transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2023-15-2-347-358transplantologiya-795Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESВозможности применения ингибиторов матриксных металлопротеиназ при кератопластике в условиях ургентной хирургииThe possibilities of using the inhibitors of matrix metalloproteinases for keratoplastyhttps://orcid.org/0009-0007-5148-1712СироткинаК. В.SirotkinaK. V.

Ксения Валерьевна Сироткина, врач-офтальмолог, аспирант отдела травматологии и реконструктивной хирургии

105062, Москва, Садовая-Черногрязская ул., д. 14/19

Kseniya V. Sirotkina, Ophthalmologist, the Postgraduate of the Eye Trauma and Reconstructive Surgery Department

14/19 Sadovaya-Chernogryazskaya St., Moscow 105062

sirotkina.ksen8@yandex.ruhttps://orcid.org/0000-0002-8394-1038ЧенцоваЕ. В.ChentsovaE. V.

Екатерина Валериановна Ченцова, проф., д-р мед. наук, руководитель отдела травматологии и реконструктивной хирургии

105062, Москва, Садовая-Черногрязская ул., д. 14/19

Ekaterina V. Chentsova, Prof., Dr. Sci. (Med.), Head of the Eye Trauma and Reconstructive Surgery Department

14/19 Sadovaya-Chernogryazskaya St., Moscow 105062

chentsova27@yandex.ruФГБУ «НМИЦ глазных болезней им. Гельмгольца» МЗ РФРоссияHelmholtz National Medical Research Center for Eye DiseasesRussian Federation202314092023153347358Copyright © Сироткина К.В., Ченцова Е.В., 20232023Сироткина К.В., Ченцова Е.В.Sirotkina K.V., Chentsova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/795

Введение. Обзор посвящен актуальной вопросу лечения пациентов с кератолизисом. В нашей статье изучена роль матриксных металлопротеиназ в патогенезе расплавления роговицы и кератотрансплантата, рассмотрен практический опыт применения синтетических ингибиторов металлопротеиназ в офтальмологии и других областях медицины. Длительное время ведется поиск эффективных способов лечения повреждений роговицы различного генеза и профилактики осложнений после ее трансплантации. Ряд исследований показал, что локальный дисбаланс в системе матриксных металлопротеиназ и их ингибиторов, а также состояние иммунной системы в целом могут быть определяющими в исходе ургентной кератопластики. В то же время применение синтетических ингибиторов металлопротеиназ может значительно улучшить результат приживления донорской роговицы. Участие тромбоцитов в регуляции протеолитической системы до конца не изучено. Имеющиеся литературные данные о тромбоцитарно-ассоциированном ингибиторе металлопротеиназ и использовании богатой тромбоцитами плазмы для коррекции коллагенолитической активности ферментов, учитывая терапевтическую эффективность и простоту получения аутологичной богатой тромбоцитами плазмы, представляет большой научный и практический интерес.В статье рассмотрены особенности патогенеза кератолизиса, влияющие на исход ургентной кератопластики, описаны характерные особенности матриксных металлопротеиназ и их ингибиторов, а также уделено внимание богатой тромбоцитами плазме – потенциальному эндогенному источнику тканевого ингибитора матриксных металлопротеиназ.Цель. Оценить возможности применения ингибиторов матриксных металлопротеиназ при кератопластике.Материал и методы. Литературный обзор проведен с использованием отечественной базы данных eLIBRARY. RU и зарубежной поисковой среды PubMed. При написании обзора были отобраны основополагающие статьи с 1985 по 2022 годы.

