transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2010-0-3-4-50-63transplantologiya-295Research ArticleРАЗНОЕMISCELLANEAСовременные подходы к отбору больных для трансплантации сердцаCurrent approaches to selecting patients for heart transplantationХубутияМ. Ш.KhubutiaM. Sh.ГиляревскийС. Р.GilyarevskyS. R.СоколовВ. В.SokolovV. V.

Виктор Викторович Соколов

nehotey@mail.ruКовалеваЕ. В.KovalevaE. V.КузьминаИ. М.KuzminaI. M.БойчевскаяЕ. И.BoichevskayaE. I.НИИ скорой помощи им. Н.В. СклифосовскогоРоссияN.V. Sklifosovsky Research Institute of Emergency CareRussian Federation20101708201803-45063Copyright © Хубутия М.Ш., Гиляревский С.Р., Соколов В.В., Ковалева Е.В., Кузьмина И.М., Бойчевская Е.И., 20182018Хубутия М.Ш., Гиляревский С.Р., Соколов В.В., Ковалева Е.В., Кузьмина И.М., Бойчевская Е.И.Khubutia M.S., Gilyarevsky S.R., Sokolov V.V., Kovaleva E.V., Kuzmina I.M., Boichevskaya E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/295

Представлен анализ современных подходов к отбору реципиентов для трансплантации сердца (ТС), а именно подходов к оценке тяжести сердечной недостаточности (СН), поскольку СН относится к наиболее частым показаниям к ТС. По мере увеличения доступности новых типов терапии и перехода имплантации механических устройств для вспомогательного кровообращения в разряд более стандартных вмешательств подходы к отбору больных будут совершенствоваться. С учетом недостатка донорских органов предполагается сохранение тенденции к выполнению ТС у наиболее тяжелых больных, которые нуждаются в длительном парентеральном применении препаратов с положительным инотропным действием и механической поддержке кровообращения.

The paper analyzes current approaches to selecting heart transplantation (HT) recipients, namely, approaches to assessing the severity of heart failure since the latter is the most common indication for HT. The approaches to selecting patients will be refined as the availability of new types of therapy increases and the implantation of mechanical extracorporeal circulation devices is ranked as a more standard intervention. With allowance made for the shortage of donor organs, it is anticipated that the trend in the performance of HT will persist in the most critically ill patients who need long-term parenteral use of positive inotropic drugs and mechanical circulation support.

трансплантация сердцасердечная недостаточностьмеханическое устройство для вспомогательного кровообращенияпрепараты с положительным инотропным действиемheart transplantationheart failuremechanical extracorporeal circulation deviceagents having positive inotropic actionReferencesDickstein K., Cohen-Solal A., Filippatos G. et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008;10:933–89.Dickstein K., Cohen-Solal A., Filippatos G. et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008;10:933–89.Jhund P.S., Macintyre K., Simpson C.R. et al. Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people. Circulation 2009; 119:515–23.Jhund P.S., Macintyre K., Simpson C.R. et al. Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people. Circulation 2009; 119:515–23.Shafazand M., Schaufelberger M., Lappas G. et al. Survival trends in men and women with heart failure of ischaemic and non-ischaemic origin: data for the period 1987–2003 from the Swedish Hospital Discharge Registry. Eur Heart J 2009; 30:671–8.Shafazand M., Schaufelberger M., Lappas G. et al. Survival trends in men and women with heart failure of ischaemic and non-ischaemic origin: data for the period 1987–2003 from the Swedish Hospital Discharge Registry. Eur Heart J 2009; 30:671–8.Gridelli B., Remuzzi G. Strategies for making more organs available for transplantation. N Engl J Med 2000;343:404–10.Gridelli B., Remuzzi G. Strategies for making more organs available for transplantation. N Engl J Med 2000;343:404–10.Costanzo M.R., Augustine S., Bourge R. et al. Selection and treatment of candidates for heart transplantation: a statement for health professionals from the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association. Circulation 1995; 92:3593–612.Costanzo M.R., Augustine S., Bourge R. et al. Selection and treatment of candidates for heart transplantation: a statement for health professionals from the Committee on Heart Failure and Cardiac Transplantation of the Council on Clinical Cardiology, American Heart Association. Circulation 1995; 92:3593–612.1999 Annual Report of the U.S. Scientific Registry of Transplant Recipients and the Organ Procurement and Transplantation Network: Transplant Data 1989–1998. Richmond, VA: HHS/GRSA/OSP/DOT and United Network for Organ Sharing, 1999.1999 Annual Report of the U.S. Scientific Registry of Transplant Recipients and the Organ Procurement and Transplantation Network: Transplant Data 1989–1998. Richmond, VA: HHS/GRSA/OSP/DOT and United Network for Organ Sharing, 1999.Mancini D., Lietz K. Selection of Cardiac Transplantation Candidates in 2010. Circulation 2010;122:173–83.Mancini D., Lietz K. Selection of Cardiac Transplantation Candidates in 2010. Circulation 2010;122:173–83.Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). 2007;2(28). http://www.intermacs.org/membership.aspxInteragency Registry for Mechanically Assisted Circulatory Support (INTERMACS). 2007;2(28). http://www.intermacs.org/membership.aspxStevenson L.W., Pagani F.D., Young J.B. et al. INTERMACS profiles of advanced heart failure: the current picture. J Heart Lung Transplant 2009;28:535–41.Stevenson L.W., Pagani F.D., Young J.B. et al. INTERMACS profiles of advanced heart failure: the current picture. J Heart Lung Transplant 2009;28:535–41.John R., Liao K., Lietz K. et al. Experience with the Levitronix CentriMag circulatory support system as a bridge to decision in patients with refractory acute cardiogenic shock and multisystem organ failure. J Thorac Cardiovasc Surg 2007;134:351–8.John R., Liao K., Lietz K. et al. Experience with the Levitronix CentriMag circulatory support system as a bridge to decision in patients with refractory acute cardiogenic shock and multisystem organ failure. J Thorac Cardiovasc Surg 2007;134:351–8.Acker M. Mechanical circulatory support for patients with acutefulminant myocarditis. Ann Thorac Surg 2001;71:73–6.Acker M. Mechanical circulatory support for patients with acutefulminant myocarditis. Ann Thorac Surg 2001;71:73–6.Alba A.C., Rao V., Ivanov J. et al. Usefulness of the INTERMACS scale to predict outcomes after mechanical assist device implantation. J Heart Lung Transplant 2009;28:827–33.Alba A.C., Rao V., Ivanov J. et al. Usefulness of the INTERMACS scale to predict outcomes after mechanical assist device implantation. J Heart Lung Transplant 2009;28:827–33.Lietz K., Deng M., Morgan J. et al. Selection of UNOS status 1A candidates for mechanical circulatory support as bridgetotransplantation (BTT): analysis of UNOS/ OPTN 2000–2005. J Heart Lung Transplant 2008;27:244. Abstr.Lietz K., Deng M., Morgan J. et al. Selection of UNOS status 1A candidates for mechanical circulatory support as bridgetotransplantation (BTT): analysis of UNOS/ OPTN 2000–2005. J Heart Lung Transplant 2008;27:244. Abstr.Lietz K., Long J.W., Kfoury A.G. et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation 2007;116:497–505.Lietz K., Long J.W., Kfoury A.G. et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation 2007;116:497–505.Patlolla V., Patten R., DeNofrio D. et al. The effect of ventricular assist devices on posttransplant mortality: an analysis of the United Network of Organ Sharing Thoracic Registry. J Am Coll Cardiol 2009;53:264–71.Patlolla V., Patten R., DeNofrio D. et al. The effect of ventricular assist devices on posttransplant mortality: an analysis of the United Network of Organ Sharing Thoracic Registry. J Am Coll Cardiol 2009;53:264–71.Rose E.A., Gelijns A.C., Moskowitz A.J. et al. for the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001;345:1435–43.Rose E.A., Gelijns A.C., Moskowitz A.J. et al. for the Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 2001;345:1435–43.Califf R., Adams K., McKenna W. et al. A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: the Flolan International Randomized Survival Trial (FIRST). Am Heart J 1997;134:44–54.Califf R., Adams K., McKenna W. et al. A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: the Flolan International Randomized Survival Trial (FIRST). Am Heart J 1997;134:44–54.Herschberger R., Nauman D., Walker T. et al. Care processes and clinical outcomes of continuous outpatient support with inotropes (COSI) in patients with refractory endstage heart failure. J Card Fail 2003;9:180–7.Herschberger R., Nauman D., Walker T. et al. Care processes and clinical outcomes of continuous outpatient support with inotropes (COSI) in patients with refractory endstage heart failure. J Card Fail 2003;9:180–7.Stevenson L. Clinical use of inotropic therapy for heart failure: looking backwards and forward, part II: chronic inotropic therapy. Circulation 2003;108:492–7.Stevenson L. Clinical use of inotropic therapy for heart failure: looking backwards and forward, part II: chronic inotropic therapy. Circulation 2003;108:492–7.Zimmermann N., Boknik P., Gams E. et al. Calcium sensitization as new principle of inotropic therapy in end-stage heart failure? Eur J Cardiothorac Surg 1998;14:70–5.Zimmermann N., Boknik P., Gams E. et al. Calcium sensitization as new principle of inotropic therapy in end-stage heart failure? Eur J Cardiothorac Surg 1998;14:70–5.Current U.S. Waiting list for heart transplant candidates: based on OPTN data as of January 1, 2007. 2009;6(1). http://www.optn.org/latestData/rptData.aspCurrent U.S. Waiting list for heart transplant candidates: based on OPTN data as of January 1, 2007. 