References

transplantologiya

Трансплантология

Transplantologiya. The Russian Journal of Transplantation

2074-05062542-0909

IPO Association of Transplantologists

10.23873/2074-0506-2012-0-1-2-20-32

transplantologiya-375

Research Article

ПРОБЛЕМНЫЕ АСПЕКТЫ

PROBLEMATIC ASPECTS

Паракринные механизмы противовоспалительного и органопротективного действия при трансплантации мезенхимальных стволовых клеток. Обзор литературы

Paracrine mechanisms of antiinflammatory and organoprotective effects in MSC transplantation

Хубутия

М. Ш.

Khubutiya

M. Sh.

Вагабов

В. А.

Vagabov

V. A.

Темнов

А. А.

Temnov

A. A.

aa-temnov@yandex.ru

Склифас

А. Н.

Sklifas

A. N.

НИИ Скорой помощи им. Н.В. СклифосовскогоРоссияSklifosovsky Research Institute for Emergency MedicineRussian Federation

ИБК РАНРоссияInstitute of cell biophysicsRussian Federation

2012

24082018

01-22032

2018

Хубутия М.Ш., Вагабов В.А., Темнов А.А., Склифас А.Н.

Khubutiya M.S., Vagabov V.A., Temnov A.A., Sklifas A.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.jtransplantologiya.ru/jour/article/view/375

Обобщены и систематизированы многие исследований и наблюдений о паракринных факторах, выделяемых стволовыми клетками, и об их биологической функции. Дана краткая характеристика основных групп цитокинов.

The purpose of this review was to systematize data of many studies and observations of paracrine factors of MSC and their biological effects. Also a brief description of main groups of cytokins was revealed in the review.

стволовые клеткицитокиныпаракринный эффект

stem cellcytokinesparacrine effect

References1

Ярилин, А.А. Основы иммунологии / А.А. Ярилин. – М.: Медицина, 1999. – 608 с.

Ройт, А. Иммунология / А. Ройт, Дж. Бростофф, Д. Мейл. – М. : Мир, 2000. – 592 с.

Heron, M. Deaths: leading causes for 2004 / M. Heron // Natl. Vital. Stat. Rep. 2007. – Vol. 56 (5). – P. 1–95.

Bone Marrow Mesenchymal Stromal Cells Attenuate Organ Injury Induced by LPS and Burn / H. Yagi [et al.] // Cell Transplant. – 2010. – Vol. 19 (6). – P. 823–830.

Life-Sparing Effect of Human Cord Blood-Mesenchymal Stem Cells in Experimental Acute Kidney / M. Morigi [et al.] // STEM CELLS. – 2010. – Vol. 28 (3). – P. 513–522.

Human Bone Marrow Mesenchymal Stem Cells Accelerate Recovery of Acute Renal Injury and Prolong Survival in Mice / M. Morigi [et al.] // STEM CELLS. – 2008. – 26 (8). – P. 2075–2082.

Growth factor and cytokine expression of human mesenchymal stromal cells is not altered in an in vitro model of tissue damage / K. Montzka // Cytotherapy. – 2010. – Vol. 12 (7). – P. 870–880.

Allogenic human mesenchymal stem cells for treatment of E. coli endotoxininduced acute lung injury in the ex vivo perfused human lung / W. Lee [et al.] // PNAS. – 2009. – Vol. 106(38). – P. 16357– 16362.

Human marrow-derived mesenchymal stromal cells decrease cisplatin renotoxicity in vitro and in vivo and enhance survival of mice post-intraperitoneal injection / N. Eliopoulos [et al.] // AJP – Renal Physiol. – 2010. – Vol. 299 (6). – P. 1288–1298.

Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-ainduced protein 6 / S. Danchuk [et al.] // Stem Cell Research Therapy. – 2011. – Vol. 2 (3). – P. 27.

Reactive Bone Marrow Stromal Cells Attenuate Systemic Inflammation via sTNFR1 / H. Yagi [et al.] // Molecular Therapy. – 2010. – Vol. 18 (10). – P. 1857–1864.

Stromal Cells Protect against Acute Tubular Injury via an Endocrine Effect / B. Bi [et al.] // J. Am. Soc. Nephrol. – 2007. – Vol. 18 (9). – P. 2486 –2496.

Mesenchymal Stem Cells Enhance Wound Healing Through Differentiation and Angiogenesis / Y. Wu [et al.] // Stem Cells. – 2007. – Vol. 25 (10). – P. 2648– 2659.

Gender Differences In Injury Induced Mesenchymal Stem Cell Apoptosis and VEGF, TNF, IL-6 expression: Role of the 55 kDA TNF Receptor (TNFR1) / P.R. Crisostomo [et al.] // J. Mol. Cell Cardiol. – 2007. – Vol. 42 (1). – P. 142–149.

Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer / T. Asahara [et al.] // Circulation. – 1996. – Vol. 94 (12). – P. 3291–3302.

Vascular endothelial growth factor induces branching morphogenesis tubulogenesis in renal epithelial cells in a neuropilin-dependent fashion / A. Karihaloo [et al.] // Mol. Cell Biol. – 2005. – Vol. 25 (17). – P. 7441–7448.

Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats / S.B. Miller [et al.] // Am. J. Physiol. 1994. – Vol. 266 (1Pt2). – P. 129–134.

Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat / S.B. Miller [et al.] // Proc. Natl. Acad. Sci. USA. – 1992. – Vol. 89 (24). – P. 11876–11880.

The phosphoinositide-3 kinase gamma-Akt pathway mediates renal 2008, 73(4). tubular injury in cisplatin nephrotoxicity / H. Kuwana [et al.] // Kidney Int. – P. 430–445.

Lieberthal, W. Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: Apoptosis vs necrosis / W. Lieberthal, V. Triaca, J. Levine // Am. J. Physiol. – 1996. – Vol. 270 (4Pt2). – P. 700–708.

Low doses of insulinlike growth factor I improve insulin resistance, lipid metabolism, and oxidative damage in aging rats / M. Garcia-Fernandez [et al.] // Endocrinology. – 2008. – Vol. 149 (5). – P. 2433–2442.

Hepatocyte growth factor protects small airway epithelial cells from apoptosis induced by tumor necrosis factoralpha or oxidative stress / M. Okada [et al.] // Pediatr. Res. – 2004. – Vol. 56 (3). – P. 336–344.

Kumar, P. MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway / P. Kumar, A.L. Miller, P.J. Polverini // Biol. Chem. – 2004. – Vol. 279 (41). – P. 43352–43360.

Angiogenic effects of human multipotent stromal cell conditioned medium activate the P13K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis / S.C. Hung [et al.] // Stem Cells. – 2007. – Vol. 25 (9). – P. 2363– 2370.

Ramesh, G. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity / G. Ramesh, W.B. Reeves // J. Clin. Invest. – 2002. – Vol. 110. – P. 835–842.

Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells / B. Zhang [et al.] // Kidney Int. – 2007. – Vol. 72 (1). – P. 37–44.

The link module from ovulationand inflammation-associated protein TSG-6 changes conformation on hyaluronan binding / C.D. Blundell [et al.] // J. Biol. Chem. – 2003. – Vol. 278 (49). – P. 49261–49270.

Milner, C.M. TSG-6: a pluripotent inflammatory mediator? / C.M. Milner, V.A. Higman // Biochem. Soc. Trans. – 2006. – Vol. 34 (Pt3). – P. 446–450.

Wisniewski, H.G. // Cytokineinduced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14 / H.G. Wisniewski, J. Vilcek // Cytokine Growth Factor Rev. – 2004. – Vol. 15 (2–3). – P. 129–146.

Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells / J.Y. Oh [et al.] // Cytokine. – 2009. – Vol. 46 (1). – P. 100–103.

Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells / B. Parekkadan [et al.] // Biochem Biophys. Res. Commun. – 2007. – Vol. 363 (2). – P. 247–252.

Aggarwal, S. Human mesenchymal stem cells modulate allogeneic immune cell responses / S. Aggarwal, M.F. Pittenger // Blood. – 2005. – Vol. 105 (4). – P. 1815–1822.

Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production / K. Nemeth [et al.] // Nat. Med. – 2009 . – Vol. 15 (1). – P. 42–49.

Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells / M.E. Groh [et al.] // Exp. Hematol. – 2005. – Vol. 33 (8). – P. 928–934.

Aggarwal, S. Human mesenchymal stem cells modulate allogeneic immune cell responses / S. Aggarwal, M.F. Pittenger // Blood. – 2005. – Vol. 105 (4). – P. 1815–1822.

Interactions between human mesenchymal stem cells and natural killer cells / P.A. Sotiropoulou [et al.] // Stem Cells. – 2006. – Vol. 24 (1). – P. 74–85.

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts / H.V. Leskela [et al.] // Bone. – 2006. – Vol. 39 (5). – P. 1026–1034.

Temporal expression of estrogen receptor alpha in rat bone marrow mesenchymal stem cells / Q. Wang [et al.] // Biochem Biophys. Res. Commun. – 2006. – Vol. 347 (1). – P. 117–23.

Han, H.J. Estradiol-17beta stimulates proliferation of mouse embryonic stem cells: involvement of MAPKs and CDKs as well as protooncogenes / H.J. Han, J.S. Heo, Y.J. Lee // Am. J. Physiol. Cell Physiol. – 2006. – Vol. 290 (4). – P. 1067– 1075.

Симбирцев, А.С. Перспективы применения препаратов цитокинов в дерматовенерологии / А.С. Симбирцев // Практическая медицина. – 2011. – № 49. – С. 15–22.

Хаитов, Р.М. Иммунология / Р.М. Хаитов, Г.А. Игнатьева, И.Г. Сидорович. – М. : Медицина, 2000. – 432 с.

Autologues bone marrow transplantation in patients with subcute and chronic spinal cord injury / E. Sykova [et al.] // Cell. Transplant. – 2006. – Vol. 15 (8–9). – P. 675–687.

Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte – macrophage colony stimulating factor / H.C. Park [et al.] // Tissue Eng. – 2005. – Vol. 11 (5–6). – P. 913–922.

Figure 15-60: BAD phosphorylation by Akt. Molecular biology of the cell / B. Alberts. – New York : Garland Science, 2002.

Низкомолекулярные пептидные препараты, полученные из культивированных стволовых клеток, при лечении острой почечной недостаточности / М.Ш. Хубутия [и др.] // Трансплантология. – 2011. –№ 4. – С. 20–25

The authors declare that there are no conflicts of interest present.