transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2024-16-1-99-115transplantologiya-859Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESРоль экстракорпоральной перфузии легких при трансплантацииEx vivo lung perfusion in lung transplantationhttps://orcid.org/0000-0001-8177-1170ФабрикаА. П.FabrikaA. P.

Андрей Павлович Фабрика, ассистент кафедры госпитальной хирургии № 2 Института клинической медицины им. Н.В. Склифосовского

119991, Москва, Трубецкая ул., д. 8, стр. 2

Andrey P. Fabrika, Assistant Surgeon of the Department of Hospital Surgery № 2, N.V. Sklifosovsky Institute of Clinical Medicine

8 Bldg. 2 Trubetskaya St., Moscow 119991 

fabrika_a_p@staff.sechenov.ruhttps://orcid.org/0009-0006-9697-672XТычинаЕ. П.TychinaE. P.

Екатерина Павловна Тычина, студент 6 курса лечебного факультета

119991, Москва, Трубецкая ул., д. 8, стр. 2

Ekaterina P. Tychina, 6th year student, General Medicine

8 Bldg. 2 Trubetskaya St., Moscow 119991 

ekaterinn.ty@gmail.comhttps://orcid.org/0000-0001-8877-8076БайрамкуловА. М.BayramkulovA. M.

Анзор Муратович Байрамкулов, студент 6 курса лечебного факультета

119991, Москва, Трубецкая ул., д. 8, стр. 2

Anzor M. Bayramkulov, 6th year student, General Medicine

8 Bldg. 2 Trubetskaya St., Moscow 119991 

anzor.bay.00@mail.ruhttps://orcid.org/0000-0002-9616-1161ТарабринЕ. А.TarabrinE. A.

Евгений Александрович Тарабрин, д-р мед. наук, заведующий кафедрой госпитальной хирургии № 2 Института клинической медицины им. Н.В. Склифосовского; главный научный сотрудник отделения неотложной торакоабдоминальной хирургии

119991, Москва, Трубецкая ул., д. 8, стр. 2

129090, Москва, Большая Сухаревская пл., д. 3

Evgeny A. Tarabrin, Dr. Sci. (Med.) Head of the Department of Hospital Surgery № 2, N.V. Sklifosovsky Institute of Clinical Medicine; Chief Researcher of the Department of Emergency Thoracoabdominal Surgery

8 Bldg. 2 Trubetskaya St., Moscow 119991

Bolshaya Sukharevskaya Sq., Moscow 129090 

tarabrin_e_a@staff.sechenov.ruФГАОУ ВО Первый МГМУ им. И.М. Сеченова МЗ РФ (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова МЗ РФ (Сеченовский Университет); ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University); N.V. Sklifosovsky Research Institute for Emergency MedicineRussian Federation20242203202416199115Copyright © Фабрика А.П., Тычина Е.П., Байрамкулов А.М., Тарабрин Е.А., 20242024Фабрика А.П., Тычина Е.П., Байрамкулов А.М., Тарабрин Е.А.Fabrika A.P., Tychina E.P., Bayramkulov A.M., Tarabrin E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/859Введение

Введение. Во всем мире выполняется недостаточно операций по трансплантации легких. Это происходит вследствие малого количества подходящих (идеальных) доноров, отсутствия возможности использовать легкие от доноров, умерших от остановки сердца, невозможносности выполнения данной технически сложной операции в бедных, развивающихся странах и ряда других причин. В различных зарубежных источниках имеются сведения о повышении числа операций по трансплантации легких за счет использования органов от неидеальных (субоптимальных) доноров. Это стало возможным благодаря применению экстракорпоральной нормотермической перфузии донорских легких.

Цель

Цель. Демонстрация возможностей в оценке, терапии и восстановлении функции неидеальных (субоптимальных) донорских легких благодаря применению методики экстракорпоральной перфузии донорских легких.

Материал и методы

Материал и методы. При написании статьи был произведен анализ научных статей, опубликованных в период с 2003 по 2023 г., на основе баз данных PubMed и Google Scholar по ключевому запросу "ex vivo lung perfusion".

Выводы

Выводы. Методика перфузии легких ex vivo является перспективной и эффективной процедурой для их оценки, восстановления и терапии во время трансплантации. Стремительное развитие технологий, применяемых в данной методике, позволяет увеличить количество легких, пригодных для трансплантации, снизить количество посттрансплантационных осложнений и показатели смертности в листе ожидания.

Introduction

Introduction. The number of lung transplants performed worldwide is not enough because of a shortage of suitable (ideal) donors, missed chances to use lungs from donors who died of cardiac arrest, the lack of resources to perform this technically complex operation in poor, developing countries and due to a number of other reasons.) The world literature sources contain information about an increase in the number of lung transplantations by using organs from non-ideal (suboptimal and marginal) donors. This became possible thanks to the technology of ex vivo normothermic perfusion of donor lungs.

Aim

Aim. To demonstrate the possibilities in the assessment, therapy and restoration of the function of non-ideal (suboptimal and marginal) donor lungs by using the technique of ex vivo lung perfusion.

Material and methods

Material and methods. We reviewed scientific articles published in the period from 2003 to 2023 in the PubMed and Google Scholar databases for the key query "ex vivo lung perfusion".

Conclusion

Conclusion. The ex vivo lung perfusion technique is a promising and effective procedure for lung evaluation, recondition and regeneration for) transplantation. A rapid development of technologies for this treatment modality makes it possible to increase the number of lungs suitable for transplantation, reduce the number of post-transplant complications and mortality rates on the waiting list, and improve the outcomes of lung transplantations.

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The authors declare that there are no conflicts of interest present.