2009;6(1). http://www.optn.org/latestData/rptData.aspStevenson L.W., Miller L.W., DesvigneNickens P. et al. Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure). Circulation 2004;110:975–81.Stevenson L.W., Miller L.W., DesvigneNickens P. et al. Left ventricular assist device as destination for patients undergoing intravenous inotropic therapy: a subset analysis from REMATCH (Randomized Evaluation of Mechanical Assistance in Treatment of Chronic Heart Failure). Circulation 2004;110:975–81.Slaughter M., Rogers J., Milano C. et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 2009;361:2241–51.Slaughter M., Rogers J., Milano C. et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 2009;361:2241–51.Fukamachi K., McCarthy P., Smedira N. et al. Pre-operative risk factors for right ventricular failure after implantable left ventricular device insertion. Ann Thorac Surg 1999;68:2181–4.Fukamachi K., McCarthy P., Smedira N. et al. Pre-operative risk factors for right ventricular failure after implantable left ventricular device insertion. Ann Thorac Surg 1999;68:2181–4.Ochiai Y., McCarthy P., Smedira N. et al. Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation 2002;106:II198–I202.Ochiai Y., McCarthy P., Smedira N. et al. Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation 2002;106:II198–I202.Kavarana M., Pessin-Minsley M., Urtecho J. et al. Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem. Ann Thorac Surg 2002;73:745–50.Kavarana M., Pessin-Minsley M., Urtecho J. et al. Right ventricular dysfunction and organ failure in left ventricular assist device recipients: a continuing problem. Ann Thorac Surg 2002;73:745–50.Matthews J.C., Koelling T.M., Pagani F.D. et al. The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates. J Am Coll Cardiol. 2008;51:2163–72.Matthews J.C., Koelling T.M., Pagani F.D. et al. The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates. J Am Coll Cardiol. 2008;51:2163–72.Fitzpatrick J.R. 3rd, Frederick J.R., Hsu V.M. et al. Risk score derived from preoperative data analysis predicts the need for biventricular mechanical circulatory support. J Heart Lung Transplant 2008;27:1286–92.Fitzpatrick J.R. 3rd, Frederick J.R., Hsu V.M. et al. Risk score derived from preoperative data analysis predicts the need for biventricular mechanical circulatory support. J Heart Lung Transplant 2008;27:1286–92.Itescu S., John R. Interactions between the recipient immune system and LVAD surface: immunological and clinical implications. Ann Thorac Surg 2003;75:58–65.Itescu S., John R. Interactions between the recipient immune system and LVAD surface: immunological and clinical implications. Ann Thorac Surg 2003;75:58–65.Taylor D., Stehlik J., Edwards L. et al. Registry of the International Society for Heart and Lung Transplantation: twenty-sixth official adult heart transplant report: 2009. J Heart Lung Transplant 2009;28:1007–22.Taylor D., Stehlik J., Edwards L. et al. Registry of the International Society for Heart and Lung Transplantation: twenty-sixth official adult heart transplant report: 2009. J Heart Lung Transplant 2009;28:1007–22.Klovaite J., Gustafsson F., Mortensen S. et al. Severely impaired von Willebrand factor dependent platelet aggregation in patients with a continuous flow left ventricular assist device (Heartmate II). J Am Coll Cardiol 2009;53:2162–7.Klovaite J., Gustafsson F., Mortensen S. et al. Severely impaired von Willebrand factor dependent platelet aggregation in patients with a continuous flow left ventricular assist device (Heartmate II). J Am Coll Cardiol 2009;53:2162–7.Mancini D., Eisen H., Kussmaul W. et al. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 1991;83:778–86.Mancini D., Eisen H., Kussmaul W. et al. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation 1991;83:778–86.Guazzi M., Myers J., Abella J., et al. The added prognostic value of ventilatory efficiency to the Weber classification in patients with heart failure. Int J Cardiol 2008;129:86–92.Guazzi M., Myers J., Abella J., et al. The added prognostic value of ventilatory efficiency to the Weber classification in patients with heart failure. Int J Cardiol 2008;129:86–92.Lang C., Karlin P., Haythe J. et al. Peak cardiac power output measured non-invasively, is a powerful predictor of outcome in chronic heart failure. Circ Heart Fail 2009;2:33–8.Lang C., Karlin P., Haythe J. et al. Peak cardiac power output measured non-invasively, is a powerful predictor of outcome in chronic heart failure. Circ Heart Fail 2009;2:33–8.Aaronson K., Mancini D. Is percent predicted VO2 a better selection criterion than peak VO2 for cardiac transplantation? J Heart Lung Transplant 1995;14:981–9.Aaronson K., Mancini D. Is percent predicted VO2 a better selection criterion than peak VO2 for cardiac transplantation? J Heart Lung Transplant 1995;14:981–9.Aaronson K., Schwartz J.S., Chen T. et al. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation 1997;95:2660–7.Aaronson K., Schwartz J.S., Chen T. et al. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation 1997;95:2660–7.Lund L., Aaronson K., Mancini D. Predicting survival in ambulatory patients with severe heart failure on beta blocker therapy. Am J Cardiol 2003;92:1350–4.Lund L., Aaronson K., Mancini D. Predicting survival in ambulatory patients with severe heart failure on beta blocker therapy. Am J Cardiol 2003;92:1350–4.Koelling T., Joseph S., Aaronson K. Heart Failure Survival Score continues to predict outcomes in patients receiving beta blockers. J heart Lung Transplant 2004;23:1414–22.Koelling T., Joseph S., Aaronson K. Heart Failure Survival Score continues to predict outcomes in patients receiving beta blockers. J heart Lung Transplant 2004;23:1414–22.O’Neill J., Young J., Pothier C. et al. Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta blockers. Circulation 2005;111:2313–8.O’Neill J., Young J., Pothier C. et al. Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta blockers. Circulation 2005;111:2313–8.Lund L., Aaronson K., Mancini D. Validation of Peak VO2 and the Heart Failure Survival Score for serial risk stratification in advanced heart failure. J Am Cardiol 2005;95:734–41.Lund L., Aaronson K., Mancini D. Validation of Peak VO2 and the Heart Failure Survival Score for serial risk stratification in advanced heart failure. J Am Cardiol 2005;95:734–41.Levy W.C., Mozaffarian D., Linker D.T. et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation 2006;113:1424–33.Levy W.C., Mozaffarian D., Linker D.T. et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation 2006;113:1424–33.Gorodeski E.Z., Chu E.C., Chow C.H. et al. Application of the Seattle Heart Failure Model in Ambulatory Patients Presented to an Advanced Heart Failure Therapeutics Committee. Circ Heart Fail 2010;8(26).Gorodeski E.Z., Chu E.C., Chow C.H. et al. Application of the Seattle Heart Failure Model in Ambulatory Patients Presented to an Advanced Heart Failure Therapeutics Committee. Circ Heart Fail 2010;8(26).De Meester J.M., Smits J.M., Heinecke J. et al. Effect of receiving a heart transplant: analysis of a national cohort entered on to a waiting list, stratified by heart failure severity: Comparative Outcome and Clinical Profiles in Transplantation (COCPIT) Study Group. BMJ 2000;321:540–5.De Meester J.M., Smits J.M., Heinecke J. et al. Effect of receiving a heart transplant: analysis of a national cohort entered on to a waiting list, stratified by heart failure severity: Comparative Outcome and Clinical Profiles in Transplantation (COCPIT) Study Group. BMJ 2000;321:540–5.Jimenez J., Bennett-Edwards L., Higgins R. et al. Should we transplant UNOS status 2 patients? J Heart Lung Transplant 2005;24:178–83.Jimenez J., Bennett-Edwards L., Higgins R. et al. Should we transplant UNOS status 2 patients? J Heart Lung Transplant 2005;24:178–83.Kirklin J.K., Naftel D.C., Caldwell R. et al. Should status 2 patients be removed from the pediatric heart transplant waiting list? A multiinstitutional study. J Heart Lung Transplant 2006;25:271–5.Kirklin J.K., Naftel D.C., Caldwell R. et al. Should status 2 patients be removed from the pediatric heart transplant waiting list? A multiinstitutional study. J Heart Lung Transplant 2006;25:271–5.Deng M.C., Smits J.M., Young J.B. Proposition: the benefit of cardiac transplantation in stable outpatients with heart failure should be tested in a randomized trial. J Heart Lung Transplant 2003;22:113–7.Deng M.C., Smits J.M., Young J.B. Proposition: the benefit of cardiac transplantation in stable outpatients with heart failure should be tested in a randomized trial. J Heart Lung Transplant 2003;22:113–7.Mokadam N.A., Ewald G.A., Damiano R.J. et al. Deterioration and mortality among patient with United Network for Organ Sharing status 2 heart disease: caution must be exercised in diverting organs. J Thorac Cardiovasc Surgery 2006;131:925–6.Mokadam N.A., Ewald G.A., Damiano R.J. et al. Deterioration and mortality among patient with United Network for Organ Sharing status 2 heart disease: caution must be exercised in diverting organs. J Thorac Cardiovasc Surgery 2006;131:925–6.Mehra M., Kobashigawa J., Starling R. et al. Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation Guidelines for the care of cardiac transplant candidates: 2006 . J Heart Lung Transplant 2006;25:1024–42.Mehra M., Kobashigawa J., Starling R. et al. Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation Guidelines for the care of cardiac transplant candidates: 2006 . J Heart Lung Transplant 2006;25:1024–42.Aurora P., Edwards L., Christie J. et al. Registry of the International Society for Heart and Lung Transplantation: eleventh official pediatric lung and heart/lung transplantation report: 2008 . J Heart Lung Transplant 2008;27:978–83.Aurora P., Edwards L., Christie J. et al. Registry of the International Society for Heart and Lung Transplantation: eleventh official pediatric lung and heart/lung transplantation report: 2008 . J Heart Lung Transplant 2008;27:978–83.Morgan J.A., John R., Mancini D.M. et al. Should heart transplantation be considered as a treatment option for patients aged 70 years and older? J Thorac Cardiovasc Surg 2004;127:1817–9.Morgan J.A., John R., Mancini D.M. et al. Should heart transplantation be considered as a treatment option for patients aged 70 years and older? J Thorac Cardiovasc Surg 2004;127:1817–9.Morgan J.A., John R., Weinberg A.D. et al. Long-term results of cardiac transplantation in patients 65 years of age and older: a comparative analysis. Ann Thorac Surg 2003;76:1982–7.Morgan J.A., John R., Weinberg A.D. et al. Long-term results of cardiac transplantation in patients 65 years of age and older: a comparative analysis. Ann Thorac Surg 2003;76:1982–7.Weiss E.S., Nwakanma L.U., Patel N.D. et al. Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database. J Heart Lung Transplant 2008;27:184–91.Weiss E.S., Nwakanma L.U., Patel N.D. et al. Outcomes in patients older than 60 years of age undergoing orthotopic heart transplantation: an analysis of the UNOS database. J Heart Lung Transplant 2008;27:184–91.Tjang Y.S., van der Heijden G.J., Tenderich G. et al. Impact of recipient’s age on heart transplantation outcome. Ann Thorac Surg 2008;85:2051–5.Tjang Y.S., van der Heijden G.J., Tenderich G. et al. Impact of recipient’s age on heart transplantation outcome. Ann Thorac Surg 2008;85:2051–5.Marielli D., Kobashigawa J., Hamilton M. et al. Long term outcomes of heart transplantation in older recipients. J Heart Lung Transplant 2008;27:830–4.Marielli D., Kobashigawa J., Hamilton M. et al. Long term outcomes of heart transplantation in older recipients. J Heart Lung Transplant 2008;27:830–4.Murali S., Kormos R., Uretsky B. et al. Preoperative pulmonary hemodynamics and early mortality after orthotopic cardiac transplantation: the Pittsburgh experience. Am Heart J 1993;126:896–904.Murali S., Kormos R., Uretsky B. et al. Preoperative pulmonary hemodynamics and early mortality after orthotopic cardiac transplantation: the Pittsburgh experience. Am Heart J 1993;126:896–904.Chen J., Levin H., Michler R. et al. Reevaluating the significance of pulmonary hypertension before cardiac transplantation: determination of optimal thresholds and quantification of the effect of reversibility on peri-operative mortality. J Thorac Cardiovasc Surg 1997;114:627–34.Chen J., Levin H., Michler R. et al. Reevaluating the significance of pulmonary hypertension before cardiac transplantation: determination of optimal thresholds and quantification of the effect of reversibility on peri-operative mortality. J Thorac Cardiovasc Surg 1997;114:627–34.Lindelow B., Anderson B., Waagstein F. et al. High and low pulmonary vascular resistance in heart transplant candidates. Eur Heart J 1999;20:148–56.Lindelow B., Anderson B., Waagstein F. et al. High and low pulmonary vascular resistance in heart transplant candidates. Eur Heart J 1999;20:148–56.The Registry of the International Society for Heart and Lung Transplantation. 2009;6(1). http://www.ishlt.org/registries/slidesThe Registry of the International Society for Heart and Lung Transplantation. 2009;6(1). http://www.ishlt.org/registries/slidesZimpler D., Zrunek P., Sandner S. et al. Post transplant survival after lowering pulmonary hypertension using left ventricular assist devices. J Cardiothorac Surg 2007;31:698–702.Zimpler D., Zrunek P., Sandner S. et al. Post transplant survival after lowering pulmonary hypertension using left ventricular assist devices. J Cardiothorac Surg 2007;31:698–702.Etz C., Welp H., Tjan T. et al. Medically refractory pulmonary hypertension: treatment with non pulsatile left ventricular assist devices. Ann Thorac Surg 2007;83:1697–706.Etz C., Welp H., Tjan T. et al. Medically refractory pulmonary hypertension: treatment with non pulsatile left ventricular assist devices. Ann Thorac Surg 2007;83:1697–706.Lang C., Beniaminovitz A., Edwards N. et al. Morbidity and mortality in diabetic patients following cardiac transplantation. J Heart Lung Transplant 2003;22:244–9.Lang C., Beniaminovitz A., Edwards N. et al. Morbidity and mortality in diabetic patients following cardiac transplantation. J Heart Lung Transplant 2003;22:244–9.Cimato T., Jessup M. Recipient selection in cardiac transplantation: contraindications and risk factors for mortality. J Heart Lung Transplant 2002;21:1161–73.Cimato T., Jessup M. Recipient selection in cardiac transplantation: