transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2024-16-1-116-134transplantologiya-860Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESТерапевтические средства при аппаратной перфузии донорских органовTherapeutic agents for machine perfusion of donor organshttps://orcid.org/0000-0001-6849-1457РжевскаяО. Н.RzhevskayaO. N.

Ольга Николаевна Ржевская, д-р мед. наук, ведущий научный сотрудник отделения трансплантации почки и поджелудочной железы; профессор; профессор кафедры трансплантологии и искусственных органов

129090, Москва, Большая Сухаревская пл., д. 3

127006, Москва, Долгоруковская ул., д. 4

117997, Москва, ул. Островитянова, д. 1

Olga N. Rzhevskaya, Dr. Sci. (Med.), Leading Researche, Department of Kidney and Pancreas Transplantation; Professor; Professor

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

4 Dolgorukovskaya St., Moscow 127006 

1 Ostrovityanov St., Moscow 117997 

rzhevskayaon@sklif.mos.ruМагилевецВ. М.MagilevetsV. M.

Вячеслав Михайлович Магилевец, д-р мед. наук, профессор

127006, Москва, Долгоруковская ул., д. 4

Vyacheslav M. Magilevets, Dr. Sci. (Med.), Professor 

4 Dolgorukovskaya St., Moscow 127006

https://orcid.org/0000-0002-9239-0645ИсламгазинР. Ш.IslamgazinR. S.

Руслан Шамилевич Исламгазин, студент 4 курса лечебного факультета

127006, Москва, Долгоруковская ул., д. 4

Ruslan Sh. Islamgazin, 4th year Student of the Faculty of General Medicine

4 Dolgorukovskaya St., Moscow 127006

https://orcid.org/0000-0001-5889-8675ЯреминБ. И.YareminB. I.

Екатерина Юрьевна Аносова, врач-клинический ординатор отделения трансплантации печени

129090, Москва, Большая Сухаревская пл., д. 3

117997, Москва, ул. Островитянова, д. 1

Boris I. Yaremin, Assoc. Prof., Cand. Sci. (Med.), Surgeon, Department for Liver Transplantation; Associate Professor 

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

1 Ostrovityanov St., Moscow 117997 

   

yareminbi@sklif.mos.ruhttps://orcid.org/0000-0002-0241-1298АносоваЕ. Ю.AnosovaE. Yu.

Екатерина Юрьевна Аносова, врач-клинический ординатор отделения трансплантации печени

129090, Москва, Большая Сухаревская пл., д. 3

117997, Москва, ул. Островитянова, д. 1

Ekaterina Yu. Anosova, Clinical Resident, Physician, Department for Liver Transplantation

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

1 Ostrovityanov St., Moscow 117997 

anosova.kate@gmail.comhttps://orcid.org/0000-0002-1396-7048БалкаровА. Г.BalkarovA.  G.

канд. мед. наук, заведующий научным отделением трансплантации почки и поджелудочной железы; доцент; заведующий организационно-методическим отделом по трансплантологии

129090, Москва, Большая Сухаревская пл., д. 3

117997, Москва, ул. Островитянова, д. 1

115184, Москва, Большая Татарская ул., д. 30

Aslan G. Balkarov, Cand. Sci. (Med.), Head of the Scientific Department of Kidney and Pancreas Transplantation; Associate Professor of the Department of Transplantology and Artificial Organs; Head of the Organizational and Methodological Department for Transplantology

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

1 Ostrovityanov St., Moscow 117997 

30 Bolshaya Tatarskaya St., Moscow 115184 

balkarovag@sklif.mos.ruhttps://orcid.org/0000-0002-6362-7914НоврузбековМ. С.NovruzbekovM. S.

Мурад Сафтарович Новрузбеков, д-р мед. наук, заведующий научным отделением трансплантации печени; профессор; заведующий

129090, Москва, Большая Сухаревская пл., д. 3

127006, Москва, Долгоруковская ул., д. 4

117997, Москва, ул. Островитянова, д. 1

Murad S. Novruzbekov, Dr. Sci. (Med.), Head of the Scientific Department for Liver Transplantation; Professor; Head 

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

4 Dolgorukovskaya St., Moscow 127006 

1 Ostrovityanov St., Moscow 117997 

novruzbekovms@sklif.mos.ruГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «Российский университет медицины» МЗ РФ; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine; Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical UniversityRussian FederationКафедра трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко» ФГБОУ ВО «Российский университет медицины» МЗ РФРоссияDepartment of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of MedicineRussian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical UniversityRussian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ; ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementRussian Federation202422032024161116134Copyright © Ржевская О.Н., Магилевец В.М., Исламгазин Р.Ш., Яремин Б.И., Аносова Е.Ю., Балкаров А.Г., Новрузбеков М.С., 20242024Ржевская О.Н., Магилевец В.М., Исламгазин Р.Ш., Яремин Б.И., Аносова Е.Ю., Балкаров А.Г., Новрузбеков М.С.Rzhevskaya O.N., Magilevets V.M., Islamgazin R.S., Yaremin B.I., Anosova E.Y., Balkarov A.G., Novruzbekov M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/860Актуальность

Актуальность. Неудовлетворенная потребность в трансплантологической помощи диктует необходимость использования органов от субоптимальных доноров. Аппаратная перфузия, активно развивающаяся в настоящее время, призвана решить данную проблему. В работе рассмотрены современные технологии аппаратной перфузии донорских органов ex vivo и in vivo, которые позволяют улучшить их функции и выполнить успешную пересадку. Также проведен анализ и выявлены наиболее перспективные направления исследований как на животных, так и у человека.

Цель

Цель. Проанализировать опыт применения терапевтических средств при аппаратной перфузии донорских органов.

Материал и методы

Материал и методы. Источники с 2015 по 2023 год, найденные в PubMed, Google Scholar, eLibrary.

Заключение

Заключение. Стремительный прогресс в трансплантации легких, печени и почек позволил использовать трансплантаты от асистолических доноров для пациентов, остро нуждающихся в органах. В свою очередь, эти достижения также подтолкнули к изучению потенциальных терапевтических средств, которые могут быть использованы во время перфузии.

Background

Background. The urgency of the unmet need for transplant care dictates the necessity to use organs from suboptimal donors. Machine perfusion, which is actively developing at the present time, is designated to solve this problem. The literature presents novel technologies of ex vivo and in vivo machine perfusion of donor organs, which make it possible to improve their functions and perform a successful transplant. The most promising areas of research both in animals and in humans may be identified by reviewing the literature sources on this subject.

The aim was to analyze the world experience of using therapeutic agents in machine perfusion of donor organs

Material and methods

Material and methods: sources from 2015 to 2023 found in PubMed, Google Scholar, eLibrary databases

Conclusion

Conclusion. The rapid progress in lung, liver and kidney transplantation has made it possible to use grafts from asystolic donors for patients in urgent need of donor organs. In turn, these advances have also prompted the study of potential therapeutic agents that can be used during perfusion.

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The authors declare that there are no conflicts of interest present.