KEY PROBLEMS OF TRANSPLANTATION DEVELOPMENT AND THE OBJECTIVES OF HIGHER MEDICAL EDUCATION
https://doi.org/10.23873/2074-0506-2017-9-3-192-210
Abstract
The article presented here as a Program lecture of the Rector of the First Saint-Petersburg State Medical University n.a. acad. I.P. Pavlov highlights the key problems of modern organ transplantation, and explores the main challenges for medical professional education in this context.
Supporting agencies: RSF, Grant № 17-18-01444, 2017
About the Authors
S. F. Bagnenko
First Saint-Petersburg State Medical University n.a. acad. I.P. Pavlov
Russian Federation
Russian Federation
Sergey F. Bagnenko - Acad. of RAS, Prof., Rector
O. N. Reznik
First Saint-Petersburg State Medical University n.a. acad. I.P. Pavlov
Russian Federation
Russian Federation
References
1. Glyantsev S.P. Phenomenon of Demikhov. Part I. Transplantation in the 1st halt of the XX-th century. «We can not wait for favors from nature...»: I.V. Michurin and T.D. Lysenko (1938–1948). Transplantologiya. 2013;(1):35–41. (In Russian).
2. Bryukhonenko S.S. Artificial blood circulation of the whole organism (dog) with the heart off. In: Proceedings of the Scientific Chemical-Pharmaceutical Institute. 1928;20:44–72. (In Russian).
3. Bagnenko S.F., Moysyuk Ya.G., Reznik O.N. Transplant aspects of brain death. Organizational principles of the activity of the organ harvesting service. Moscow: Triada Publ., 2003. 42 p. (In Russian).
4. Bagnenko S.F., Moysyuk Ya.G., Reznik O.N. Organ donation: methodological recommendations. St. Petersburg, 2004. 52 p. (In Russian).
5. Domínguez-Gil B., Delmonico F.L., Shaheen F.A., et al. The critical pathway for deceased donation: reportable uniformity in the approach to deceased donation. Transpl Int. 2011;24(4):373–378. DOI:10.1111/j.1432-2277.2011.01243.x
6. Domínguez-Gil B., Haase-Kromwijk B., Van Leiden H., et al. Current situation of donation after circulatory death in European countries. Transpl Int. 2011;24(7):676–686. DOI:10.1111/j.1432-2277.2011.01257.x
7. Kootstra G. The asystolic, or nonheartbeating, donor. Transplantation. 1997;63(7):917–921. PMID:9112339
8. Baraski A. Surgical Technique of the Abdominal Organ Procurement, Step by Step. London: Springer, 2009. 184 p.
9. Shumakov V.I., ed. Transplantology: guide. Moscow: Meditsina Publ.; Tula: REPPRONIKS Ltd Publ., 1995. 391 p. (In Russian).
10. Posthumous organ donation: National clinical guidelines. Moscow, 2016. 59 p. Available at: http://transpl.ru/files/rto/possmertnoe_dnorstvo_organov.pdf (In Russian).
11. Humar A., Matas A.J. Payne W.D. Atlas of Organ Transplantation. London: Springer-Verlag Limited, 2006. 333 p.
12. Moisyuk Ya.G. Multi-organ donation in clinical transplantation (organization, methodology, tactics, results and perspectives): Dr. med. sci. diss. Synopsis. Moscow, 1992. 21 p. (In Russian).
13. Exploration and preservation of donor organs: 5 national master class «Tulpskillschool», St. Petersburg, October 16-18, 2014. Available at: http://donor-surgery.org/mc5-prg/ (In Russian).
14. Vidal M.M. Transplant procurement management: Transplant coordination organization model for the generation of donors. In: Transplant Coordination Manual. 2nd ed. Universitat de Barcelona: TPM, 2007. 9–26.
15. Reznik O. On the 25th anniversary of the organ donation center and prospects of transplantology in St. Petersburg: interview. Vrachi SPb. 2014;(9-10(12-13)Oct-Nov):2–3. Available at: http://vrachi-spb.ru/sites/__SITE__/files/field_file/presscentr/gazeta2014-09-10.pdf (In Russian).