Introduction. The review is devoted to the actual problem of treating patients with keratolysis. The role of matrix metalloproteinases in the pathogenesis of cornea and corneal graft melting is discussed as well as the practical experience of using synthetic metalloproteinase inhibitors in various branches of medicine and in ophthalmology, in particular. In the field of eye diseases, the search for effective methods for the treatment of corneal injuries of various origins, as well as its post-transplant complications, has been underway for a long time. Recent studies have shown that local imbalance of matrix metalloproteinases and their inhibitors system, as well as the immune system status, may play the main role in the outcome of urgent keratoplasty, and the use of synthetic metalloproteinase inhibitors can significantly improve the biological result of the donor cornea transplant. The role of platelets in the regulation of the proteolytic system has not been fully studied. However, some literature data on the platelet-associated inhibitor of metalloproteinases and the use of platelet-rich plasma to correct the collagenolytic activity of enzymes are of great interest to ophthalmologists, due to therapeutic efficacy and simple method of producing its production the autologous platelet-rich plasma.The present brief literature review covers the pathogenesis and clinical features of keratolysis, factors which can affect the outcome of urgent keratoplasty, describes the features of matrix metalloproteinases, their inhibitors, and the plateletrich plasma as a potential endogenous source of a tissue inhibitor of matrix metalloproteinases.Aim. To evaluate the possibility of using inhibitors of matrix metalloproteinases for keratoplasty based on a literature review.Material and methods. To write the review article, we have made the search in the homeland eLibrary.RU database and in the PubMed resource database to select the articles on the topic published in the period from 1985 to 2022.

