transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2019-11-4-320-329transplantologiya-464Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESТяжелое течение инфекции Clostridium diffi cile после трансплантации печени и почкиSevere Clostridium diffi cile infection after liver and kidney transplantationhttps://orcid.org/0000-0003-4864-1483КокинаК. Ю.KokinaK. Yu.

Ксения Юрьевна Кокина старший научный сотрудник, врач-гастроэнтеролог отделения трансплантации и хирургии печени

129110, Россия, Москва, ул. Щепкина, д. 61/2

Kseniya Yu. Kokina Senior Researcher, Gastroenterologist, Department of Liver Transplantation and Surgery

61/2 Shchepkin St., Moscow, 129110

kseniaur@yandex.ruhttps://orcid.org/0000-0003-4580-278XМалиновскаяЮ. О.MalinovskayaYu. O.

Юлия Олеговна Малиновская научный сотрудник, врач-гастроэнтеролог отделения трансплантации и хирургии печени

129110, Россия, Москва, ул. Щепкина, д. 61/2

Yuliya O. Malinovskaya Research Associate, Gastroenterologist, Department of Liver Transplantation and Surgery

61/2 Shchepkin St., Moscow, 129110

https://orcid.org/0000-0003-2019-7878СидоренкоА. Б.SidorenkoA. B.

Алексей Борисович Сидоренко младший научный сотрудник, врач-хирург отделения трансплантации и хирургии печени

129110, Россия, Москва, ул. Щепкина, д. 61/2

Aleksey B. Sidorenko Junior Researcher, Surgeon, Department of Liver Transplantation and Surgery

61/2 Shchepkin St., Moscow, 129110

https://orcid.org/0000-0002-0002-9183МойсюкЯ. Г.MoisyukYa. G.

Ян Геннадиевич Мойсюк проф., д-р мед. наук, руководитель отдела трансплантологии

129110, Россия, Москва, ул. Щепкина, д. 61/2

Yan G. Moisyuk Prof., Dr. Med. Sci., Head of the Department of Transplantology

61/2 Shchepkin St., Moscow, 129110

ГБУЗ МО МОНИКИ им. М.Ф. ВладимирскогоРоссияMoscow Regional Research and Clinical Institute n.a. M.F. VladimirskiyRussian Federation201912122019114320329Copyright © Кокина К.Ю., Малиновская Ю.О., Сидоренко А.Б., Мойсюк Я.Г., 20192019Кокина К.Ю., Малиновская Ю.О., Сидоренко А.Б., Мойсюк Я.Г.Kokina K.Y., Malinovskaya Y.O., Sidorenko A.B., Moisyuk Y.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/464

В последние годы статистические данные демонстрируют угрожающие темпы роста заболеваемости и смертности от Clostridium difficile-инфекции во всем мире. Данная проблема преимущественно характерна для пациентов хирургического профиля и ассоциирована с проведением антибактериальной терапии и длительным пребыванием в стационаре. К группе риска развития тяжелых форм инфекции C. difficile относятся реципиенты солидных органов в связи с иммуносупрессией. Существующие рекомендации по лечению C. difficile-инфекции основываются на тяжести заболевания и не учитывают особенностей состояния пациентов после трансплантации печени. Целью данной работы является определение актуальной тактики в диагностике и лечении C. difficile у реципиентов для применения в клинической практике.

Recent statistics have shown increased rates of morbidity and mortality from Clostridium difficile infection worldwide. This problem is mainly typical for surgical patients and is associated with an antibiotic therapy and a prolonged hospital stay. Recipients of solid organs are at a high risk of developing severe forms of C. difficile infection due to immunosupression. Existing recommendations for the treatment of C. difficile infection are based on the severity of the disease and do not consider patients after liver transplantation. The aim of this work is to determine an actual tactics for the diagnosis and treatment of C. difficile in organ recipients in clinical practice.

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The authors declare that there are no conflicts of interest present.