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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transplantologiya</journal-id><journal-title-group><journal-title xml:lang="ru">Трансплантология</journal-title><trans-title-group xml:lang="en"><trans-title>Transplantologiya. The Russian Journal of Transplantation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-0506</issn><issn pub-type="epub">2542-0909</issn><publisher><publisher-name>IPO Association of Transplantologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23873/2074-0506-2022-14-1-10-19</article-id><article-id custom-type="elpub" pub-id-type="custom">transplantologiya-626</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ ВОПРОСЫ ТРАНСПЛАНТОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL ISSUES OF TRANSPLANTATION</subject></subj-group></article-categories><title-group><article-title>Отрицательная динамика индекса резистентности печеночной артерии как предиктор развития раннего тромбоза после трансплантации печени от посмертного донора</article-title><trans-title-group xml:lang="en"><trans-title>Negative dynamics of the hepatic artery resistive index as a predictor of early arterial thrombosis after deceased donor liver transplantation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0522-0681</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шабунин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shabunin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Васильевич Шабунин, чл.-корр. РАН, проф., д-р мед. наук, главный врач; заведующий кафедрой хирургии</p><p>125284, Москва, 2-й Боткинский пр-д, д. 5125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Aleksey V. Shabunin, Corresponding Member of the Russian Academy of Sciences, Prof., Dr. Sci. (Med.), Head Physician; Head of the Department of Surgery</p><p>5 2nd Botkinskiy Dr., Moscow 1252842/1 Bldg. 1 Barrikadnaya St., Moscow 125993</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8016-1610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дроздов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Drozdov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павел Алексеевич Дроздов, канд. мед. наук, заведующий отделением трансплантации органов и/или тканей человека</p><p>125284, Москва, 2-й Боткинский пр-д, д. 5</p></bio><bio xml:lang="en"><p>Pavel A. Drozdov, Cand. Sci. (Med.), Head of the Department of Organ and/or Tissue Transplantation</p><p>5 2nd Botkinskiy Dr., Moscow 125284</p></bio><email xlink:type="simple">dc.drozdov@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5814-4504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Левина</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Levina</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оксана Николаевна Левина, канд. мед. наук, заведующий отделением гастрогепатопанкреатоэнтерологии</p><p>125284, Москва, 2-й Боткинский пр-д, д. 5</p></bio><bio xml:lang="en"><p>Oksana N. Levina, Cand. Sci. (Med.), Head of the Department of Gastrohepatopancreatoenterology</p><p>5 2nd Botkinskiy Dr., Moscow 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5237-4387</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макеев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Makeev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Александрович Макеев, канд. мед. наук, врач-хирург отделения трансплантации органов и/или тканей</p><p>125284, Москва, 2-й Боткинский пр-д, д. 5</p></bio><bio xml:lang="en"><p>Dmitriy A. Makeev, Cand. Sci. (Med.), Surgeon, Department of Organ and/or Tissue Transplantation</p><p>5 2nd Botkinskiy Dr., Moscow 125284</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8225-0024</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавель</surname><given-names>О. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravel</surname><given-names>O. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олеся Сергеевна Журавель, врач-хирург; старший лаборант кафедры хирургии</p><p>125284, Москва, 2-й Боткинский пр-д, д. 5125993, Москва, ул. Баррикадная, д. 2/1, стр. 1</p></bio><bio xml:lang="en"><p>Olesya S. Zhuravel, Surgeon; Senior Laboratory Assistant of Surgery Department</p><p>5 2nd Botkinskiy Dr., Moscow 1252842/1 Bldg. 1 Barrikadnaya St., Moscow 125993</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9794-0696</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Астапович</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Astapovich</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евгения Юрьевна Астапович, студент лечебного факультета</p><p>117997, Москва, ул. Островитянова, д. 1</p></bio><bio xml:lang="en"><p>Evgeniya Yu. Astapovich, Medical Student</p><p>1 Ostrovityanov St., Moscow 117997</p></bio><email xlink:type="simple">sneg.svoboda18@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ ГКБ им. С.П. Боткина ДЗМ; ФГБОУ ДПО РМАНПО МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital n.a. S.P. Botkin; Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ ГКБ им. С.П. Боткина ДЗМ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital n.a. S.P. Botkin</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University (Pirogov Medical University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>16</day><month>03</month><year>2022</year></pub-date><volume>14</volume><issue>1</issue><fpage>10</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шабунин А.В., Дроздов П.А., Левина О.Н., Макеев Д.А., Журавель О.С., Астапович Е.Ю., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Шабунин А.В., Дроздов П.А., Левина О.Н., Макеев Д.А., Журавель О.С., Астапович Е.Ю.</copyright-holder><copyright-holder xml:lang="en">Shabunin A.V., Drozdov P.A., Levina O.N., Makeev D.A., Zhuravel O.S., Astapovich E.