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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">transplantologiya</journal-id><journal-title-group><journal-title xml:lang="ru">Трансплантология</journal-title><trans-title-group xml:lang="en"><trans-title>Transplantologiya. The Russian Journal of Transplantation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2074-0506</issn><issn pub-type="epub">2542-0909</issn><publisher><publisher-name>IPO Association of Transplantologists</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.23873/2074-0506-2023-15-1-61-71</article-id><article-id custom-type="elpub" pub-id-type="custom">transplantologiya-745</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CASE REPORTS</subject></subj-group></article-categories><title-group><article-title>Нефролитиаз у родственных доноров почки</article-title><trans-title-group xml:lang="en"><trans-title>Nephrolithiasis in related kidney donors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4415-0903</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перлин</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Perlin</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дмитрий Владиславович Перлин - проф., д-р мед. наук, главный врач </p><p>404120, Россия, Волгоградская область, г. Волжский, ул. им. Генерала Карбышева, д. 86 </p></bio><bio xml:lang="en"><p>Dmitriy V. Perlin - Prof., Dr. Sci. (Med.), Chief Physician </p><p> 86 Karbyshev St., Volgograd region, Volzhsky 404120 Russia </p></bio><email xlink:type="simple">dvperlin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1935-9801</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дымков</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dymkov</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Иван Николаевич Дымков, канд. мед. наук, заместитель главного врача </p><p>404120, Россия, Волгоградская область, г. Волжский, ул. им. Генерала Карбышева, д. 86 </p></bio><bio xml:lang="en"><p>Ivan N. Dymkov - Cand. Sci. (Med.), Deputy Chief Physician</p><p> 86 Karbyshev St., Volgograd region, Volzhsky 404120 Russia </p></bio><email xlink:type="simple">indymkov@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4711-9837</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Терентьев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Terentyev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Вячеславович Терентьев - врач уролог отделения урологии  </p><p>404120, Россия, Волгоградская область, г. Волжский, ул. им. Генерала Карбышева, д. 86 </p></bio><bio xml:lang="en"><p>Aleksey V. Terentyev - Urologist of the Urology Department</p><p> 86 Karbyshev St., Volgograd region, Volzhsky 404120 Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0629-1270</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перлина</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Perlina</surname><given-names>A. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анастасия Дмитриевна Перлина - младший научный сотрудник отделения дерматологии </p><p>129110, Россия, Москва, ул. Щепкина, д. 61/2 </p></bio><bio xml:lang="en"><p>Anastasiya D. Perlina - Junior Researcher of the Dermatology Department</p><p> 61/2 Shchepkin St., Moscow 129110 Russia </p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2628-1640</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александров</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexandrov</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Илья Вячеславович Александров - канд. мед. наук, заместитель главного врача по клинико-экспертной работе </p><p>404120, Россия, Волгоградская область, г. Волжский, ул. им. Генерала Карбышева, д. 86 </p></bio><bio xml:lang="en"><p>Ilya V. Alexandrov - Cand. Sci. (Med.), Deputy Chief Physician</p><p> 86 Karbyshev St., Volgograd region, Volzhsky 404120 Russia </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Волгоградский областной уронефрологический центр»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd Regional Uronephrological Center</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ МО МОНИКИ им. М.Ф. Владимирского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Regional Research and Clinical Institute n.a. M.F. Vladimirskiy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>03</month><year>2023</year></pub-date><volume>15</volume><issue>1</issue><fpage>61</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Перлин Д.В., Дымков И.Н., Терентьев А.В., Перлина А.Д., Александров И.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Перлин Д.В., Дымков И.Н., Терентьев А.В., Перлина А.Д., Александров И.В.</copyright-holder><copyright-holder xml:lang="en">Perlin D.V., Dymkov I.N., Terentyev A.V., Perlina A.D., Alexandrov I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.jtransplantologiya.ru/jour/article/view/745">https://www.jtransplantologiya.ru/jour/article/view/745</self-uri><abstract><p>Введение. Результаты пересадки почки от живых доноров в отдаленном периоде существенно лучше, чем трансплантации от посмертных доноров. Однако в последние годы наблюдается тенденция к снижению доли таких операций. Ситуацию можно улучшить, в том числе, за счет привлечения потенциальных доноров с расширенными критериями. Использование живых доноров с одиночными конкрементами в почке позволило увеличить число трансплантаций в некоторых клиниках.