роговицакератопластикаматриксные металлопротеиназысинтетические ингибиторы металлопротеиназтромбоцитыапротининcorneakeratoplastymatrix metalloproteinasessynthetic inhibitors of metalloproteinasesplateletsaprotininReferencesCauses of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):144–160. PMID: 33275949 https://doi.org/10.1016/S2214-109X(20)30489-7Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Global Health. 2021;9(2):144–160. https://doi.org/10.1016/S2214-109X(20)30489-7Мороз З.И., Малюгин Б.Э., Горохова М.В., Ковшун Е.В. Результаты кератопластики при фистулах роговицы с использованием УФ-кросслинкинг модифицированного донорского материала. Офтальмохирургия. 2014;(2):29–32.Moroz ZI, Malyugin BE, Gorochova MV, Kovschun EV. UV cross-linked donor corneas for penetrating keratoplasties in corneal perforations. Ophthalmosurgery. 2014;(2):29–32. (In Russ.).Целая Т.В., Ченцова Е.В., Боровкова Н.В. Трансплантация клеток слизистой оболочки полости рта при лечении лимбально-клеточной недостаточности. Трансплантология. 2022;14(1):68–78. https://doi.org/10.23873/2074-0506-2022-14-1-68-78Tselaya TV, Chentsova EV, Borovkova NV. Transplantation of cells of the oral mucosa in the treatment of limbal stem cell deficiency. Transplantologiya. The Russian Journal of Transplantation. 2022;14(1):68–78. (In Russ.). https://doi.org/10.23873/2074-0506-2022-14-1-68-78Чеснокова Н.Б., Безнос О.В. Гидролитические ферменты слезной жидкости в норме и при патологии. Российский офтальмологический журнал. 2012;(4):107–111.Chesnokova NB, Beznos OV. Hydrolytic enzymes in normal and pathologic tear fluid. Russian Ophthalmological Journal. 2012;(4):107–111. (In Russ.).Бржеская И.В., Сомов Е.Е. Коллагенолитическая активность конъюнктивальной жидкости у здоровых людей и больных с асептической язвой роговицы различной этиологии. Клиническая офтальмология. 2018;18(2):77–80. https://doi.org/10.21689/2311-7729-2018-18-2-77-80Brzheskaya IV, Somov EE. Collagenolytic activity of conjunctival fluid in healthy people and patients with aseptic ulcer of the cornea of various etiologies. Clinical ophthalmology. 2018;(2):77–80. (In Russ.). https://doi.org/10.21689/2311-7729-2018-18-2-77-80Нероев В.В., Балацкая Н.В., Ченцова Е.В., Куликова И.Г., Шамхалова Х.М. Особенности локальной и системной продукции провоспалительных, хемоаттрактантных медиаторов и сосудистых факторов роста при пересадках роговицы высокого риска. Иммунопатология, аллергология, инфектология. 2021;(1):20–28. https://doi.org/10.14427/jipai.2021.1.20Neroev VV, Balatskaya NV, Chentsova EV, Kulikova IG, Shamkhalova KhM. Features of local and systemic production of pro-inflammatory, chemoattractant mediators and vascular growth factors in high-risk corneal transplants. Immunopatologiya, allergologiya, infektologiya. 2021;(1):20–28. (In Russ.). https://doi.org/10.14427/jipai.2021.1.20Григоркевич О.С., Мокров Г.В., Косова Л.Ю. Матриксные металлопротеиназы и их ингибиторы. Фармакокинетика и фармакодинамика. 2019;(2):3–16. https://doi.org/10.24411/2587-7836-2019-10040Grigorkevich OS, Mokrov GV, Kosova LYu. Matrix metalloproteinases and their inhibitors. Pharmacokinetics and Pharmacodynamics. 2019;(2):3–16. (In Russ.). https://doi.org/10.24411/2587-7836-2019-10040Ram M, Sherer Y, Shoenfeld Y. Matrix metalloproteinase-9 and autoimmune diseases. J Clin Immunol. 2006;26(4):299–307. PMID: 16652230 https://doi.org/10.1007/s10875-006-9022-6Ram M, Sherer Y, Shoenfeld Y. Matrix metalloproteinase-9 and autoimmune diseases. J Clin Immunol. 2006;26(4):299–307. PMID: 16652230 https://doi.org/10.1007/s10875-006-9022-6Sen Е, Balikoglu-Yilmaz M, Bozdag-Pehlivan S, Sungu N, Nur Aksakal F, Altinok A, et al. Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model. J Ocul Pharmacol Ther. 2010;26(5):399–406. PMID: 20874665 https://doi.org/10.1089/jop.2010.0064Sen Е, Balikoglu-Yilmaz M, Bozdag-Pehlivan S, Sungu N, Nur Aksakal F, Altinok A, et al. Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model. J Ocul Pharmacol Ther. 2010;26(5):399–406. https://doi.org/10.1089/jop.2010.0064El-Shabrawi Y, Ardjomand N, Radner H, Ardjomand N. MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma. J Pathol. 2001;194(20):201–206. PMID: 11400149 https://doi.org/10.1002/1096-9896 (200106) 194 : 2 <201 : : AID - PATH840>3.0.CO;2-OEl-Shabrawi Y, Ardjomand N, Radner H, Ardjomand N. MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma. J Pathol. 2001;194:201–206. PMID: 11400149 https://doi.org/10.1002/1096-9896 (200106) 194 : 2 <201 : : AID -PATH840>3.0.CO;2-OКостылева О.И., Муштенко В.В., Колпаков А.В., Тимофеев Ю.С., Кушлинский Н.Е. Особенности экспрессии матриксных металлопротеиназ и их тканевых ингибиторов при опухолях почки. Лабораторная служба. 2017;6(1):6–13. https://doi.org/10.17116/labs2017616-13Kostyleva OI, Mushtenko VV, Kolpakov AV, Timofeev YS, Kushlinskii NE. Features of expression matrix metalloproteinases, their tissue inhibitors and renal cancer. Laboratory Service. 2017;6(1):6–13. (In Russ.). https://doi.org/10.17116/labs2017616-13Клишо Е.В., Кондакова И.В., Чойнзонов Е.Л. Матриксные металлопротеиназы в онкогенезе. Сибирский онкологический журнал. 2003;(2):62–70.Klisho EV, Kondakova IV, Choynzonov EL. Matriksnye metalloproteinazy v onkogeneze. Siberian journal of oncology. 2003;(2):62–70. (In Russ.).Nakagawa R, Akagi R, Yamaguchi S, Enomoto T, Sato Y, Kimura S, et al. Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model. Connect Tissue Res. 2018;60(4):335–343. PMID: 30345823 https://doi.org/10.1080/03008207.2018.1539082Ryosuke N, Ryuichiro A, Satoshi Y, Takahiro E, Yusuke S, Seiji K, et al. Single vs. repeated matrix metalloproteinase-13 knockdown with intra-articular short interfering RNA administration in a murine osteoarthritis model. Connect Tissue Res. 2018;60(4):335–343. PMID: 30345823 https://doi.org/10.1080/03008207.2018.1539082Orchard J, Massey A, Brown R, Cardon-Dunbar A, Hofmann J. Successful management of tendinopathy with injections of the MMP-inhibitor aprotinin. Clin Orthop Relat Res. 2008;466(7):1625–1632. PMID: 18449616 https://doi.org/10.1007/s11999-008-0254-zOrchard J, Massey A, Brown R, Cardon-Dunbar A, Hofmann J. Successful management of tendinopathy with injections of the MMP-inhibitor aprotinin. Clin Orthop Relat Res. 2008;466(7):1625–1632. PMID: 18449616 https://doi.org/10.1007/s11999-008-0254-zКерчева М.А., Рябова Т.Р., Гусакова А.М., Рябов В.В. Влияние доксициклина на развитие неблагоприятного ремоделирования левого желудочка у пациентов с острым первичным передним инфарктом миокарда с подъемом сегмента ST. Сибирское медицинское обозрение. 2018;1(109):71–78. https:// doi.org/10.20333/2500136-2018-1-71-78Kercheva MA, Ryabova TR, Gusakova AM, Ryabov VV. Influence of doxycycleine on development of unfavorable left ventricular remodeling in patients with acute primary anterior myocardial infarction with ST segment elevation. Siberian Medical Review. 2018;1(109):71–78. (In Russ.). https:// doi.org/10.20333/2500136-2018-1-71-78Zandian M, Rahimian N, Soheilifar S. Comparison of therapeutic effects of topical azithromycin solution and systemic doxycycline on posterior blepharitis. Int J Ophthalmol. 2016;9(7):1016–1019. PMID: 27500111 https://doi.org/10.18240/ijo.2016.07.14Zandian M, Rahimian N, Soheilifar S. Comparison of therapeutic effects of topical azithromycin solution and systemic doxycycline on posterior blepharitis. Int J Ophthalmol. 2016;9(7):1016-1019. PMID: 27500111 https://doi.org/10.18240/ijo.2016.07.14Федосеева Е.В., Ченцова Е.В., Боровкова Н.В., Пономарев И.Н., Власова В.А., Павленко Ю.А. Опыт применения тромбофибринового сгустка богатой тромбоцитами плазмы при язвенном поражении роговицы. Российский офтальмологический журнал. 