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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transplantologiya</journal-id><journal-title-group><journal-title xml:lang="ru">Трансплантология</journal-title><trans-title-group xml:lang="en"><trans-title>Transplantologiya. The Russian Journal of Transplantation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-0506</issn><issn pub-type="epub">2542-0909</issn><publisher><publisher-name>IPO Association of Transplantologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23873/2074-0506-2021-13-4-356-366</article-id><article-id custom-type="elpub" pub-id-type="custom">transplantologiya-612</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ТРАНСПЛАНТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL ISSUES OF TRANSPLANTATION</subject></subj-group></article-categories><title-group><article-title>Влияние поздней дисфункции трансплантата печени на физическую активность реципиентов</article-title><trans-title-group xml:lang="en"><trans-title>The impact of late liver allograft dysfunction on physical activity of liver transplant recipients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4580-278X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малиновская</surname><given-names>Ю. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Malinovskaya</surname><given-names>Yu. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юлия Олеговна Малиновская, научный сотрудник отдела трансплантологии</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Yulia O. Malinovskaya, Research Associate of Transplantology Department</p><p>61/2 Shchepkin St., Moscow 129110</p></bio><email xlink:type="simple">yumalinovskaya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4864-1483</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кокина</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kokina</surname><given-names>K. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ксения Юрьевна Кокина,  канд. мед. наук, старший научный сотрудник отдела трансплантологии </p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Ksenia Yu. Kokina, Cand. Sci. (Med.), Senior Researcher of Transplantology Department</p><p>61/2 Shchepkin St., Moscow 129110</p></bio><email xlink:type="simple">kseniaur@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0002-9183</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мойсюк</surname><given-names>Я. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Moysyuk</surname><given-names>Ya. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ян Геннадиевич Мойсюк, проф., д-р мед. наук, заведующий отделом трансплантологии</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Yan G. Moysyuk, Prof., Dr. Sci. (Med.), Head of the Department of Transplantology</p><p>61/2 Shchepkin St., Moscow 129110</p></bio><email xlink:type="simple">moysyuktrans@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3440-6685</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сумцова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sumtsova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Васильевна Сумцова, научный сотрудник отдела трансплантологии</p><p>129110, Москва, ул. Щепкина, д. 61/2</p></bio><bio xml:lang="en"><p>Olga V. Sumtsova, Research Associate of Transplantology Department</p><p>61/2 Shchepkin St., Moscow 129110</p></bio><email xlink:type="simple">ovmoniki@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО МОНИКИ им. М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>15</day><month>12</month><year>2021</year></pub-date><volume>13</volume><issue>4</issue><fpage>356</fpage><lpage>366</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Малиновская Ю.О., Кокина К.Ю., Мойсюк Я.Г., Сумцова О.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Малиновская Ю.О., Кокина К.Ю., Мойсюк Я.Г., Сумцова О.В.</copyright-holder><copyright-holder xml:lang="en">Malinovskaya Y.O., Kokina K.Y., Moysyuk Y.G., Sumtsova O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jtransplantologiya.ru/jour/article/view/612">https://www.jtransplantologiya.ru/jour/article/view/612</self-uri><abstract><sec><title>Введение</title><p>Введение. Трансплантация печени позволяет вернуть пациенту привычную физическую и социальную активность и обеспечить высокое качество жизни. Однако распространенность среди реципиентов печени гиподинамии и влияние на нее поздней дисфункции трансплантата, являющейся фактором риска ожирения и сердечно-сосудистых заболеваний, требует изучения.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: выявление влияния поздней дисфункции трансплантата на физическую активность реципиентов печени.