transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2022-14-4-488-499transplantologiya-710Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESМониторинг химеризма после трансплантации аллогенных гемопоэтических стволовых клетокMonitoring of chimerism after allogeneic hematopoietic stem cell transplantationhttps://orcid.org/0000-0002-2253-9870ДубнякД. С.DubnyakD. S.

Дарья Станиславовна Дубняк, врач-гематолог

125167, Москва, Новый Зыковский пр-д, д. 4

Darya S. Dubnyak, Hematologist

4 Noviy Zykovskiy Dr., Moscow 125167

darya-dubnyak@yandex.ruhttps://orcid.org/0000-0003-2957-1619РисинскаяН. В.RisinskayaN. V.

Наталья Владимировна Рисинская, канд. биол. наук, старший научный сотрудник лаборатории молекулярной гематологии

125167, Москва, Новый Зыковский пр-д, д. 4

Natalia V. Risinskaya, Cand. Sci. (Biol.), Senior Researcher, Laboratory of Molecular Hematology

4 Noviy Zykovskiy Dr., Moscow 125167

https://orcid.org/0000-0001-9431-8316ДроковМ. Ю.DrokovM. Yu.

Михаил Юрьевич Дроков, канд. мед. наук, врач-гематолог, руководитель сектора научных исследований химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга

125167, Москва, Новый Зыковский пр-д, д. 4

Cand. Sci. (Med.), Hematologist, Head of the Sector for Scientific Research in Chemoblastosis Chemotherapy, Hematopoietic Depressions, and Bone Marrow Transplantation

4 Noviy Zykovskiy Dr., Moscow 125167

https://orcid.org/0000-0001-9463-9187СудариковА. Б.SudarikovA. B.

Андрей Борисович Судариков, д-р биол. наук, заведующий лабораторией молекулярной гематологии

125167, Москва, Новый Зыковский пр-д, д. 4

Andrey B. Sudarikov, Dr. Sci. (Biol.), Head of the Laboratory of Molecular Hematology

4 Noviy Zykovskiy Dr., Moscow 125167

ФГБУ «НМИЦ гематологии» МЗ РФРоссияNational Medical Research Center for HematologyRussian Federation202221122022144488499Copyright © Дубняк Д.С., Рисинская Н.В., Дроков М.Ю., Судариков А.Б., 20222022Дубняк Д.С., Рисинская Н.В., Дроков М.Ю., Судариков А.Б.Dubnyak D.S., Risinskaya N.V., Drokov M.Y., Sudarikov A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/710

Трансплантация аллогенных гемопоэтических стволовых клеток является одним из эффективных методов лечения пациентов с заболеваниями системы крови.

Среди главных показателей успешной трансплантации в таких случаях является установление полного (100%) донорского химеризма. Мониторинг химеризма позволяет оценить не только приживление трансплантата, но и потенциально спрогнозировать риск развития первичной/вторичной несостоятельности трансплантата, вероятность развития рецидива заболевания и реакции «трансплантат против хозяина».

Задачами данного обзора являются: 1) обобщение основных понятий, связанных с химеризмом после трансплантации аллогенных гемопоэтических стволовых клеток, и 2) рассмотрение вопроса о необходимости исследования химеризма в различных клеточных популяциях, а также взаимосвязи химеризма и развития различных иммунологических осложнений.

Allogeneic hematopoietic stem cells transplantation is one of the effective methods of treating patients with diseases of the blood system.

Establishment of complete (100%) donor chimerism is among of the main indicators of successful transplantation in such cases. Monitoring chimerism makes it possible both to assess the graft acceptance, and also potentially predict the risk of developing primary/secondary graft failure, relapse, and graft-versus-host disease.

The purpose of this review is to summarize the main concepts associated with chimerism after allogeneic hematopoietic stem cell transplantation; consideration of the need to study chimerism in various cell populations, as well as the relationship between chimerism and the development of various immunological complications.

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The authors declare that there are no conflicts of interest present.