированы факторы, способствующие его развитию. Показано, что анемия отрицательно влияет на функцию аллотрансплантированной почки и актуарную выживаемость реципиентов аллопочек. Отражены современные принципы лечения посттрансплантационной анемии.

The review deals with anemia, one of the posttransplantation complications. To define the ways of preventing this complication in the posttransplantation period, the factors favors its development are analyzed. Anemia is shown to negatively affect autografted kidney function and actuarial survival in allokidney graft recipients. The current principles in the treatment of posttransplantation anemia are reflected.

трансплантация почкипосттрансплантационная анемияэритропоэтиниммунодепрессиямиелотоксичностьrenal transplantationposttransplantation anemiaerythropoietinimmunosuppressionmyelotoxicityReferencesVanrenterghem Y., Ponticelly C., Morales J.M. et al. Prevalence and management of anemia in renal transplants recipients: a European survey. Am J Transplant 2003;3:835–45.Vanrenterghem Y., Ponticelly C., Morales J.M. et al. Prevalence and management of anemia in renal transplants recipients: a European survey. Am J Transplant 2003;3:835–45.Augustine J.J., Hricik D.E. Anemia after kidney transplantation: time for action. J Am Soc Nephrol 2006;17:2962–3.Augustine J.J., Hricik D.E. Anemia after kidney transplantation: time for action. J Am Soc Nephrol 2006;17:2962–3.Bagga A., Hari P., Moudgil A. et al. Mycophenolate mofetil and prednisolone therapy in children with steroid-dependent nephritic syndrome. Am J Kidney Dis 2003;42:1114–20.Bagga A., Hari P., Moudgil A. et al. Mycophenolate mofetil and prednisolone therapy in children with steroid-dependent nephritic syndrome. Am J Kidney Dis 2003;42:1114–20.Filler G., Gripas R., Mai I et al. Pharmacokinetics of tacrolimus (FK506) in children and adolescents with renal transplants. Nephrol Dial Transplant 1997;12:1668–71.Filler G., Gripas R., Mai I et al. Pharmacokinetics of tacrolimus (FK506) in children and adolescents with renal transplants. Nephrol Dial Transplant 1997;12:1668–71.Gouva C., Nikolopoulos P., Ioanidis J.P. et al. Treating anemia early in renal failure patients slows the decline of renal function; a randomized controlled trial. Kidney Dis 2004;66:753–60.Gouva C., Nikolopoulos P., Ioanidis J.P. et al. Treating anemia early in renal failure patients slows the decline of renal function; a randomized controlled trial. Kidney Dis 2004;66:753–60.Kolonko A., Pinoci-Mandok J., Kocierz M. et al. Anemia and erythrocytosis after kidney transplantation: 5-year graft function and survival analysis. Transplant Proc 2009;41(8):3046–51.Kolonko A., Pinoci-Mandok J., Kocierz M. et al. Anemia and erythrocytosis after kidney transplantation: 5-year graft function and survival analysis. Transplant Proc 2009;41(8):3046–51.Mahmud S.N., Aziz R., Akhtar F. et al. Anemia characteristics after renal transplantation. Transplant Proc 2002;34:24–8.Mahmud S.N., Aziz R., Akhtar F. et al. Anemia characteristics after renal transplantation. Transplant Proc 2002;34:24–8.Moore J., Cockwell P., Little M.A. et al. The impact of hemoglobin levels on patient and graft survival in renal transplant recipients. Transplantation 2008;86(4):564–70.Moore J., Cockwell P., Little M.A. et al. The impact of hemoglobin levels on patient and graft survival in renal transplant recipients. Transplantation 2008;86(4):564–70.Mitsnefes M.M., Subat-Dezulovic M., Khoury P.R. et al. Increasing incidence of post-kidney transplant anemia in children. Am J Transplant 2005;5:1713–8.Mitsnefes M.M., Subat-Dezulovic M., Khoury P.R. et al. Increasing incidence of post-kidney transplant anemia in children. Am J Transplant 2005;5:1713–8.Ponticelli C., Villa M. Role of anemia in cardiovascular mortality and morbidity in transplant patients. Nephrol Dial Transplant 2002;17(Suppl 1):41–6.Ponticelli C., Villa M. Role of anemia in cardiovascular mortality and morbidity in transplant patients. Nephrol Dial Transplant 2002;17(Suppl 1):41–6.Rossert J., Fouqueray B., Boffa J.J. Anemia management and the delay of chronic renal failure progression. J Am Soc Nephrol 2003;14:173–7.Rossert J., Fouqueray B., Boffa J.J. Anemia management and the delay of chronic renal failure progression. J Am Soc Nephrol 2003;14:173–7.Turkowski-Duhem A., Kamar N., Cointault O. et al. Predictive factors of anemia within the first year post renal transplant. Transplantation 2005;7:903–9.Turkowski-Duhem A., Kamar N., Cointault O. et al. Predictive factors of anemia within the