transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2022-14-3-344-356transplantologiya-690Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESДоступные способы повышения регенераторного потенциала пластического материала в неотложной травматологии. Часть 3. Применение аутологичного красного костного мозга человекаAvailable methods to enhance regenerative potential of plastic materials for bone defects replacement in orthopedics. Part 3. Use of autologous human red bone marrowhttps://orcid.org/0000-0001-8616-920XФайнА. М.FainA. M.

Алексей Максимович Файн, д-р мед. наук, заведующий научным отделением неотложной травматологии опорно-двигательного аппарата; профессор кафедры травматологии, ортопедии и медицины катастроф

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

 127473, Россия, Москва, Делегатская ул., д. 20, стр. 1 

Aleksey M. Fayn, Dr. Sci. (Med.), Head of the Scientific Department of Emergency Traumatology of the Musculoskeletal System; Professor of the Department of Traumatology, Orthopedics, and Disaster Medicine

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

 20 Bldg. 1 Delegatskaya St., Moscow 127473 Russia 

FainAM@sklif.mos.ruhttps://orcid.org/0000-0003-4581-449XВазаА. Ю.VazaA. Yu.

Александр Юльевич Ваза, канд. мед. наук, ведущий научный сотрудник отделения неотложной травматологии опорно-двигательного аппарата 

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

 Aleksandr Yu. Vaza, Cand. Sci. (Med.), Leading Researcher, Department of Emergency Traumatology of the Musculoskeletal System

  3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

VazaAU@sklif.mos.ruhttps://orcid.org/0000-0001-9932-1653ГнетецкийС. Ф.GnetetskiyS. F.

Сергей Феликсович Гнетецкий, д-р мед. наук, ведущий научный сотрудник отделения неотложной травматологии опорно-двигательного аппарата; доцент кафедры травматологии, ортопедии и медицины катастроф 

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

 127473, Россия, Москва, Делегатская ул., д. 20, стр. 1 

Sergey F. Gnetetskiy, Dr. Sci. (Med.), Leading Researcher, Department of Emergency Traumatology of the Musculoskeletal System; Associate Professor of the Department of Traumatology, Orthopedics, and Disaster Medicine

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

 20 Bldg. 1 Delegatskaya St., Moscow 127473 Russia 

GnetetskiySF@sklif.mos.ruСкуратовскаяК. И.SkuratovskayaK. I.

Кристина Ивановна Скуратовская, младший научный сотрудникотделения неотложной травматологии опорно-двигательного аппарата   

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

Kristina I. Skuratovskaya, Junior Researcher, Department of Emergency Traumatology of the Musculoskeletal System 

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

SkuratovskayaKI@sklif.mos.ruhttps://orcid.org/0000-0002-1183-3644БондаревВ. Б.BondarevV. B.

Василий Бриджевич Бондарев, научный сотрудник отделения неотложной травматологии опорно-двигательного аппарата 

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

Vasiliy B. Bondarev, Researcher, Department of Emergency Traumatology of the Musculoskeletal System 

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

BondarevVB@sklif.mos.ruhttps://orcid.org/0000-0002-1509-7082БоголюбскийЮ. А.BogolyubskiyYu. A.

Юрий Андреевич Боголюбский, канд. мед. наук, научный сотрудник отделения неотложной травматологии опорно-двигательного аппарата 

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

Yuriy A. Bogolyubskiy, Cand. Sci. (Med.), Researcher, Department of Emergency Traumatology of the Musculoskeletal System 

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

BogoljubskijUA@sklif.mos.ruhttps://orcid.org/0000-0002-2960-8736ТитовР. С.TitovR. S.

Роман Сергеевич Титов, канд. мед. наук, старший научный сотрудник отделения неотложной травматологии опорно-двигательного аппарата 

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

Roman S. Titov, Cand. Sci. (Med.), Senior Researcher, Department of Emergency Traumatology of the Musculoskeletal System 

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

TitovRS@sklif.mos.ruhttps://orcid.org/0000-0001-9574-398XСергеевА. Ю.SergeevA. Yu.

Александр Юрьевич Сергеев, научный сотрудник отделения неотложной травматологии опорно-двигательного аппарата

 129090, Россия, Москва, Большая Сухаревская пл., д. 3 

Aleksandr Yu. Sergeev, Researcher, Department of Emergency Traumatology of the Musculoskeletal System 

 3 Bolshaya Sukharevskaya Sq., Moscow 129090 Russia 

SergeevAY@sklif.mos.ruГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра травматологии, ортопедии и медицины катастроф ФГБОУ ВО МГМСУ им. А.И. Евдокимова МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and Dentistry Russian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation202217092022143344356Copyright © Файн А.М., Ваза А.Ю., Гнетецкий С.Ф., Скуратовская К.И., Бондарев В.Б., Боголюбский Ю.А., Титов Р.С., Сергеев А.Ю., 20222022Файн А.М., Ваза А.Ю., Гнетецкий С.Ф., Скуратовская К.И., Бондарев В.Б., Боголюбский Ю.А., Титов Р.С., Сергеев А.Ю.Fain A.M., Vaza A.Y., Gnetetskiy S.F., Skuratovskaya K.I., Bondarev V.B., Bogolyubskiy Y.A., Titov R.S., Sergeev A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/690

В предыдущих двух статьях было описано про применение богатой тромбоцитами плазмы и тромбоцитарного лизата. В данной части литературного обзора рассматривается механизм действия красного костного мозга, показания и противопоказания к его применению, описаны результаты лечения при нарушении консолидации переломов костей. Гемопоэтические стволовые клетки дают начало всем клеточным компонентам циркулирующей крови, таким как эритроциты, лимфоциты, нейтрофилы и тромбоциты. Наиболее рациональным для стимуляции костной регенерации является использование собственного биологического материала пациента. Целью данной статьи является обобщение результатов лечения с использованием аутологичного красного костного мозга для улучшения регенераторного потенциала в травматологии.

The previous two articles described the use of platelet-rich plasma and platelet lysate. This part of the literature review examines the mechanism of red bone marrow action, indications and contraindications for its use. The results of treatment for delayed consolidation of bone fractures are also described. Hematopoietic stem cells give rise to all cellular components of the circulating blood, such as red blood cells, lymphocytes, neutrophils, and platelets. The most rational way to stimulate bone regeneration is to use the patient's own biological material. The aim of this article is to summarize the results of treatment using autologus bone marrow to improve bone regenerative potential in orthopaedics.

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The authors declare that there are no conflicts of interest present.