16. Bagnenko S.F., Shcherbuk Yu.A., Polushin Yu.S., et al. Causes of a shortage of donor organs and ways to overcome it. Meditsinskiy Akademicheskiy Zhurnal. 2011;11(4):13–24. (In Russian).
17. Gautier S.V., Moysyuk Ya.G., Ibragimova O.S. Organ donation and transplantation in Russian Federation in 2009. 2nd report of National registry. Russian Journal of Transplantology and Artificial Organs. 2010;12(3):6–15. (In Russian). DOI:10.15825/1995-1191-2010-3-6-15
18. Gautier S.V., Khomyakov S.M. Organ donation and transplantation in Russian Federation in 2015. 8th report of National Register. Russian Journal of Transplantology and Artificial Organs. 2016;18(2):6–26. (In Russian). DOI:10.15825/1995-1191-2016-2-6-26
19. Ivanyushkin A.Ya., Popova O.V. The problem of brain death in the discourse of bioethics. Moscow: NB-Media Publ., 2013. 288 p. (In Russian).
20. Kompanje E.J.O., de Groot Y.J., Bakker J. Is organ donation from brain dead donors reaching an inescapable and desirable nadir? Transplantation. 2011;91(11):1177–1180. DOI:10.1097/TP.0b013e3182180567
21. Sheehy E., Conrad S.L., Brigham L.E., et al. Estimating the number of potential organ donors in the United States. N Engl J Med. 2003;349(7):667–674. DOI:10.1056/NEJMsa021271
22. Bagnenko S.F., Polushin Yu.S., Moysyuk Ya.G., et al. Analysis of reasons for organ donor shortage and the main directions of its overcoming. Transplantologiya. 2011;(2-3):10–22. (In Russian).
23. Sprung C.L., Cohen S.L., Sjokvist P., et al. End-of-life practices in European intensive care units: the Ethicus Study. JAMA. 2003;290(6):790–797. DOI:10.1001/jama.290.6.790
24. Wijdicks E.F.M. Brain death. 2nd ed. Oxford University Press, 2011. 264 p.
25. Shemie S. D., Baker A. Uniformity in brain death criteria. Semin Neurol. 2015;35(2):162–168. DOI:10.1055/s-0035-1547538
26. Hanto D.W., Veatch R.M. Uncontrolled donation after circulatory determination of death (UDCDD) and the definition of death. Am J Transplant. 2011;11(7):1351–1352. DOI:10.1111/j.1600-6143.2011.03583.x
27. Sung R.S., Christensen L.L., Leichtman A.B., et al. Determinants of discard of expanded criteria donor kidneys: impact of biopsy and machine perfusion. Am J Transplant. 2008;8(4):783–792. DOI:10.1111/j.1600-6143.2008.02157.x.
28. Manara A.R., Murphy P.G., O'Callaghan G. Donation after circulatory death. Br J Anaesth. 2012;108(1):1108–1121. DOI:10.1093/bja/aer357
29. Garcia C.E., Bramhall S., Mirza D.F. Use of marginal donors. Curr Opin Organ Transplant. 2000;5(2):50–56.
30. Steen S., Ingemansson R., Eriksson L., et al. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg. 2007;83(6):2191–2194. DOI:10.1016/j.athoracsur.2007.01.033
31. Boehnert M.U., Yeung J.C., Bazerbachi F., et al. Normothermic acellular ex vivo liver perfusion reduces liver and bile duct injury of pig livers retrieved after cardiac death. Am J Transplant. 2013;13(6):1441–1449. DOI:10.1111/ajt.12224
32. Op den Dries S., Karimian N., Porte R.J. Normothermic machine perfusion of discarded liver grafts. Am J Transplant. 2013;13(9):2504. DOI:10.1371/journal.pone.0110642
33. Balfoussia D., Yerrakalva D., Hamaoui K., et al. Advances in mahine perfusion graft viability assessment in kidney, liver, pancreas, lung and heart transplant. Exp Clin Transplant. 2012;10(2):87–100. PMID:22432750
34. Warnecke G., Moradiellos J., Tudorache I., et al. Normothermic perfusion of donor lungs for preservation and assessment with the Organ Care System lung before bilateral transplantation: a pilot study of 12 patients. Lancet. 2012;380(9856):1851–1858. DOI:10.1016/S0140-6736(12)61344-0
35. Messer S., Ardehali A., Tsui S. Nor-mothermic donor heart perfusion: current clinical experience and the future. Transpl Int. 2015;28(6):634–642. DOI:10.1111/tri.12361
36. Bagnenko S.F., Dubina M.V., Reznik O.N., et al. Theoretical justification of the concept of rehabilitation of donor organs. Meditsinskiy Akademicheskiy Zhurnal. 2011;11(4):25–40. (In Russian).