first year post renal transplant. Transplantation 2005;7:903–9.Van Biesen W., Vanholder R., Neys N. et al. Efficacy of erythropoietin administration in the treatment of anemia immediately after renal transplantation. Transplantation 2005;79(3):367–8.Van Biesen W., Vanholder R., Neys N. et al. Efficacy of erythropoietin administration in the treatment of anemia immediately after renal transplantation. Transplantation 2005;79(3):367–8.Winkelmayer W.C., Kewalramani R., Rutstein M. et al. Pharmacoepidemiology of anemia in renal transplant recipients. J Am Soc Nephrol 2004;15:1347–52.Winkelmayer W.C., Kewalramani R., Rutstein M. et al. Pharmacoepidemiology of anemia in renal transplant recipients. J Am Soc Nephrol 2004;15:1347–52.Yorgin P.D., Scandling J.D., Belson A. et al. Late post-transplant anemia in adult renal transplant recipients. An underrecognized problem? Am J Transplant 2002;2:429–35.Yorgin P.D., Scandling J.D., Belson A. et al. Late post-transplant anemia in adult renal transplant recipients. An underrecognized problem? Am J Transplant 2002;2:429–35.Al-Uzri A., Yorgin P.D., Kling P.J. Anemia and the effect of immunosuppressive therapy on erythropoiesis. Pediatr Transplant 2003;7:253–64.Al-Uzri A., Yorgin P.D., Kling P.J. Anemia and the effect of immunosuppressive therapy on erythropoiesis. Pediatr Transplant 2003;7:253–64.Hricik D.E. Anemia after kidney transplantation: Is the incidence increasing? Am J Transplant 2003;3:771–2.Hricik D.E. Anemia after kidney transplantation: Is the incidence increasing? Am J Transplant 2003;3:771–2.Kamar N., Rostaying L. Negative impact of one-year anemia on long-tern patient and graft survival in kidney transplant patients receiving calcineurin inhibitors and mycofenolate mofetil. Transplantation 2008;85(8):1120–4.Kamar N., Rostaying L. Negative impact of one-year anemia on long-tern patient and graft survival in kidney transplant patients receiving calcineurin inhibitors and mycofenolate mofetil. Transplantation 2008;85(8):1120–4.Ersoy A., Kahvecioglu S., Ersoy C. et al. Anemia due to losartan in hypertensive renal transplant recipients without positive influence on blood pressure. Transplant Proc 2005;37:2148–50.Ersoy A., Kahvecioglu S., Ersoy C. et al. Anemia due to losartan in hypertensive renal transplant recipients without positive influence on blood pressure. Transplant Proc 2005;37:2148–50.Kasiske B.L., Vazquez M.A., Harmon W.E. et al. Recommendations for the outpatient surveillance of renal of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol 2000;11(Suppl 15):1–86.Kasiske B.L., Vazquez M.A., Harmon W.E. et al. Recommendations for the outpatient surveillance of renal of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol 2000;11(Suppl 15):1–86.Kim H.C., Park S.B., Han S.Y. et al. Anemia following renal transplantation. Transplant Proc 2003;35(1):302.Kim H.C., Park S.B., Han S.Y. et al. Anemia following renal transplantation. Transplant Proc 2003;35(1):302.Wilfingseder J., Kainz A., Perco P. et al. Molecular predictors for anemia after kidney transplantation. Nephrol Dial Transplant 2009;24(3):1015–23.Wilfingseder J., Kainz A., Perco P. et al. Molecular predictors for anemia after kidney transplantation. Nephrol Dial Transplant 2009;24(3):1015–23.Schwartz G.J., Gautier B.A. A simple estimate of glomerular filtration rate in adolescent boys. J Pediatr 1985;106:522–6.Schwartz G.J., Gautier B.A. A simple estimate of glomerular filtration rate in adolescent boys. J Pediatr 1985;106:522–6.Philipp S., Ollmann H., Schink T. et al. The impact of anemia and kidney function in congestive heart failure and preserved systolic function. Nephrol Dial Transplant 2005;20:915–9.Philipp S., Ollmann H., Schink T. et al. The impact of anemia and kidney function in congestive heart failure and preserved systolic function. Nephrol Dial Transplant 2005;20:915–9.Shah N., Al-khoury S., Afzali B. et al. Posttransplant anemia in adults renal allograft recipients: prevalence and predictors. Transplantation 2006;81(8):1112–8.Shah N., Al-khoury S., Afzali B. et al. Posttransplant anemia in adults renal allograft recipients: prevalence and predictors. Transplantation 2006;81(8):1112–8.Imoagene-Oyedeji A.E., Rosas S.E., Doyle A.M. et al. Posttransplantation anemia at 12 months in kidney recipients treated with mycophenolate mofetil: risk factors and implications for mortality. J Am Soc Nephrol 2006;17:3240–7.Imoagene-Oyedeji A.E., Rosas S.E., Doyle A.M. et al. Posttransplantation anemia at 12 months in kidney recipients treated with mycophenolate