Цель. Оценить собственные результаты использования для трансплантации почки от живых доноров с нефролитиазом и сравнить с литературными данными.Материал и методы. В течение 2012–2021 годов в нашей клинике были выполнены трансплантации почки трем пациентам от родственных доноров с конкрементами в одной почке. Одному донору была предварительно выполнена мини-перкутанная нефролитотрипсия за месяц до нефрэктомии. Двум другим – одномоментная ретроградная нефролитотрипсия и лапароскопическая донорская нефрэктомия. В двух случаях для деструкции конкремента был использован гольмиевый лазер, в одном – тулиевый. Всем донорам была выполнена лапароскопическая ретроперитонеальная нефрэктомия в собственной модификации клиники.Результаты. Конкременты у всех доноров были успешно удалены. Хирургических осложнений на этапе литотрипсии не было отмечено ни у одного донора, как и на последующем этапе удаления почки. Период тепловой ишемии не превышал 3,5 минут. При предварительном удалении конкремента общая продолжительность госпитализации донора составила 10 суток, при одномоментной нефролитотрипсии и нефрэктомии период пребывания в клинике был 6 и 4 суток соответственно. Все пересадки почки выполнены родственным реципиентам. Один из реципиентов до трансплантации получал заместительную терапию гемодиализом, другой – перитонеальным диализом. Третьему реципиенту была выполнена превентивная (додиализная) трансплантация. Функция трансплантата во всех случаях была немедленная. В течение последующего периода наблюдения (9–57 месяцев) признаков нефролитиаза у доноров и реципиентов отмечено не было.Выводы. Привлечение прижизненных доноров с локальным уролитиазом позволяет увеличить число родственных трансплантаций почки. Представленная методика симультанных эндоскопической ретроградной нефролитотрипсии и лапароскопической донорской нефрэктомии является воспроизводимой, эффективной и безопасной. Одновременное выполнение вмешательств позволяет уменьшить продолжительность госпитализации доноров и снизить риск возникновения осложнений по сравнению с последовательными операциями.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Long-term results of renal transplantation from living donors are much better than the results of cadaveric transplantations. Recently, because of the shortage of living donors, some centers have started using kidneys from living donors with asymptomatic stones as a potential solution for the problem. However, the optimal surgical solution for such situations has not yet been developed.Aim. To evaluate our obtained transplantation results of using the kidneys from living donors with nephrolithiasis and compare them with the literature data.Material and methods. In the period from 2012-2021, renal transplantations in our clinic were done in three patients from related donors with stones in the kidney. One donor underwent mini-percutaneous lithotripsy one month prior to nephrectomy. The other two underwent simultaneous retrograde lithotripsy and laparoscopic donor nephrectomy. In these cases a holmium or thulium laser was used for the destruction of calculi. All donors underwent laparoscopic retroperitoneal nephrectomy.Results. All stones were successfully removed. There were no surgical complications in donors during and after procedures. Warm ischemia time did not exceed 3.5 minutes. The general length of hospital stay was 10 days in case of predonation stone removal surgery and 6 and 4 days in the cases of simultaneous procedures, respectively. All grafts were transplanted to related recipients. One of the recipients was treated with hemodialysis before transplantation, the other one with peritoneal dialysis. The third recipient underwent preemptive transplantation (before the start of dialysis). The graft function in all cases was immediate. During the follow-up period (9-57 months), no signs of nephrolithiasis were seen in either donors, or recipients.Conclusions. Consideration of potential donors with stones in one kidney might increase the number of living donor renal transplantation. Simultaneous RIRS and laparoscopic donor nephrectomy can be considered as an alternative to sequential operations or ex vivo stone extraction. The presented technique is reproducible, safe and was not associated with an increased length of hospital stay.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нефролитиаз</kwd><kwd>трансплантация почки</kwd><kwd>лапароскопическая донорская нефрэктомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nephrolithiasis</kwd><kwd>kidney transplantation</kwd><kwd>laparoscopic donor nephrectomy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dols LF, Kok NF, Ijzermans JN. Live donor nephrectomy: a review of evidence for surgical techniques. Transpl Int. 2010;23(2):121–130. PMID: 20003169 https://doi.org/10.1111/j.1432-2277.2009.01027.x</mixed-citation><mixed-citation xml:lang="en">Dols LF, Kok NF, Ijzermans JN. Live donor nephrectomy: a review of evidence for surgical techniques. Transpl Int. 2010;23(2):121–130. 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