2021;14(4S):15–21. https://doi.org/10.21516/2072-0076-2021-14-4-supplement-15-21Fedoseeva EV, Chentsova EV, Borovkova NV, Ponomarev IN, Vlasova VA, Pavlenko YuA. Experience of using a thrombofibrin clot of platelet-rich plasma in ulcerative lesions of the cornea. Russian ophthalmological journal. 2021;14(4):15–21. (In Russ.). https://doi.org/10.21516/2072-0076-2021-14-4-supplement-15-21Федосеева Е.В., Ченцова Е.В., Боровкова Н.В., Алексеева И.Б., Романова И.Ю. Морфофункциональные особенности плазмы, богатой тромбоцитами, и ее применение в офтальмологии. Офтальмология. 2018;15(4):388–393. https://doi.org/10.18008/1816-5095-2018-4-388-393Fedoseeva EV, Chentsova EV, Borovkova NV, Alekseeva IB, Romanova IYu. Peculiarities of platelet rich plasma and its application in ophthalmology. Ophthalmology. (In Russ.). 2018;15(4):388– 393. https://doi.org/10.18008/1816-5095-2018-4-388-393Murate T, Yamashita K, Isogai C, Suzuki H, Ichihara M, Hatano S, et al. The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis. Br J Haematol. 1997;99(1):181–189. PMID: 9359522 https://doi.org/10.1046/j.1365-2141.1997.3293146.xMurate T, Yamashita K, Isogai C, Suzuki H, Ichihara M, Hatano S, et al. The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis. Br J Haematol. 1997;99(1):181–189. PMID: 9359522 https://doi.org/10.1046/j.1365-2141.1997.3293146.x.Cooper T, Eisen A, Stricklin G, Welgus H. Platelet-derived collagenase inhibitor: characterization and subcellular localization. Proc Natl Acad Sci USA. 1985;82(9):2779–2783. PMID: 2986137 https://doi.org/10.1073/pnas.82.9.2779Cooper T, Eisen A, Stricklin G, Welgus H. Platelet-derived collagenase inhibitor: characterization and subcellular localization. Proc Natl Acad Sci USA. 1985;82(9):2779–2783. https://doi.org/10.1073/pnas.82.9.2779Ченцова Е.В., Вериго Е.Н., Макаров П.В., Хазамова А.И. Кросслинкинг в комплексном лечении язв роговицы и трансплантата. Российский офтальмологический журнал. 2017;10(3):93–100. https://doi.org/10.21516/2072-0076-2017-10-3-93-100Chentsova EV, Verigo EN, Makarov PV, Khazamova AI. Crosslinking in the complex treatment of corneal ulceration and corneal grafting. Russian Ophthalmological Journal. 2017;10(3):93–100. (In Russ.). https:// doi.org/10.21516/2072-0076-2017-10-3-93-100Simon M, Fellner P, El-Shabrawi Y, Ardjomand N. Influence of donor storage time on corneal allograft survival. Ophthalmology. 2004;111(8):1534–1538. PMID: 15288984 https://doi.org/10.1016/j.ophtha.2003.12.060Simon M, Fellner P, El-Shabrawi Y, Ardjomand N. Influence of donor storage time on corneal allograft survival. Ophthalmology. 2004;111(8):1534–1538. PMID: 15288984 https://doi.org/10.1016/j.ophtha.2003.12.060Armitage W, Goodchild C, Matthew D, Gunn D, Hjortdal J, Lohan P, et al. High-risk corneal transplantation: recent developments and future possibilities. Transplantation. 2019;103(12):2468–2478. PMID: 31765363 https://doi.org/10.1097/TP.0000000000002938Armitage W, Goodchild C, Matthew D, Gunn D, Hjortdal J, Lohan P, et al. High-risk corneal transplantation: recent developments and future possibilities. Transplantation. 2019;103(12):2468-2478. PMID: 31765363 https://doi.org/10.1097/TP.0000000000002938Di Zazzo A, Kheirkhah A, Abud T, Goyal S, Dana R. Management of highrisk corneal transplantation. Surv Ophthalmol. 2017;62(6):816–827. PMID: 28012874 https://doi.org/10.1016/j.survophthal.2016.12.010Di Zazzo A, Kheirkhah A, Abud T, Goyal S, Dana R. Management of highrisk corneal transplantation. Surv Ophthalmol. 2017;62(6):816–827. PMID: 28012874 https://doi.org/10.1016/j.survophthal.2016.12.010Williams KA, Coster DJ. The immunobiology of corneal transplantation. Transplantation. 2007;84(7):806–813. PMID: 17984831 https://doi.org/10.1097/01.tp.0000285489.91595.13Williams KA, Coster DJ. The immunobiology of corneal transplantation. Transplantation. 2007;84(7):806–813. PMID: 17984831 https://doi.org/10.1097/01.tp.0000285489.91595.13Tahvildari M, Emami-Naeini P, Omoto M, Mashaghi A, Chauhan SK, Dana R. Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation. Sci Rep. 2017;7:971. PMID: 28428556 https://doi.org/10.1038/s41598-017-01065-zTahvildari M, Emami-Naeini P, Omoto M, Mashaghi A, Chauhan SK, Dana R. Treatment of donor corneal tis-sue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation. Sci Rep. 2017;7:971. PMID: 28428556 https://doi.org/10.1038/s41598-017-01065-zНероев В.В., Балацкая Н.В., Ченцова Е.В., Шамхалова Х.М. Механизмы иммунорегуляции и трансплантационный иммунитет при пересадках роговицы. Медицинская иммунология. 2020;22(1):61–76. https:// doi.org/10.15789/1563-0625-MOI-1768Neroev VV, Balatskaya NV, Chentsova EV, Shamkhalova KhM. Mechanisms of immune regulation and transplantation immunity in corneal transplants. Med Immunol. 2020;22(1):61–76. (In Russ.). https://doi.org/10.15789/1563-0625-MOI-1768Amouzegar A, Chauhan S, Dana R. Alloimmunity and tolerance in corneal transplantation. J Immunol. 2016;196(10):3983–3991. PMID: 27183635 https://doi.org/10.4049/jimmunol.1600251Amouzegar A, Chauhan S, Dana R. Alloimmunity and tolerance in corneal transplantation. J Immunol. 2016;196(10):3983–3991. PMID: 27183635 https://doi.org/10.4049/jimmunol.1600251Жданова Е.В., Костоломова Е.Г., Волкова Д.Е., Зыков А.В. Клеточный состав и цитокиновый профиль синовиальной жидкости при ревматоидном артрите. Медицинская иммунология. 2022;24(5):1017–1026. https://doi.org/10.15789/1563-0625-CCA-2520Zhdanova EV, Kostolomova EG, Volkova DE, Zykov AV. Сellular composition and cytokine profile of synovial fluid in rheumatoid arthritis. Med Immunol. 2022;24(5):1017–1026. (In Russ.). https://doi.org/10.15789/1563-0625-CCA-2520Coussens M, Werb Z. Matrix metalloproteinases and the development of cancer. Chem Biol. 1996;3(11):895–904. PMID: 8939708 https://doi.org/10.1016/s1074-5521(96)90178-7Coussens M, Werb Z. Matrix metalloproteinases and the development of cancer. Chem Biol. 1996;3(11):895–904. PMID: 8939708 https://doi.org/10.1016/s1074-5521(96)90178-7Fini М, Girard M. Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Invest Ophthalmol Vis Sci. 1990;31(9):1779–1788. PMID: 2170294Fini М, Girard M. Expression of collagenolytic/gelatinolytic metalloproteinases by normal cornea. Invest Ophthalmol Vis Sci. 1990;31(9):1779–88. PMID: 2170294Sambursky R, Davitt W, Latkany R, Tauber S, Starr C, Friedberg M, et al. Sensitivity and specificity of a point-ofcare matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye. JAMA Ophthalmol. 2013;131(1):24–28. PMID: 23307206 https://doi.org/10.1001/jamaophthalmol.2013.561Sambursky R, Davitt W, Latkany R, Tauber S, Starr C, Friedberg M, et al. Sensitivity and specificity of a point-ofcare matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye. JAMA Ophthalmol. 2013;131(1):24–28. PMID: 23307206 https://doi.org/10.1001/jamaophthalmol.2013.561Xue M, Kelvey K, Shen K, Minhas N, March L, Park S, et al. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford). 2014;53(12):2270–2279. PMID: 24982240 https://doi.org/10.1093/rheumatology/keu254Xue M, Kelvey K, Shen K, Minhas N, March L, Park S, et al. Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology (Oxford). 2014;53(12):2270-2279. https://doi.org/10.1093/rheumatology/keu254Арапиев М.У., Ловпаче Д.Н., Слепова О.С., Балацкая Н.В. Исследование факторов регуляции экстраклеточного матрикса и биомеханических свойств корнеосклеральной оболочки при физиологическом старении и первичной открытоугольной глаукоме. Национальный журнал глаукома. 2015;14(4):13–20.Arapiev MU, Lovpache DN, Slepova OS, Balatskaya NV. Investigation of regulatory factors of the extracellular matrix and cornea-scleral biomechanical properties in physiological aging and primary open-angle glaucoma. Nat J Glaucoma. 2015;14(4):13–20. (In Russ.).Gavriovic J, Hembry R, Reynolds J, Murphy G. Tissue inhibitor of metalloproteinases (TIMP) regulates extracellular type I collagen degradation by chondrocytes and endothelial cells. J Cell Science. 