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jtransplantologiya.ru/jour/article/view/626">https://www.jtransplantologiya.ru/jour/article/view/626</self-uri><abstract><p>Цель. Оценить достоверность отрицательной динамики индекса резистентности печеночной артерии в качестве предиктора раннего тромбоза у реципиентов печеночного трансплантата от посмертного донора, определить факторы риска и выделить группу пациентов с повышенным риском данного осложнения.Материал и методы. С июля 2018 года по август 2021 года в хирургической клинике ГКБ им. С.П. Боткина выполнены 92 ортотопические трансплантации печени от посмертного донора. Все печеночные трансплантаты были взяты от доноров с констатированной смертью головного мозга. Контрольное ультразвуковое допплеровское исследование печеночных кровотоков у всех больных проводилось на 1-е, 3-и, 5-е, 7-е сутки, при необходимости – ежедневно. Индекс резистентности в артериях печеночного трансплантата считали нормальным при показателях от 0,55 до 0,79, высоким – от 0,8 до 0,89, крайне высоким – при значениях выше 0,9. В зависимости от показателя индекса резистентности в 1-е послеоперационные сутки и динамики его изменения в последующем мы разделили пациентов на три группы. В каждой группе мы проанализировали частоту тромбоза печеночной артерии и оценили влияние различных факторов риска на повышение индекса резистентности в 1-е сутки после операции и на его рост при динамическом наблюдении в раннем послеоперационном периоде.Результаты. Из 92 трансплантаций печени в трех случаях нами зафиксирован тромбоз печеночной артерии (3,2%), не связанный с техническими трудностями артериальной реконструкции. Во всех трех случаях смертельных исходов не отмечено. У пациентов с нормальным или высоким индексом резистентности в 1-е сутки, без его нарастания при динамическом наблюдении, частота артериального тромбоза составила 0%. У пациентов с нормальным или высоким индексом резистентности на 1-е сутки и его нарастанием при динамическом наблюдении, а также у пациентов с крайне высоким индексом резистентности в 1-е сутки частота артериального тромбоза составила 18,1% и 11,1% соответственно. Факторами риска для крайне высокого индекса резистентности в 1-е послеоперационные сутки стали возраст реципиента старше 50 лет (р=0,024), а для роста индекса резистентности при динамическом наблюдении – возраст донора старше 50 лет (р=0,04).Заключение. Отсутствие положительной динамики в снижении индекса резистентности в печеночной артерии может быть дополнительным предиктором артериального тромбоза после трансплантации печени. Этот факт позволяет выделить группу высокого риска развития артериального тромбоза, провести у этих пациентов дополнительные профилактические мероприятия и улучшить непосредственные результаты лечения данной группы больных.</p></abstract><trans-abstract xml:lang="en"><p>Aim. The study aim was to assess the negative dynamics of the hepatic artery resistive index as a reliable predictor of early thrombosis in liver transplant recipients from a postmortem donor, to determine risk factors and to identify a group of patients with an increased risk of this complication.Material and methods. From July 2018 to August 2021, 92 orthotopic liver transplants from a deceased donor were performed at the Surgical Clinic of the City Clinical Hospital n.a. S.P. Botkin. All liver grafts were taken from donors with brain death. Control Doppler ultrasound examination of hepatic blood flow in all patients was performed on days 1, 3, 5, 7, if necessary, daily. The hepatic arteries resistive index was considered normal at values from 0.55-0.79, high at 0.8-0.89, extremely high above 0.9. Depending on the resistive index value on the 1st postoperative day and its further dynamics, we divided the patients into 3 groups. In each group, we analyzed the incidence of hepatic artery thrombosis and assessed the impact of various risk factors on the resistive index elevation on the 1st day after surgery and on its growth during dynamic observation in the early postoperative period.Results. Of 92 liver transplants, in three cases, we recorded hepatic artery thrombosis (3.2%), which was not associated with technical difficulties of arterial reconstruction. No mortality was recorded in all three cases. In patients with a normal or high resistive index on the 1st day, without its increase during dynamic observation, the incidence of arterial thrombosis was 0%. In patients with a normal or high resistive index on the 1st day, and its increase during dynamic observation, as well as in patients with an extremely high resistive index on the 1st day, the incidence of arterial thrombosis was 18.1% and 11.1%, respectively. The risk factors of thrombosis were the age of the recipient over 50 years old in an extremely high resistive index on the 1st postoperative day (p=0.024), and the age of the donor over 50 years old in the growth of the resistive index during follow-up (p=0.04).Conclusion. The lack of positive dynamics in the hepatic artery resistive index reduction may be an additional predictor of arterial thrombosis after liver transplantation. This fact makes it possible to identify a high-risk group of arterial thrombosis, to take additional preventive measures in these patients and to improve the immediate results of treatment in this group of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>трансплантация печени</kwd><kwd>тромбоз печеночной артерии</kwd><kwd>индекс резистентности</kwd></kwd-group><kwd-group xml:lang="en"><kwd>liver transplantation</kwd><kwd>hepatic artery thrombosis</kwd><kwd>resistive index</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bekker J, Ploem S, de Jong KP. Early hepatic artery thrombosis after liver transplantation: a systematic review of the incidence, outcome and risk factors. Am J of Transplant. 2009;9(4):746–757. PMID: 19298450 http://doi.org/10.1111/j.1600-6143.2008.02541.x</mixed-citation><mixed-citation xml:lang="en">Bekker J, Ploem S, de Jong KP. 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PMID: 29142490 https://doi.org/10.1055/s-0037-1598623</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
