transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2012-0-1-2-10-14transplantologiya-373Research ArticleАКТУАЛЬНЫЕ ВОПРОСЫ ТРАНСПЛАНТОЛОГИИACTUAL ISSUES OF TRANSPLANTATIONОпыт применения эверолимуса у больных, перенесших ортотопическую трансплантацию печениThe experience of use of everolimus in patients having undergone to orthotopic liver transplantationСюткинВ. Е.SyutkinV. E.vladsyutkin@mail.ruАндрейцеваО. И.AndreytsevaO. I.НикулинаВ. П.NikulinaV. P.ЧугуновА. О.ChugunovA. O.НИИ СП им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute for Emergency MedicineRussian Federation20122408201801-21014Copyright © Сюткин В.Е., Андрейцева О.И., Никулина В.П., Чугунов А.О., 20182018Сюткин В.Е., Андрейцева О.И., Никулина В.П., Чугунов А.О.Syutkin V.E., Andreytseva O.I., Nikulina V.P., Chugunov A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/373

Проанализированы эффективность и безопасность назначения эверолимуса 10 реципиентам печени в посттрансплантационном периоде с одновременным снижением дозы ингибиторов кальциневрина. После конверсии иммуносупрессии длительность наблюдения за пациентами составила от 4 до 18 мес. Эпизодов острого клеточного отторжения не наблюдалось. Уже в первый месяц после включения эверолимуса в схему иммуносупрессивной терапии наблюдалось улучшение показателей функции почек, которое сохранялось при последующем наблюдении за больными. Серьезных нежелательных явлений не отмечено.

The efficacy and safety of everolimus in 10 recipients of liver in the post-transplant period with simultaneous reducing the dose of calcineurin inhibitors are analyzed. After conversion of immunosuppression the duration of monitoring of patients ranged from 4 to 18 months. Episodes of acute cellular rejection were not observed. Already in the first month after inclusion of everolimus in the scheme of immunosuppressive therapy, there was observed an improvement in renal function, which persisted at follow-up of patients. No serious adverse events were observed.

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The authors declare that there are no conflicts of interest present.