1987;87(Pt 2):357–362. PMID: 2821028 https://doi.org/10.1242/jcs.87.2.357Gavriovic J, Hembry R, Reynolds J, Murphy G. Tissue inhibitor of metalloproteinases (TIMP) regulates extracellular type I collagen degradation by chondrocytes and endothelial cells. J Cell Sci. 1987;87(2):357–362. PMID: 2821028 https://doi.org/10.1242/jcs.87.2.357Welgus H, Campbell E, Bar-Shavit Z, Senior R, Teitelbaum S. Human alveolar macrophages produce a fibroblast like collagenase and collagenase like inhibitor. J Clin Invest. 1985;76(1):219–224. PMID: 2991337 https://doi.org/10.1172/JCI111949Welgus H, Campbell E, Bar-Shavit Z, Senior R, Teitelbaum S. Human alveolar macrophages produce a fibroblast like collagenase and collagenase like inhibitor. J Clin Invest. 1985;76(1):219–224. PMID: 2991337 https://doi.org/10.1172/JCI111949Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 1991;5(8):2145-2154. PMID: 1850705 https://doi.org/10.1096/fasebj.5.8.1850705Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 1991;5(8):2145–2154. PMID: 1850705 https://doi.org/10.1096/fasebj.5.8.1850705Holten-Anderson M, Brunner N, Christensen I, Jensen V, Nielsen H. Levels of tissue inhibitor of metalloproteinases-1 in blood transfusion components. Scand J Clin Lab Invest. 2002;62(3):223–230. PMID: 12088341 https://doi.org/10.1080/003655102317475489Holten-Anderson M, Brunner N, Christensen I, Jensen V, Nielsen H. Levels of tissue inhibitor of metalloproteinases-1 in blood transfusion components. Scand J Clin Lab Invest. 2002;62(3):223–230. PMID: 12088341 https://doi.org/10.1080/003655102317475489Cui X, Ma Y, Wang H, Huang J, Li L, Tang J, et al. The anti-photoaging effects of pre- and post-treatment of platelet-rich plasma on UVB-damaged HaCaT keratinocytes. Photochem Photobiol. 2021;97(3):589–599. PMID: 33174201 https://doi.org/10.1111/php.13354Xiao C, Ma Y, Wang H, Huang J, Li L, Tang J, et al. The anti-photoaging effects of pre- and post-treatment of platelet-rich plasma on UVB-damaged HaCaT keratinocytes. Photochem Photobiol. 2021;97(3):589–599. PMID: 33174201 https://doi.org/10.1111/php.13354Li D, Zhou N, Zhang L, Ma P, Pflugfelder SC. Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010;51(11):5623–5629. PMID: 20538995 https://doi.org/10.1167/iovs.09-4992Li D, Zhou N, Zhang L, Ma P, Stephen C. Pflugfelder suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010;51(11):5623–5629. PMID: 20538995 https://doi.org/10.1167/iovs.09-4992Zhang L, Su Z, Zhang Z, Lin J, Li DQ, Pflugfelder SC. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015;133(10):1117–1123. PMID: 26204109 https://doi.org/10.1001/jamaophthalmol.2015.2326Zhang L, Su Z, Zhang Z, Lin J, Li D.-Q, Pflugfelder S. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015;133(10):1117–1123. PMID: 26204109 https://doi.org/10.1001/jamaophthalmol.2015.2326Lee E, Vaughan D, Parikh S, Grodzinsky A, Libby P, Lark M, et al. Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells. Circ Res. 1996;78(1):44–49. PMID: 8603504 https://doi.org/10.1161/01.res.78.1.44Lee E, Vaughan D, Parikh S, Grodzinsky A, Libby P, Lark M, et al. Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells. Circ Res. 1996;78(1):44–49. PMID: 8603504 https://doi.org/10.1161/01.res.78.1.44Chu SC, Yang SF, Lue KH, Hsieh YS, Wu CL, Lu KH. Regulation of gelatinases expression by cytokines, endotoxin, and pharmacological agents in the human osteoarthritic knee. Connect Tissue Res. 2004;45(3):142–150. PMID: 15512768 https://doi.org/10.1080/03008200490506058Shu-Chen C, Shun-Fa Y, Ko-Huang L, Yih-Shou H, Chih-Lung W, Ko-Hsiu L. Regulation of gelatinases expression by cytokines, endotoxin, and pharmacological agents in the human osteoarthritic knee. Connective Tissue Res. 2004;45(3):142– 150. PMID: 15512768 https://doi.org/10.1080/03008200490506058

The authors declare that there are no conflicts of interest present.