37. Bagnenko S.F., Moysyuk Ya.G., Skvortsov A.E., Reznik O.N. Rehabilitation of organ from deceased donors. New preservation trend or new paradigm in transplantology? Russian Journal of Transplantology and Artificial Organs. 2009;11(3):17–29. (In Russian). DOI:10.15825/1995-1191-2009-3-17-29
38. Skvortsov A.E., Loginov I.V., Kukushkin A.A., et al. Normothermic extracorporeal perfusion in situ in deceased organ donors with irreversible cardiac arrest and one hour of asystole. 5-year outcomes of kidney transplantation. Russian Journal of Transplantology and Artificial Organs. 2016;18(3):57–67. DOI:10.15825/1995-1191-2016-3-57-67
39. Skvortsov A.E., Loginov I.V., Kukushkin A.A., et al. Donors with cardiac death: full resource of kidney transplantation. Nephrology (Saint-Petersburg). 2016;20(6):90-100. (In Russian).
40. Reznik O.N., Skvortsov A.E., Lopota A.V., et al. Perfusion device for liver preservation ex vivo before transplantation: first experimental study. Russian Journal of Transplantology and Artificial Organs. 2017;19(1):35–40. (In Russian). DOI:10.15825/1995-1191-2017-1-35-40
41. Whitson B.A., Black S.M. Organ assessment and repair centers: The future of transplantation is near. World J Transplant. 2014;4(2):40–42. DOI:10.5500/wjt.v4.i2.40
42. Black S.M., Whitson B.A. Regional Organ Assessment and Repair Centers (ARC's). Ibnosina J Med Biomed Sci. 2013;5(5):243–246.
43. Baranova A.V., Reznik O.N., Skoblov M.Yu., et al. Prospects for the use of pretransplantation antisense gene therapy of donor organs to suppress apoptosis in the conduct of normothermic isolated ex vivo perfusion. Meditsinskiy Akademicheskiy Zhurnal. 2012;12(4):79–81. (In Russian).
44. Glebova K., Reznik O.N., Reznik A.O., et al. siRNA technology in kidney transplantation: current status and future potential. BioDrugs. 2014;28(4):345-361. DOI:10.1007/s40259-014-0087-0
45. Consortium for Organ Preservation in Europe. Available at: http://www. cope-eu.org/
46. Ul'yankina I.V., Reznik O.N., Moysyuk Ya.G. The use of everolimus in kidney transplantation from expanded criteria donors. Russian Journal of Transplantology and Artificial Organs. 2009;11(4):103–109. (In Russian). DOI:10.15825/1995-1191-2009-4-103-109
47. Ul'yankina I.V., Skvortsov A.E., Anan'ev A.N., et al. First experience in systemic administration of everolimus in renal transplantation from expanded criteria donors in Russian Federation. Russian Journal of Transplantology and Artificial Organs. 2016;18(4):77–86. (In Russian). DOI:10.15825/1995-1191-2016-4-77-86
48. Reznik O.N., Kuz'min D.O., Skvortsov A.E., Reznik A.O. Biobanks are an essential tool for transplantation. History, current state, perspectives. Russian Journal of Transplantology and Artificial Organs. 2016;18(4):123–132. (In Russian). DOI:10.15825/1995-1191-2016-4-123-132
49. Shmeman A.D. Death as a «practical problem». Otechestvennye zapiski. 2013;(5):33–45. (In Russian).
50. Organ donation: problems and development prospects in Russia. 2013. Available at: http://www.levada.ru/2013/10/21/donorstvo-organovproblemy-i-perspektivy-razvitiya-vrossii/ (In Russian).
