transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2012-0-3-15-21transplantologiya-354Research ArticleАКТУАЛЬНЫЕ ВОПРОСЫ ТРАНСПЛАНТОЛОГИИACTUAL ISSUES OF TRANSPLANTATIONОтдаленные результаты трансплантации печени при гепатоцеллюлярном ракеLong-term results of liver transplantation for hepatocellular carcinomaХубутияМ. Ш.KhubutiaM. Sh.КоваленкоЮ. А.KovalenkoY. A.

Юрий Алексеевич Коваленко

Kovalenkoya@rambler.ruЧугуновА. О.ChugunovA. O.ЧжаоА. В.ChzhaoA. V.ДжаграевК. Р.DzhagraevK. R.СалиенкоА. А.SalienkoA. A.АндрейцеваО. И.AndreytsevaO. I.ДоноваЛ. В.DonovaL. V.НИИ скорой помощи им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute for Emergency MedicineRussian Federation201224082018031521Copyright © Хубутия М.Ш., Коваленко Ю.А., Чугунов А.О., Чжао А.В., Джаграев К.Р., Салиенко А.А., Андрейцева О.И., Донова Л.В., 20182018Хубутия М.Ш., Коваленко Ю.А., Чугунов А.О., Чжао А.В., Джаграев К.Р., Салиенко А.А., Андрейцева О.И., Донова Л.В.Khubutia M.S., Kovalenko Y.A., Chugunov A.O., Chzhao A.V., Dzhagraev K.R., Salienko A.A., Andreytseva O.I., Donova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/354

На основании наибольшего опыта трансплантации печени при гепатоцеллюлярном раке в России сформулирован новый подход к трансплантации с обоснованием необходимости создания парадигмы прогноза рецидива на дооперационном этапе. Проведен регрессионный анализ влияния на выживаемость основных клинико-патологических факторов, определяющих показания к трансплантации печени. Показана перспектива использования молекулярных критериев для отбора больных на трансплантацию печени.

In this article we presented the new approach to the liver transplantation based on the prognosis paradigm of the tumor recurrence before the operation using largest experience of the liver transplantation in Russia. The effect independent clinicopathologic factors on outcome were tested using univariate and multivariate analyses by the Cox regression. The value molecular biomarker for choice of the patients to the transplantation liver was presented.

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The authors declare that there are no conflicts of interest present.