transplantologiyaТрансплантологияTransplantologiya. The Russian Journal of Transplantation2074-05062542-0909IPO Association of Transplantologists10.23873/2074-0506-2024-16-2-244-259transplantologiya-889Research ArticleОБЗОРНЫЕ СТАТЬИ И ЛЕКЦИИREVIEW ARTICLES AND LECTURESМалоизученные мишени патогенеза ишемически-реперфузионного повреждения при трансплантации печениUnderstudied targets of the ischemia-reperfusion injury pathogenesis in liver transplantationhttps://orcid.org/0000-0002-3799-7698СвищеваП. О.SvishchevaP. O.

Полина Олеговна Свищева, врач-патологоанатом патологоанатомического отделения 

129090, Москва, Большая Сухаревская пл., д. 3

Polina O. Svishcheva, Pathologist-Anatomist, Anatomical Pathology Department

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

svischevapo@sklif.mos.ruhttps://orcid.org/0000-0001-6123-8387КаниболоцкийА. А.KanibolotskiyA. A.

Александр Алексеевич Каниболоцкий, канд. мед. наук, врач-патологоанатом, заведующий патологоанатомическим отделением; заведующий организационно-методическим отделом по патологической анатомии; доцент кафедры морфологии и патологии 

129090, Москва, Большая Сухаревская пл., д. 3

115184, Москва, Большая Татарская ул., д. 30

107564, Москва, Краснобогатырская ул., д. 2, стр. 2

Aleksandr A. Kanibolotskiy, Cand. Sci. (Med.), Pathologist-Anatomist, Head of the Anatomical Pathology Department; Head of the Organizational and Methodological Department of Pathological Anatomy; Associate Professor, Department of Morphology and Pathology

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

30 Bolshaya Tatarskaya St., Moscow 115184 

2 Bldg. 2 Krasnobogatyrskaya St., Moscow 107564 

https://orcid.org/0000-0001-5889-8675ЯреминБ. И.YareminB. I.

Борис Иванович Яремин, доц., канд. мед. наук, врач-хирург и научный сотрудник отделения трансплантации печени; доцент кафедры трансплантологии и искусственных органов; доцент кафедры общей хирургии 

129090, Москва, Большая Сухаревская пл., д. 3

117997, Москва, ул. Островитянова, д. 1

107564, Москва, Краснобогатырская ул., д. 2, стр. 2

Boris I. Yaremin, Assoc. Prof., Cand. Sci. (Med.), Surgeon, Department for Liver Transplantation; Associate Professor of the Department of Transplantology and Artificial Organs; Associate Professor of General Surgery Department

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

1 Ostrovityanov St., Moscow 117997 

2 Bldg. 2 Krasnobogatyrskaya St., Moscow 107564 

yareminbi@sklif.mos.ruhttps://orcid.org/0000-0002-0241-1298АносоваЕ. Ю.AnosovaE. Yu.

Екатерина Юрьевна Аносова, врач-клинический ординатор отделения трансплантации печени; старший лаборант кафедры трансплантологии и искусственных органов

129090, Москва, Большая Сухаревская пл., д. 3

117997, Москва, ул. Островитянова, д. 1

Ekaterina Yu. Anosova, Clinical Resident, Physician, Department for Liver Transplantation; Senior Laboratory Assistant at the Department of Transplantology and Artificial Organs

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

1 Ostrovityanov St., Moscow 117997 

anosova.kate@gmail.comhttps://orcid.org/0009-0003-3228-7325КаринаЯ. С.KarinaYa. S.

Яна Сергеевна Карина, студент 6-го курса лечебного факультета  

127006, Москва, Долгоруковская ул., д. 4

Yana S. Karina, 6th year student of the Faculty of Medicine

4 Dolgorukovskaya St., Moscow 127006 

КазиахмедоваЗ. Г.KaziakhmedovaZ. G.

Заира Гамидовна Казиахмедова, студент 6-го курса Института клинической медицины им. Н.В. Склифосовского

119991, Москва, Трубецкая ул., д. 8, стр. 2

Zaira G. Kaziakhmedova, 6th year student at the Institute of Clinical Medicine named after. N.V. Sklifosovsky

8 Bldg. 2 Trubetskaya St., Moscow 119991 

https://orcid.org/0000-0002-6362-7914НоврузбековМ. С.NovruzbekovM. S.

