transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2023-15-3-359-375transplantologiya-796Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESПатология трансплантата печени в отдаленном посттрансплантационном периодеLiver allograft pathology in the late post-transplant periodhttps://orcid.org/0000-0001-5691-5398ВосканянС. Э.VoskanyanS. E.

Сергей Эдуардович Восканян, член-корреспондент РАН, проф., д-р мед. наук, заместитель главного врача по хирургической помощи – руководитель Центра хирургии и трансплантологии

123098, Москва, ул. Маршала Новикова, д. 23

Sergey E. Voskanyan, Corresponding Member of the Russian Academy of Sciences, Prof., Dr. Sci. (Med.)

23 Marshal Novikov St., Moscow 123098

https://orcid.org/0000-0001-8391-5211СюткинВ. Е.SyutkinV. E.

Владимир Евгеньевич Сюткин, д-р мед. наук, профессор кафедры хирургии с курсами онкохирургии, эндоскопии, хирургической патологии, клинической трансплантологии и органного доноства Медико-биологического университета инноваций и непрерывного образования; ведущий научный сотрудник отделения трансплантации печени

123098, Москва, ул. Маршала Новикова, д. 23

129090, Москва, Большая Сухаревская пл., д. 3

Vladimir E. Syutkin, Dr. Sci. (Med.), Professor of the Surgery Department with the Courses of Oncology, Anesthesiology and Resuscitation, Endoscopy, Surgical Pathology, Clinical Transplantation and Organ Donation, the Medical and Biological University of Innovation and Continuing Education; Leading Researcher, Department for Liver Transplantation

23 Marshal Novikov St., Moscow 123098

3 Bolshaya Sukharevskaya Sq., Moscow 129090

https://orcid.org/0000-0002-1561-6268СушковА. И.SushkovA. I.

Александр Игоревич Сушков, канд. мед. наук, заведующий лабораторией новых хирургических технологий

123098, Москва, ул. Маршала Новикова, д. 23

Alexander I. Sushkov, Cand. Sci. (Med.), Head of Laboratory of New Surgical Technologies

23 Marshal Novikov St., Moscow 123098

sushkov.transpl@gmail.comhttps://orcid.org/0000-0003-2445-7382ВосканянЮ. В.VoskanyanYu. V.

Юлия Владимировна Восканян, врач-гастроэнтеролог поликлиники

123098, Москва, ул. Маршала Новикова, д. 23

Yuliya V. Voskanyan, Gastroenterologist of the Out-patient Department

23 Marshal Novikov St., Moscow 123098

https://orcid.org/0000-0002-1135-7430ВеселковаА. Ю.VeselkovaA. Yu.

Александра Юрьевна Веселкова, врач-патологоанатом патологоанатомического отделения

123098, Москва, ул. Маршала Новикова, д. 23

Alexandra Yu. Veselkova, Pathologist of the Pathology Department

23 Marshal Novikov St., Moscow 123098

ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА РоссииРоссияState Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological AgencyRussian FederationФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России; ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияState Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency; N.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation202314092023153359375Copyright © Восканян С.Э., Сюткин В.Е., Сушков А.И., Восканян Ю.В., Веселкова А.Ю., 20232023Восканян С.Э., Сюткин В.Е., Сушков А.И., Восканян Ю.В., Веселкова А.Ю.Voskanyan S.E., Syutkin V.E., Sushkov A.I., Voskanyan Y.V., Veselkova A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/796

Ежегодно увеличивающееся количество трансплантаций печени и растущая популяция реципиентов, переживших ранний послеоперационный период, определяют актуальность изучения проблемы поздней дисфункции трансплантата. Многообразие возможных морфологических и функциональных нарушений пересаженной печени затрудняет их своевременную диагностику. Более того, у многих пациентов серьезное повреждение ткани трансплантата может длительно протекать без клинических проявлений и отклонений лабораторных параметров.В статье приводится обзор и обобщение имеющихся данных о распространенности, структуре, факторах риска и прогностическом значении различных вариантов патологии печеночных трансплантатов, определяемых при гистологическом исследовании в отдаленные сроки после пересадки.

Annually increasing quantity of liver transplants and the growing population of long-survived recipients determine the relevance of late allograft dysfunction study. Variety of morphological and functional disorders of the transplanted liver complicates their timely diagnostics. Moreover, in some patients, serious graft damage may proceed for a long time without clinical manifestations and laboratory abnormalities.The review summarizes the structure, prevalence, risk factors and prognostic value of different liver allograft pathology determined by histological examination in the long term after transplantation.

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The authors declare that there are no conflicts of interest present.