51. Czerwi ń ski J., Krawczyk A., Łagiewska B., et al. Questionnaire regarding the knowledge of the rules of organ procurement from cadaveric donors for transplantation directed to the directors of medical institutions in Poland. Transplant Proc. 2006;38(1):14–15. DOI:10.1016/j.transproceed.2005.12.015
52. Shcherbuk Yu.A., Bagnenko S.F., Grinenko O.A., et al. Deficiency of donor organs: causes, problems, solutions. Messenger of Anesthesiology and Resuscitation. 2011;8(2):31–42. (In Russian).
53. Van Ittersum F.J., Hendriks L. Organ Donation after Euthanasia. Nat Catholic Bioethics Quart. 2012;12(3):431–438. DOI:10.5840/ncbq201212326
54. Van Dijk G., Giezeman A., Ultee F., Hamers R. Organ donation after active euthanasia in a patient with a neurodegenerative disease. Ned Tijdschr Geneeskd. 2013;157(39):A6548. PMID:24063672
55. Wilkinson D., Savulescu J. Should we allow organ donation euthanasia? Alternatives for maximizing the number and quality of organs for transplantation. Bioethics. 2012;26(1):32–48. DOI:10.1111/j.1467-8519.2010.01811.x
56. Glannon W. The moral insignificance of death in organ donation. Camb Q Healthc Ethics. 2013;22(2):192-202. DOI:10.1017/S0963180112000564
57. Utkin A.I. The influence of the media on the characteristics of social institutions of modern society. Conference Collections of Science publishing centre «Sociosphere». 2017;(4):73–76. (In Russian).
58. Reznik O.N. Organizational and technological basis for obtaining and selecting kidneys for transplantation. Dr. med. sci. diss. Synopsis. Moscow, 2008.
59. p. Available at: http://oldvak.ed.gov.ru/common/img/uploaded/files/vak/announcements/medicin/14-04-2008/ ReznikaON.pdf (In Russian).
60. Mone T.D. The business of organ procurement: organ procurement and preservation. Cur Opin Organ Transplant. 2002;7(1):60–64.
61. Tishchenko P.D. Double helix of life technologization. Epistemology & Philosophy of Science. 2016;2(48):51–53. (In Russian).
62. Fundamentals of the social concept of the Russian Orthodox Church. Ch. XII. Problems of bioethics. Available at: https://mospat.ru/ru/documents/socialconcepts/xii/ (In Russian).
63. Peykova Z.I., Prusak A.I. Fundamentals of the social concept of the Russian Orthodox Church («round table»). Sociological Studies. 2001;(8):96–103. (In Russian).
64. The First All-Russian Scientific Conference «Theology in the Humanities Educational Space». Available at: http://minobrnauki.rf/%D0%BD%D0%BE%D0%B2%D0%BE%D1%81%D1%82%D0%B8/10215 (In Russian).
65. Scientific and theological conference «Comprehension of the problems of life and death in theology, resuscitation and transplantology». St. Petersburg, December 9, 2016. Available at: http://www.bogoslov.ru/text/5152010/index.html (In Russian).
66. The St. Petersburg Theological Academy hosted a scientific and theological conference devoted to the problems of resuscitation and transplantology. Available at: http://www.patriarchia.ru/db/text/4710804.html (In Russian).
Review
For citations:
Bagnenko S.F., Reznik O.N. KEY PROBLEMS OF TRANSPLANTATION DEVELOPMENT AND THE OBJECTIVES OF HIGHER MEDICAL EDUCATION. Transplantologiya. The Russian Journal of Transplantation. 2017;9(3):192-210. https://doi.org/10.23873/2074-0506-2017-9-3-192-210
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