Risk factors for infectious complications after liver transplantation
Abstract
Objective: To determine risk factors for infection in patients after orthotopic liver transplantation.
Material: Retrospective analysis of 215 liver transplantations in the Sklifosofsky Research Institute for Emergency Medicine.
Results: Bleeding from esophageal varices, the presence of refractory ascites, prolonged cold ischemia, reperfusion injury, severe graft, hyperbilirubinemia, as well as a number of comorbidities were found as established reliable risk factors for infectious and septic complications after liver transplantation.
About the Authors
V. A. GulyaevRussian Federation
M. S. Novruzbekov
Russian Federation
A. O. Chugunov
Russian Federation
N. K. Kuznetsova
Russian Federation
S. V. Zhuravel
Russian Federation
References
1. Полухина, О.В. Частота развития и свойства возбудителей инфекционных осложнений у пациентов, перенесших ортотопическую трансплантацию печени / О.В. Полухина, Д.А. Гранов, Т.Н. Суборова // Вестник трансплантологии и искусственных органов. – 2012. – No 4. – С. 27–32.
2. Успешная трансплантация печени пациенту в критическом состоянии / М.Ш. Хубутия, С.В. Журавель, Н.К. Кузнецова, И.В. Александрова // Трансплантология. – 2013. – No 1. – С. 25–27.
3. Pathogenesis of early operative site infections after orthotopic liver transplantation / P.M. Arnow, K.C. Zachary, J.R. Thistlethwaite, [et al.] // Transplantation. – 1998. – Vol. 65, No 11. – P. 1500–1503.
4. Bacterial infection as a complication of liver transplantation: Epidemiology and risk factors / D.L. George, P.M. Arnow, A.S. Fox, [et al.] // Rev Infect Dis. – 1991. – Vol. 13, No 3. – P. 387–396.
5. Major bacterial infections following liver transplantation: A prospective study / C. Lumbreras, M. Lizasoain, E. Moreno, [et al.] // Hepatogastroenterology. – 1992. – Vol. 39, No 4. – P. 362–365.
6. Snydman, D.R. Infection in solid organ transplantation / D.R. Snydman // Transpl Infect Dis . – 1999. – Vol. 1, No 1. – P. 21–28.
7. Bacterial and fungal infections after liver transplantation: An analysis of 284 patients / J.J. Wade, N. Rolando, K. Hayllar, [et al.] // Hepatology. – 1995. – Vol. 21, No 5. – P. 1328–1336.
8. Safdar, N. The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: A systematic review and meta-analysis / N. Safdar, A .Said, M.R. Lucey // Liver Transpl. - 2004. - Vol. 10, No 7. - P. 817-827.
9. Fishman, JA. Infection in solid-organ transplant recipients / J.A. Fishman // N Engl J Med. – 2007. – Vol. 357, No 25. – P.2601–2614.
10. Infections after liver transplantation. An analysis of 101 consecutive cases / S. Kusne, J.S. Dummer, N .Singh, [et al.] // Medicine (Baltim). – 1988. – Vol. 67, No 2. – P.132-143
Review
For citations:
Gulyaev V.A., Novruzbekov M.S., Chugunov A.O., Kuznetsova N.K., Zhuravel S.V. Risk factors for infectious complications after liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2013;(4):6-9. (In Russ.)