transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2011-0-4-37-40transplantologiya-322Research ArticleДИАГНОСТИКАDIAGNOSTICSМетоды определения сенсибилизации к HLA у реципиентов из "листа ожидания" на трансплантацию органовMethods to determine the sensitization to HLA in the recipients on the waiting list for organ transplantationБоровковаН. В.BorovkovaN. V.borovkovanv@yandex.ruДоронинаН. В.DoroninaN. V.МуштаН. А.MushN. A.НИИ скорой помощи им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute for Emergency MedicineRussian Federation201121082018043740Copyright © Боровкова Н.В., Доронина Н.В., Мушта Н.А., 20182018Боровкова Н.В., Доронина Н.В., Мушта Н.А.Borovkova N.V., Doronina N.V., Mush N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/322

Проведен сравнительный анализ двух методов выявления сенсибилизации реципиентов к HLA - традиционного серологического метода, основанного на лимфоцитотоксическом тесте и метода мультиплексного анализа с детекцией результатов исследования на платформе Luminex. Выявлены высокая чувствительность и информативность метода определения антител к HLA на платформе Luminex.

The comparative analysis of two methods of exposure of sensitization of recipients to HLA is conducted - traditional serum method, based on a limphocytotoxicity test, and the method of multiplexed analysis with the detection of results using the Luminex platform. A high sensitiveness and informing of method of antibodies determination to HLA using the Luminex platform is demonstrated.

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The authors declare that there are no conflicts of interest present.