mofetil: risk factors and implications for mortality. J Am Soc Nephrol 2006;17:3240–7.Thaunat O., Beaumont C., Chatenoud L. et al. Anemia after late introduction of cirolimus may correlate with biochemical levidence of a chronic inflammatory state. Transplantation 2005;80(9):1212–9.Thaunat O., Beaumont C., Chatenoud L. et al. Anemia after late introduction of cirolimus may correlate with biochemical levidence of a chronic inflammatory state. Transplantation 2005;80(9):1212–9.Weiner D.E., Tighiouart H., Vlagopulos P.T. et al. Effects of anemia and left ventricular hypertrophy on cardiovascular disease in patients with chronic kidney disease. J Am Soc Nephrol 2005;16:1803–10.Weiner D.E., Tighiouart H., Vlagopulos P.T. et al. Effects of anemia and left ventricular hypertrophy on cardiovascular disease in patients with chronic kidney disease. J Am Soc Nephrol 2005;16:1803–10.Zadrail J., Horak P., Horika V. et al. Endogenous erythropoietin levels and anemia in long-term transplant recipients. Kidney Blood Press. Res 2007;30(30):106–16.Zadrail J., Horak P., Horika V. et al. Endogenous erythropoietin levels and anemia in long-term transplant recipients. Kidney Blood Press. Res 2007;30(30):106–16.Choukroun G., Deray G., Glotz D. et al. Incidence and management of anemia in renal transplantation : an observational-french study. Nephrol Ther 2008;4(7):575–83.Choukroun G., Deray G., Glotz D. et al. Incidence and management of anemia in renal transplantation : an observational-french study. Nephrol Ther 2008;4(7):575–83.Chhabra D., Grafals M., Scaro A.I. et al. Impact of anemia after renal transplantation on patients and graft survival and on rate of acute rejection. Clin J Am Soc Nephrol 2008;3:1168–74.Chhabra D., Grafals M., Scaro A.I. et al. Impact of anemia after renal transplantation on patients and graft survival and on rate of acute rejection. Clin J Am Soc Nephrol 2008;3:1168–74.Becker B.N., Becker I.T., Leverson G.E. et al. Erythropoietin therapy may retard progression in chronic renal transplant disfunction. Nephrol Dial Transplant 2002;17:1667–73.Becker B.N., Becker I.T., Leverson G.E. et al. Erythropoietin therapy may retard progression in chronic renal transplant disfunction. Nephrol Dial Transplant 2002;17:1667–73.Kahng K., Kang C., Kwak J. Changes in hemoglobin levels after renal transplantation. Transplant Proc 1998;30:3023–4.Kahng K., Kang C., Kwak J. Changes in hemoglobin levels after renal transplantation. Transplant Proc 1998;30:3023–4.Mix T.C., Kazmi W., Khan S. et al. Anemia: A continuing problem following kidney transplantation. Am J Transplant 2003;3:1426–33.Mix T.C., Kazmi W., Khan S. et al. Anemia: A continuing problem following kidney transplantation. Am J Transplant 2003;3:1426–33.Vanrenterghem I. Anemia after kidney transplantation. Transplantation 2009;87(9):1265–7.Vanrenterghem I. Anemia after kidney transplantation. Transplantation 2009;87(9):1265–7.Augustine J.J., Knauss T.C., Schulak J.A. et al. Comparative effects of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients. Am J Transplant 2004;4:2001–6.Augustine J.J., Knauss T.C., Schulak J.A. et al. Comparative effects of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patients. Am J Transplant 2004;4:2001–6.Yorgin P.D., Belson A., Sanchez J. et al. Unexpectedly high prevalence of posttransplant anemia in pediatric and young adult renal transplant recipients. Am J Kidney Dis 2002;40:1306–18.Yorgin P.D., Belson A., Sanchez J. et al. Unexpectedly high prevalence of posttransplant anemia in pediatric and young adult renal transplant recipients. Am J Kidney Dis 2002;40:1306–18.Afzali B., Al-Khoury S., Mikhail A. et al. Anemia after renal transplantation. Am J Kidney Dis 2006;48(4):519–36.Afzali B., Al-Khoury S., Mikhail A. et al. Anemia after renal transplantation. Am J Kidney Dis 2006;48(4):519–36.Sistani S., Gruber S., Amm J. et al. Anemia after kidney transplantation (KT): prevalence and risk factors. Transplantation 2004;78(2):287.Sistani S., Gruber S., Amm J. et al. Anemia after kidney transplantation (KT): prevalence and risk factors. Transplantation 2004;78(2):287.Mohanram A., Zhang Z., Shahinfar S. et al. Anemia and end-stage renal disease in patients renal disease in patients with type-2 diabetes and nephropathy. Kidney Int 2004;66:1131–8.Mohanram A., Zhang Z., Shahinfar S. et al. Anemia and end-stage renal disease in patients renal disease in patients with type-2 diabetes and nephropathy. Kidney Int 2004;66:1131–8.

The authors declare that there are no conflicts of interest present.