CMV-infection in patients after liver transplantation
Abstract
The article presents an analysis of the current state of the problem antiviral therapy CMV-infection in patients undergoing liver transplantation. We retrospectively reviewed the experience of the Moscow Center for liver transplantation in the prevention of cytomegalovirus disease in liver recipients. We describe the clinical examples of different flow CMV-infection in patients after liver transplantation and therapy approaches.
About the Authors
M. Sh. Khubutiya
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
Russian Federation
Russian Federation
V. E. Syutkin
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
Russian Federation
Russian Federation
A. A. Salienko
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
Russian Federation
Russian Federation
M. S. Novruzbekov
N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
Russian Federation
Russian Federation
References
1. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994 / S.A. Staras, S.C. Dollard, K.W. Radford [et al.] // Clin. Infect. Dis. – 2006. – Vol. 43, N.9. – P. 1143–1151.
2. Beam, E. Cytomegalovirus in solid organ transplantation: epidemiology, prevention, and treatment / E. Beam, R.R. Razonable // Curr. Infect. Dis. Rep. – 2012. – Vol. 14, N.6. – P. 633–641.
3. Croen, K.D. Latency of the human herpesviruses / K.D. Croen // Annu. Rev. Med. – 1991. – Vol. 42. – P. 61–67.
4. Stratta, R.J. Defining the risks for cytomegalovirus infection and disease after solid organ transplantation / R.J. Stratta, C. Pietrangeli, G.M. Baillie // Pharmacotherapy. – 2010. – Vol. 30, N.2. – P. 144–157.
5. Razonable, R.R. Epidemiology of cytomegalovirus disease in solid organ and hematopoietic stem cell transplant recipi ents / R.R. Razonable // Am. J. Health Syst. Pharm. – 2005. – Vol. 62, N.8. – Suppl. 1. – S7–S13.
6. Ljungman, P. Definitions of cytomegalovirus infection and disease in transplant recipients / P. Ljungman, P. Griffiths, C. Paya // Clin. Infect. Dis. – 2002. – Vol. 34, N.8. – P.1094–1097.
7. Razonable, R.R. Cytomegalovirus in solid organ transplantation / R.R. Razonable, A. Humar, Practice A.S.T.I.D.C.O. // Am. J. Transplant. – 2013. – Vol. 13, Suppl. 4. – P. 93–106.
8. Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation / C.N. Kotton, D. Kumar, A.M. Caliendo [et al.] // Transplantat. – 2013. – Vol. 96, N.4. – P. 333–360.
9. Gordon, E. Treatment of Ganciclovir-Resistant Cytomegalovirus in Adult Solid Organ Transplant Recipients. Caught Between a Rock and a Hard Place? [Electronic resource] / E. Gordon. – 2013 [cited 2013 November, 1]. – URL: http://www.utexas.edu/pharmacy/divisions/pharmaco/rounds/gordon11-01-13.pdf.
10. Lurain, N.S. Antiviral drug resistance of human cytomegalovirus / N.S. Lurain, S. Chou // Clin. Microbiol. Rev. – 2010. – Vol. 23, N.4. – P. 689–712.
11. Limaye, A.P. Ganciclovir-resistant cytomegalovirus in organ transplant recipients / A.P. Limaye // Clin. Infect. Dis. – 2002. – Vol. 35, N.7. – P. 866–872.
12. Limaye, A.P. Antiviral resistance in cytomegalovirus: an emerging problem in organ transplant recipients /A.P. Limaye // Semin. Respir. Infect. –2002. – Vol. 17, N.4. – P. 265–273.
13. The role of secondary cytomegalovirus prophylaxis for kidney and liver transplant recipients / T. Sullivan, A. Brodginski, G. Patel, S. Huprikar // Transplant. – 2015. – Vol. 99, N.4. – P.855–859.
Review
For citations:
Khubutiya M.Sh., Syutkin V.E., Salienko A.A., Novruzbekov M.S. CMV-infection in patients after liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2015;(2):6-13.
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