References

transplantologiya

Трансплантология

Transplantologiya. The Russian Journal of Transplantation

2074-05062542-0909

IPO Association of Transplantologists

10.23873/2074-0506-2023-15-2-251-265

transplantologiya-778

Research Article

ОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИ

REVIEW ARTICLES AND LECTURES

Главный комплекс гистосовместимости: история открытия, эволюция, строение, значение при трансплантации аллогенных гемопоэтических стволовых клеток

Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells

https://orcid.org/0000-0001-6925-9756

Омарова

Ф. А.

Omarova

F. A.

Феруза Абдулгаджи-кизи Омарова, аспирант, врач-гематолог отделения химиотерапии гемобластозов и трансплантации костного мозга и гемопоэтических стволовых клеток 40% – написание текста рукописи, обзор публикаций по теме статьи

125167, Москва, Новый Зыковский пр-д, д. 4

Feruza A. Omarova, Postgraduate, Hematologist of the Department of Hemoblastosis Chemotherapy, and Bone Marrow and Hematopoietic Stem Cell Transplantation, 40%, writing the text of the manuscript, review of publications on the topic of the article

4 Noviy Zykovskiy Dr., Moscow 125167

firaom@mail.ru

https://orcid.org/0000-0001-9431-8316

Дроков

М. Ю.

Drokov

M. Yu.

Михаил Юрьевич Дроков, канд. мед. наук, врач-гематолог, руководитель сектора научных исследований химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга 30% – разработка концепции и дизайна обзора, редактирование рукописи

125167, Москва, Новый Зыковский пр-д, д. 4

Mikhail Yu. Drokov, Cand. Sci. (Med.), Head of the Sector for Scientific Research in Hemoblastosis Chemotherapy, Hematopoietic Depressions, and Bone Marrow Transplantation, 30%, development of the concept and design of the review, editing the manuscript

4 Noviy Zykovskiy Dr., Moscow 125167

https://orcid.org/0000-0002-0110-3314

Хамаганова

Е. Г.

Khamaganova

E. G.

Екатерина Георгиевна Хамаганова, д-р биол. наук, иммуногенетик, заведующая лабораторией тканевого типирования 30% – разработка концепции и дизайна обзора, редактирование рукописи

125167, Москва, Новый Зыковский пр-д, д. 4

Ekaterina G. Khamaganova, Dr. Sci. (Biol.), Immunogeneticist, Head of the Tissue Typing Laboratory, 30%, development of the concept and design of the review article, editing the manuscript

4 Noviy Zykovskiy Dr., Moscow 125167

ФГБУ «НМИЦ гематологии» МЗ РФРоссияNational Medical Research Center for HematologyRussian Federation

2023

23062023

152251265

2023

Омарова Ф.А., Дроков М.Ю., Хамаганова Е.Г.

Omarova F.A., Drokov M.Y., Khamaganova E.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.jtransplantologiya.ru/jour/article/view/778

Цель. Раскрыть значение главного комплекса гистосовместимости и эволюционной дивергенции человеческих лейкоцитарных антигенов в трансплантации аллогенных гемопоэтических стволовых клеток. Статья посвящена эволюции главного комплекса гистосовместимости и рассмотрению причин его формирования на примере системы распознавания беспозвоночных животных, растений, челюстных позвоночных животных и человека. Раскрыты понятия иммунопептидома и эволюционной дивергенции человеческих лейкоцитарных антигенов и приведены данные об их влиянии на исходы терапии у пациентов с гемобластозами. Раскрыто влияние несовместимости по главному комплексу гистосовместимости на исходы трансплантации.

Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells. The article traces the evolution of the major histocompatibility complex and discusses the reasons for its formation on the example of the recognition system of invertebrates, plants, jawed vertebrates and humans. The concepts of immunopeptidome and human leukocyte antigen evolutionary divergence have been defined; and the data on their impact on the therapy outcomes in patients with hemoblastosis have been presented. The impact of the major histocompatibility complex incompatibility on transplantation outcomes has been disclosed.

главный комплекс гистосовместимостичеловеческий лейкоцитарный антигентрансплантация аллогенных гемопоэтических стволовых клеток

major histocompatibility complexhuman leukocyte antigenallogeneic hematopoietic stem cell transplantation

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The authors declare that there are no conflicts of interest present.