contraindications and risk factors for mortality. J Heart Lung Transplant 2002;21:1161–73.Russo M., Chen J., Hong K. et al. Survival after heart transplantation is not diminished among recipients with uncomplicated diabetes mellitus: an analysis of the United Network of Organ Sharing Database. Circulation 2006;114:2280–7.Russo M., Chen J., Hong K. et al. Survival after heart transplantation is not diminished among recipients with uncomplicated diabetes mellitus: an analysis of the United Network of Organ Sharing Database. Circulation 2006;114:2280–7.Almuti K., Haythe J., Tsao L. et al. Does renal function deteriorate more rapidly in diabetic cardiac transplant recipients? Transplantation 2007;83:550–3.Almuti K., Haythe J., Tsao L. et al. Does renal function deteriorate more rapidly in diabetic cardiac transplant recipients? Transplantation 2007;83:550–3.Russo M., Rana A., Chen J. et al. Pretransplantation patient characteristics and survival following combined heart and kidney transplantation. Arch Surg 2009;144:241–6.Russo M., Rana A., Chen J. et al. Pretransplantation patient characteristics and survival following combined heart and kidney transplantation. Arch Surg 2009;144:241–6.Porter K., Babiker A., Bhaskaran K. et al. Determinants of survival following HIV-1 seroconversion after the introduction of HAART. Lancet 2003;362:1267–74.Porter K., Babiker A., Bhaskaran K. et al. Determinants of survival following HIV-1 seroconversion after the introduction of HAART. Lancet 2003;362:1267–74.Sackoff J.E., Hanna D.B., Pfeiffer M.R. et al. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med 2006;145:397–406.Sackoff J.E., Hanna D.B., Pfeiffer M.R. et al. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med 2006;145:397–406.Calabrese L.H., Albrecht M., Young J. et al. Successful cardiac transplantation in an HIV-1-infected patient with advanced disease. N Engl J Med 2003;348:2323–8.Calabrese L.H., Albrecht M., Young J. et al. Successful cardiac transplantation in an HIV-1-infected patient with advanced disease. N Engl J Med 2003;348:2323–8.Gupta S., Markham D.W., Mammen P.P. et al. Long-term follow-up of a heart transplant recipient with documented seroconversion to HIV-positive status 1 year after transplant. Am J Transplant 2008;8:893–6.Gupta S., Markham D.W., Mammen P.P. et al. Long-term follow-up of a heart transplant recipient with documented seroconversion to HIV-positive status 1 year after transplant. Am J Transplant 2008;8:893–6.Uriel N., Jorde U.P., Cotarlan V. et al. Heart transplantation in human immunodeficiency virus-positive patients. J Heart Lung Transplant 2009;28:667–9.Uriel N., Jorde U.P., Cotarlan V. et al. Heart transplantation in human immunodeficiency virus-positive patients. J Heart Lung Transplant 2009;28:667–9.Hosenpud J., DeMarco T., Frazier O.H. et al. Progression of systemic disease and reduced long-term survival in patients with cardiac amyloidosis undergoing heart transplantation: follow-up results of a multicenter survey. Circulation 1991;84(Suppl):III338–43.Hosenpud J., DeMarco T., Frazier O.H. et al. Progression of systemic disease and reduced long-term survival in patients with cardiac amyloidosis undergoing heart transplantation: follow-up results of a multicenter survey. Circulation 1991;84(Suppl):III338–43.Dubrey S., Burke M., Hawkins P. et al. Cardiac transplantation for amyloid heart disease: the United Kingdom experience. J Heart Lung Transplant 2004;23:1142–53.Dubrey S., Burke M., Hawkins P. et al. Cardiac transplantation for amyloid heart disease: the United Kingdom experience. J Heart Lung Transplant 2004;23:1142–53.Maurer M., Raina A., Hesdorffer C. et al. Preliminary experience of cardiac transplantation using extended donor organs for systemic amyloidosis complicated by heart failure. Transplantation 2007;83:539–45.Maurer M., Raina A., Hesdorffer C. et al. Preliminary experience of cardiac transplantation using extended donor organs for systemic amyloidosis complicated by heart failure. Transplantation 2007;83:539–45.Hamour I., Lachmann H., Goodman H. et al. Heart transplantation for homozygous familial transthyretin (TTR) V 1221 cardiac amyloidosis. Am J Transplant 2008;8:1056–9.Hamour I., Lachmann H., Goodman H. et al. Heart transplantation for homozygous familial transthyretin (TTR) V 1221 cardiac amyloidosis. Am J Transplant 2008;8:1056–9.Sack F., Kristen A., Goldschmidt H. et al. Treatment options for severe cardiac amyloidosis: heart transplantation combined with chemotherapy and stem cell transplantation for patients with AL amyloidosis and heart and liver transplantation for patients with ATTR-amyloidosis. Eur J Cardiothorac Surg 2008;33:257–62.Sack F., Kristen A., Goldschmidt H. et al. Treatment options for severe cardiac amyloidosis: heart transplantation combined with chemotherapy and