Мурад Сафтарович Новрузбеков, д-р мед. наук, заведующий научным отделением трансплантации печени; заведующий кафедрой трансплантологии и искусственных органов; профессор кафедры хирургических болезней; профессор кафедры трансплантологии и искусственных органов Научно-образовательного института «Высшая школа клинической медицины им. Н.А. Семашко»

129090, Москва, Большая Сухаревская пл., д. 3

117997, Москва, ул. Островитянова, д. 1

107564, Москва, Краснобогатырская ул., д. 2, стр. 2

119991, Москва, Трубецкая ул., д. 8, стр. 2

Murad S. Novruzbekov, Dr. Sci. (Med.), Head of the Scientific Department for Liver Transplantation; Head of the Department of Transplantology and Artificial Organs; Professor of the Department of Surgical Diseases; Professor of the Department of Transplantology and Artificial Organs, the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine"

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

1 Ostrovityanov St., Moscow 117997 

2 Bldg. 2 Krasnobogatyrskaya St., Moscow 107564 

4 Dolgorukovskaya St., Moscow 127006 

novruzbekovms@sklif.mos.ruГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»РоссияN.V. Sklifosovsky Research Institute for Emergency MedicineRussian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; ГБУ «НИИ организации здравоохранения и медицинского менеджмента ДЗМ»; Московский медицинский университет «Реавиз»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; Research Institute for Healthcare Organization and Medical Management; Moscow Medical University "Reaviz"Russian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ; Московский медицинский университет «Реавиз»РоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University; Moscow Medical University "Reaviz"Russian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical UniversityRussian FederationФГБОУ ВО «Российский университет медицины» МЗ РФРоссияRussian University of MedicineRussian FederationФГАОУ ВО Первый МГМУ им. И.М. Сеченова МЗ РФ (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»; Кафедра трансплантологии и искусственных органов ФДПО ИНОПР ФГАОУ ВО РНИМУ им. Н.И. Пирогова МЗ РФ; Московский медицинский университет «Реавиз»; ФГБОУ ВО «Российский университет медицины» МЗ РФРоссияN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University; Moscow Medical University "Reaviz"; Russian University of MedicineRussian Federation202425062024162244259Copyright © Свищева П.О., Каниболоцкий А.А., Яремин Б.И., Аносова Е.Ю., Карина Я.С., Казиахмедова З.Г., Новрузбеков М.С., 20242024Свищева П.О., Каниболоцкий А.А., Яремин Б.И., Аносова Е.Ю., Карина Я.С., Казиахмедова З.Г., Новрузбеков М.С.Svishcheva P.O., Kanibolotskiy A.A., Yaremin B.I., Anosova E.Y., Karina Y.S., Kaziakhmedova Z.G., Novruzbekov M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.jtransplantologiya.ru/jour/article/view/889Актуальность

Актуальность. Трансплантация печени в настоящее время является самым эффективным методом лечения заболеваний с терминальной стадией печеночной недостаточности. Осложнения связаны чаще всего с исходно тяжелым состоянием пациента, несовершенством методов консервации органов, с самим оперативным пособием и иммунологическими осложнениями. К числу наиболее распространенных осложнений трансплантации относится ишемически-реперфузионное повреждение, которое, в той или иной степени, возникает в каждом трансплантированном органе и ухудшает течение послеоперационного периода. В основе данного процесса лежат сложные патофизиологические механизмы повреждения клеток, возникшие вследствие ишемии и воспаления, вызванного реперфузией.

Цель

Цель. Обобщить современные данные о механизмах развития ишемического реперфузионнного повреждения при трансплантации печени и способах уменьшения неблагоприятных последствий.

Материал и методы

Материал и методы. Проведен анализ данных зарубежных и отечественных экспериментальных и клинических исследований, посвященных вопросам патогенеза ишемического реперфузионного повреждения при трансплантации печени. Поиск литературных данных проводился в международных базах данных (PubMed/MedLine, ResearchGate), а также в научной электронной библиотеке России (eLIBRARY.RU) за период 2020–2024 гг.

Заключение

Заключение. В проанализированных публикациях приводятся различные алгоритмы консервации донорских органов, в том числе с использованием аппаратной перфузии. Заслуживают внимания различные алгоритмы консервации донорских органов, в том числе с использованием аппаратной перфузии.

Background

Background. Liver transplantation is currently the most effective method to treat diseases with end-stage liver failure. Complications are most often associated with the initially severe patient condition, imperfect organ preservation methods, the surgical management per se, and immune system incompetence. The most common complications of transplantation include ischemic reperfusion injury, which occurs to some or another extent in each transplanted organ and worsens the course of the postoperative period. The process is based on complex pathophysiological mechanisms of cell damage due to ischemia and inflammation caused by reperfusion.

Objective

Objective. To summarize current data on the mechanisms of the ischemic reperfusion injury development in liver transplantation and to find the ways to reduce adverse effects.

Material and methods

Material and methods. The analysis of data from foreign and homeland experimental and clinical studies on the pathogenesis of ischemic reperfusion injury in liver transplantation has been performed. The search for literature data was carried out in international databases (PubMed/MedLine, ResearchGate, as well as in the scientific electronic library of Russia (eLibrary.RU) for the period from 2020-2024.

Conclusion

Conclusion. The analyzed publications have provided various algorithms for the preservation of donor organs, including those using machine perfusion.

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The authors declare that there are no conflicts of interest present.