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены 87 пациентов, перенесших трансплантацию печени, которым измеряли антропометрические параметры, определяли физическую выносливость (SPPB, LFI, тест 6-минутной ходьбы), физическую активность (среднее количество шагов в день) и обследовали на предмет дисфункции трансплантата. Поздняя дисфункция трансплантата печени определялась в случае нарушения функции трансплантата, проявляющегося синдромами цитолиза, холестаза или печеночно-клеточной недостаточности в срок более 3 месяцев после трансплантации. Для изучения физической активности выдавали трекер активности.</p></sec><sec><title>Результаты</title><p>Результаты. Медиана возраста составила 54 года [45;61], 33% – мужчины. Медиана срока наблюдения после трансплантации печени – 36 месяцев [16;64]. Медиана количества шагов составила 5,9 [4,1;8,7] тысячи в сутки. Доля реципиентов, ведущих сидячий и малоактивный образ жизни, составила 60,5%, среднеактивных – 24,4%, активных – 15,1%. У реципиентов с поздней дисфункцией трансплантата печени среднее количество шагов в день оказалось статистически значимо меньше, чем у пациентов с нормальной функцией: 4,1 [2,6;5,3] тысячи и 6,8 [4,2;9,4] тысячи соответственно, p=0,003, несмотря на отсутствие различий по результатам тестов физической выносливости.</p></sec><sec><title>Заключение</title><p>Заключение. Поздняя дисфункция трансплантата печени приводит к снижению физической активности, что является дополнительным фактором риска уменьшения продолжительности жизни реципиентов. Несмотря на отсутствие патологического ограничения движения, 60,5% реципиентов печени ведет малоподвижный образ жизни. Трекеры активности, являясь объективным методом регистрации состояния реципиента, могут способствовать выявлению реципиентов, нуждающихся в дополнительном обследовании и/или включении в программы физической реабилитации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Liver transplantation restores patients' physical and social life, and its quality. The prevalence of low physical activity in liver recipients is unknown as well as the impact of late liver allograft dysfunction on it. Liver transplantation enhances patient's return to the usual physical and social activity and improves the quality of life. However, the prevalence of low physical activity among liver recipients and the impact of the late allograft dysfunction on it, which is a risk factor for obesity and cardiovascular diseases, require studying.</p><p>The aim of the study was to identify whether the late liver allograft dysfunction influences the physical activity of recipients.</p></sec><sec><title>Material and methods</title><p>Material and methods. The study included 87 liver recipients. We measured anthropometric parameters, physical performance (SPPB, LFI, 6-min walk test), mean step count per day. Late liver allograft dysfunction was determined if elevated transaminases and/or cholestatic enzymes or hepatic failure have been diagnosed later than 3 months posttransplant. Activity trackers were provided to assess physical activity.</p></sec><sec><title>Results</title><p>Results. Median age was 54 years [45;61], 33% were men. The median follow-up period was 36 months [16;64]. The median of the average steps count was 5.9 [4.1;8.7] thousand per day. 60.5% of recipients were sedentary and low active, 24.4% were somewhat active, 15.1% were active. In cases of liver allograft dysfunction, the mean step count was significantly lower than in patients with normal liver function: 4.1 thousand [2.6;5.3] versus 6.8 thousand [4.2;9.4], p=0.003, despite no differences in the physical activity test results.</p></sec><sec><title>Conclusion</title><p>Conclusion. In case of a late liver allograft dysfunction, the physical activity can decrease; 60.5% of liver recipients, in the absence of pathological restriction of movement, have a sedentary and low active lifestyle. Activity trackers may allow identifying patients who need additional check-up or physical training.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трекер активности</kwd><kwd>носимое устройство</kwd><kwd>трансплантация печени</kwd><kwd>ожирение</kwd><kwd>гиподинамия</kwd><kwd>реципиент печени</kwd><kwd>отдаленные результаты трансплантации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>activity tracker</kwd><kwd>wearable device</kwd><kwd>liver transplantation</kwd><kwd>obesity</kwd><kwd>sedentary lifestyle</kwd><kwd>liver recipient</kwd><kwd>long term transplant follow-up</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kwong A, Kim WR, Lake JR, Smith JM, Schladt DP, Skeans MA, et al. OPTN/SRTR 2018 Annual data report: liver. Am J Transplant. 2020;20(Suppl s1):193–299. 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