stem cell transplantation for patients with AL amyloidosis and heart and liver transplantation for patients with ATTR-amyloidosis. Eur J Cardiothorac Surg 2008;33:257–62.Surakomol S., Olson L.J., Rastogi A. et al. Combined orthotopic heart and liver transplantation for genetic hemochromatosis. J Heart Lung Transplant 1997;16:573–5.Surakomol S., Olson L.J., Rastogi A. et al. Combined orthotopic heart and liver transplantation for genetic hemochromatosis. J Heart Lung Transplant 1997;16:573–5.Hsu R.B., Chang C.I., Lin F.Y. et al. Heart transplantation in patients with liver cirrhosis. Eur J Cardiothorac Surg 2008;34:307–12.Hsu R.B., Chang C.I., Lin F.Y. et al. Heart transplantation in patients with liver cirrhosis. Eur J Cardiothorac Surg 2008;34:307–12.Laks H., Marelli D., Fonarow G. et al. Use of two recipient lists for adults requiring heart transplantation. J Thorac Cardiovasc Surg 2003;125:49–59.Laks H., Marelli D., Fonarow G. et al. Use of two recipient lists for adults requiring heart transplantation. J Thorac Cardiovasc Surg 2003;125:49–59.Chen J., Russo M., Hammond K. et al. Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann Thorac Surg 2005;80:224–8.Chen J., Russo M., Hammond K. et al. Alternate waiting list strategies for heart transplantation maximize donor organ utilization. Ann Thorac Surg 2005;80:224–8.Shivalkar B., Van Loon J., Wieland W. et al. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 1993;87:230–9.Shivalkar B., Van Loon J., Wieland W. et al. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 1993;87:230–9.Stoica S.C., Satchihananda D.K., White P.A. et al. Brain death leads to abnormal contractile properties of the human donor right ventricle. J Thorac Cardiovasc Surg 2006;132:116–23.Stoica S.C., Satchihananda D.K., White P.A. et al. Brain death leads to abnormal contractile properties of the human donor right ventricle. J Thorac Cardiovasc Surg 2006;132:116–23.Novitzky D. Detrimental effects of brain death on the potential organ donor. Transplant Proc 1997;29:3770–2.Novitzky D. Detrimental effects of brain death on the potential organ donor. Transplant Proc 1997;29:3770–2.Taylor D.O., Edwards L.B., Aurora P. et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth Official Adult Heart Transplant Report–2008. Heart Lung Transplant 2008;27:943–56.Taylor D.O., Edwards L.B., Aurora P. et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fifth Official Adult Heart Transplant Report–2008. Heart Lung Transplant 2008;27:943–56.Berman M., Ali A., Ashley E. et al. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant 2010; 29:957–65.Berman M., Ali A., Ashley E. et al. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant 2010; 29:957–65.Stoica S.C., Satchihananda D.K., White P.A. et al. Noradrenaline use in human donor and relationship with load-independent right ventricular contractility. Transplantation 2004;78:1193–7.Stoica S.C., Satchihananda D.K., White P.A. et al. Noradrenaline use in human donor and relationship with load-independent right ventricular contractility. Transplantation 2004;78:1193–7.Bittner H.B., Kendall S.W., Chen E.P. et al. The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation. J Heart Lung Transplant 1996;15:764–77.Bittner H.B., Kendall S.W., Chen E.P. et al. The combined effects of brain death and cardiac graft preservation on cardiopulmonary hemodynamics and function before and after subsequent heart transplantation. J Heart Lung Transplant 1996;15:764–77.Kendall S.W., Bittner H.B., Peterseim D.S. et al. Right ventricular function in the donor heart. Eur J Cardiothorac Surg 1997; 11:609–15.Kendall S.W., Bittner H.B., Peterseim D.S. et al. Right ventricular function in the donor heart. Eur J Cardiothorac Surg 1997; 11:609–15.Bittner H.B., Chen E.P., Biswas S.S. et al. Right ventricular dysfunction after cardiac transplantation: primarily related to the status of donor heart. Ann Thorac Surg 1999;68:1605–11.Bittner H.B., Chen E.P., Biswas S.S. et al. Right ventricular dysfunction after cardiac transplantation: primarily related to the status of donor heart. Ann Thorac Surg 1999;68:1605–11.Talaj J.A., Kirklin J.A., Brown R.N. et al. Post-heart transplant diastolic dysfunction is a risk factor for mortality. J Am Coll Cardiology 2007;50:1064–9.Talaj J.A., Kirklin J.A., Brown R.N. et al. Post-heart transplant diastolic dysfunction is a risk factor for mortality. J Am Coll Cardiology 2007;50:1064–9.Berman M., Ali A., Ashley E. et al. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant 2010;29:957–65.Berman M., Ali A., Ashley E. et al. