transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2010-0-1-61-67transplantologiya-272Research ArticleСЛУЧАЙ ИЗ ПРАКТИКИCASE REPORTКожная форма реакции «трансплантат против хозяина» у пациентки через 1 год после ортотопической трансплантации печени: описание случая и обзор литературыCutaneous graft-versus-host reaction in a female patient a year after orthotopic liver transplantation: a case report and a review of literatureСкворцоваЮ. В.SkvortsovaYu. V.

отделение трансплантации костного мозга

Bone Marrow Transplantation Unit

ОлисовО. Д.OlisovO. D.

Отделение трансплантации печени

Department of Renal Transplantation

СюткинВ. Е.SyutkinV. E.

Отделение трансплантации печени

Department of Renal Transplantation

КоноваловД. М.KonovalovD. M.ЧжаоА. В.ChzhaoA. V.

Отделение трансплантации печени 

Алексей Владимирович Чжао 

Department of Renal Transplantation

zhao@rambler.ruФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии; ФГУ Российская детская клиническая больницаРоссияFederal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology; Russian Pediatric Clinical HospitalRussian FederationНИИ скорой помощи им. Н.В. СклифосовскогоРоссияN.V. Sklifosovsky Research Institute of Emergency CareRussian FederationФГУ Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии; ГОУ ВПО РГМУРоссияFederal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology; Russian State Medical UniversityRussian Federation201017082018016167Copyright © Скворцова Ю.В., Олисов О.Д., Сюткин В.Е., Коновалов Д.М., Чжао А.В., 20182018Скворцова Ю.В., Олисов О.Д., Сюткин В.Е., Коновалов Д.М., Чжао А.В.Skvortsova Y.V., Olisov O.D., Syutkin V.E., Konovalov D.M., Chzhao A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/272

Изложен краткий обзор литературы с обсуждением основных принципов диагностики и лечения реакции «трансплантат против хозяина» (РТПХ). Частота данного осложнения после ортотопической трансплантации печени составляет 1 - 3%, смертность достигает 75%. В статье приведено клиническое наблюдение РТПХ после трансплантации печени, в клинике которой преобладали кожные проявления. Своевременная диагностика этого редкого осложнения позволила эффективно провести лечение пациентки.

The paper provides a brief overview of the data available in the literature with the discussion of the basic principles of the diagnosis and treatment of a graft-versus-host reaction (GVHR). After orthotopic liver transplantation, the incidence of this complication is 1–3%, mortality is as high as 75%. The paper describes a case of GVHR after liver transplantation, the clinical picture of which shows a preponderance of skin manifestations. Timely diagnosis of this rare complication has allowed the patient to be effectively treated.

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The authors declare that there are no conflicts of interest present.