transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2011-0-2-3-29-33transplantologiya-332Research ArticleДИАГНОСТИКА И ПРОГНОЗИРОВАНИЕDIAGNOSIS AND PREDICTIONОценка состояния и качества лечения пациентов после трансплантации почки с помощью мониторинга редокс-потенциала сыворотки кровиAssessment of the state and quality of treatment in posttransplant kidney patients, by monitoring the serum redox potentialПинчукА. В.PinchukA. V.АлександроваИ. В.AleksandrovaI. V.ГольдинМ. М.GoldinM. M.

Марк Михайлович Гольдин

markmgold@gmail.comЕвсеевА. К.EvseyevA. K.СорокинБ. А.SorokinB. A.НИИ скорой помощи им. Н.В. СклифосовскогоРоссияResearch Institute for Emergency named after N.V. SklifosovskyRussian Federation20112108201802-32933Copyright © Пинчук А.В., Александрова И.В., Гольдин М.М., Евсеев А.К., Сорокин Б.А., 20182018Пинчук А.В., Александрова И.В., Гольдин М.М., Евсеев А.К., Сорокин Б.А.Pinchuk A.V., Aleksandrova I.V., Goldin M.M., Evseyev A.K., Sorokin B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/332

Ранее с помощью мониторинга редокс-потенциала сыворотки крови пациентов после трансплантации печени была обнаружена возможность проведения ранней неинвазивной диагностики острой дисфункции трансплантата за счет фиксирования сдвигов измеряемого потенциала. Нами исследованы сдвиги стационарных потенциалов платинового электрода при лечении пациентов после трансплантации почки. Установлено, что сдвиг редокс-потенциала сыворотки крови > 25 мВ свидетельствует о начале процесса дисфункции трансплантата, также он может быть связан с иными осложнениями или передозировкой лекарственных препаратов. Выявлена связь сдвигов величин редокс-потенциала с результатами лечения методом плазмафереза у пациентов указанной группы.

Monitoring the serum redox potential (RP) in posttransplant liver patients has previously shown that the early noninvasive diagnosis of acute graft dysfunction could be made by recording the changes in the potential measured. The changes in the steady-state potentials of a platinum electrode were studied in the treatment of patients after kidney transplantation. It has been established that the serum RP change of > 25 mW is indicative of the onset of graft dysfunction and it may be also associated with other complications or drug overdosage. An association was found between the changes in RP values and the results of treatment with plasmapheresis in the above group of patients.

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The authors declare that there are no conflicts of interest present.