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant 2010;29:957–65.Copeland J.G., Griepp R.B., Bieber C.P. et al. Successful retransplantation of the human heart. J Thorac Cardiovasc Surg 1977; 73:242–7.Copeland J.G., Griepp R.B., Bieber C.P. et al. Successful retransplantation of the human heart. J Thorac Cardiovasc Surg 1977; 73:242–7.Tjang Y.S., Tenderich G., Hornik L. et al. Cardiac retransplantation in adults: an evidence-based systematic review. Thorac Cardiovasc Surg 2008;56:323–7.Tjang Y.S., Tenderich G., Hornik L. et al. Cardiac retransplantation in adults: an evidence-based systematic review. Thorac Cardiovasc Surg 2008;56:323–7.Srivastava R., Keck B.M., Bennett L.E. et al. The results of cardiac retransplantation: an analysis of the Joint International Society for Heart and Lung Transplantation/United Network for Organ Sharing Thoracic Registry. Transplantation 2000;70:606–12.Srivastava R., Keck B.M., Bennett L.E. et al. The results of cardiac retransplantation: an analysis of the Joint International Society for Heart and Lung Transplantation/United Network for Organ Sharing Thoracic Registry. Transplantation 2000;70:606–12.Topkara V.K., Dang N.C., John R. et al. A decade experience of cardiac retransplantation in adult recipients. J Heart Lung Transplant 2005;24:1745–50.Topkara V.K., Dang N.C., John R. et al. A decade experience of cardiac retransplantation in adult recipients. J Heart Lung Transplant 2005;24:1745–50.Magee J.C., Barr M.L., Basadonna G.P. et al. Repeat organ transplantation in the United States, 1996–2005. Am J Transplant 2007;71424–33.Magee J.C., Barr M.L., Basadonna G.P. et al. Repeat organ transplantation in the United States, 1996–2005. Am J Transplant 2007;71424–33.Karwande S.V., Ensley R.D., Renlund D.G. et al. Cardiac retransplantation: a viable option? The Registry of the International Society for Heart and Lung Transplantation. Ann Thorac Surg 1992;54:840–4.Karwande S.V., Ensley R.D., Renlund D.G. et al. Cardiac retransplantation: a viable option? The Registry of the International Society for Heart and Lung Transplantation. Ann Thorac Surg 1992;54:840–4.Schnetzler B., Pavie A., Dorent R. et al. Heart retransplantation: a 23-year singlecenter clinical experience. Ann Thorac Surg 1998;65:978–83.Schnetzler B., Pavie A., Dorent R. et al. Heart retransplantation: a 23-year singlecenter clinical experience. Ann Thorac Surg 1998;65:978–83.Smith J.A., Ribakove G.H., Hunt S.A. et al. Heart retransplantation: the 25-year experience at a single institution. J Heart Lung Transplant 1995;14:832–9.Smith J.A., Ribakove G.H., Hunt S.A. et al. Heart retransplantation: the 25-year experience at a single institution. J Heart Lung Transplant 1995;14:832–9.Chin C., Naftel D., Pahl E. et al. Cardiac Re-transplantation in pediatrics: a multiinstitutional study. J Heart Lung Transplant 2006;25:1420–4.Chin C., Naftel D., Pahl E. et al. Cardiac Re-transplantation in pediatrics: a multiinstitutional study. J Heart Lung Transplant 2006;25:1420–4.John R., Chen J.M., Weinberg A. et al. Long-term survival after cardiac retransplantation: a twenty-year singlecenter experience. J Thorac Cardiovasc Surg 1999;117:543–55.John R., Chen J.M., Weinberg A. et al. Long-term survival after cardiac retransplantation: a twenty-year singlecenter experience. J Thorac Cardiovasc Surg 1999;117:543–55.Tsao L., Uriel N., Leitz K. et al. Higher rate of co-morbidities post cardiac retransplantation contribute to decreased survival. J Heart Lung Transplant 2009;28:1072–4.Tsao L., Uriel N., Leitz K. et al. Higher rate of co-morbidities post cardiac retransplantation contribute to decreased survival. J Heart Lung Transplant 2009;28:1072–4.Johnson M.R., Aaronson K.D., Canter C.E. et al. Heart retransplantation. Am J Transplant 2007;7:2075–81.Johnson M.R., Aaronson K.D., Canter C.E. et al. Heart retransplantation. Am J Transplant 2007;7:2075–81.Chen J., Davies R., Mital S. et al. Trends and outcomes in transplantation for complex congenital heart disease: 1984–2004. Ann Thoracic Surg 2004;78:1352–61.Chen J., Davies R., Mital S. et al. Trends and outcomes in transplantation for complex congenital heart disease: 1984–2004. Ann Thoracic Surg 2004;78:1352–61.Lamour J., Kanter K., Naftel D. et al. The effect of age, diagnosis, and previous surgery in children and adults undergoing heart transplantation for congenital heart disease. J Am Coll Cardiol 2009;54:160–5.Lamour J., Kanter K., Naftel D. et al. The effect of age, diagnosis, and previous surgery in children and adults undergoing heart transplantation for congenital heart disease. J Am Coll Cardiol 2009;54:160–5.Patel N.D., Weiss E.S., Allen J.G. et al. Heart transplantation for adults with congenital heart disease: analysis of the United Network for Organ Sharing database. Ann Thorac Surg 2009;8:814–21.Patel N.D., Weiss E.S., Allen J.G. et al. Heart transplantation for adults with congenital heart disease: analysis of the United Network for Organ Sharing database. Ann Thorac Surg 2009;8:814–21.

The authors declare that there are no conflicts of interest present.