PHENOMENON OF DEMIKHOV. At N.V. Sklifosovsky Institute (1960–1986). Paradigm shift in homologous organ transplantation: from overcoming biological incompatibility to artificial immunological tolerance (1960–1970)
https://doi.org/10.23873/2074-0506-2021-13-3-293-308
Abstract
The analysis of literature on experimental and clinical transplantation for the period of the 1968–1969 demonstrated that in the period from 1960 to 1970 the world transplantation saw a paradigm change in the field of homoorgan transplant: instead of overcoming the incompatibility between the donor organ and the recipient's body by using biological and physiological methods to influence the organ, which V.P. Demikhov had been dealing with for many years; surgeons and scientists, first abroad, and then in the USSR started developing and applying the creation of artificial immunological tolerance by using various physical, chemical and biological methods to impact recipient's body. The change of paradigms significantly influenced the implementation of organ transplantation techniques in clinic, including those of vital organs, and the further development of clinical transplantology. The data on the first heart transplants in 1968 and lung transplants in 1963–1970 have been presented.
About the Author
S. P. Glyantsev
A.N. Bakoulev National Medical Research Center for Cardiovascular Surgery; N.A. Semashko National Research Institute of Public Health
Russian Federation
Russian Federation
Sergey P. Glyantsev, Prof., Dr. Sci. (Med.), Head of the Department of the History of Cardiovascular Surgery; Head of the Sector for the History of Medicine and Factography of the Department for the History of Medicine
135 Roublyevskoe Hwy., Moscow 121552
12 Bldg. 1 Vorontsovo Pole St., Moscow 105064
References
1. Natzinger M, Stastny M, Grützmacher P, Sohn M. The history of kidney transplantation. Urologe A. 2016;55(10):1353–1359. PMID: 27518791 https://doi.org/10.1007/s00120-016-0205-3
2. Petrovskiy BV, Solovev GM, Govallo VI, Yarmolinskiy IS, Krylov VS. Peresadka pochki: Biologicheskie i klinicheskie aspekty. Moscow: Meditsina Publ.; Warsaw: Gos. pol'sk. med. Publ.; 1969. (In Russ.).
3. Hardy JD, Moynihan PC, Timmis HH, Chavez CM, Davis JT Jr, Anas P. A case of clinical lung allotransplantation. J Thorac Cardiovass Surg. 1970;60(3):411–426. PMID: 4916119. (In Russ.).
4. Kirpatovskiy ID. Zarubezhnyy opyt transplantatsii organov. Moscow: Meditsina Publ.; 1968. (In Russ.).
5. Barnard KN. Peresadka serdtsa cheloveku. Eksperimental'naya khirurgiya i anesteziologiya. 1969;2:46–51. (In Russ.).
6. Rowe HT. Der Chirurg von Kapstadt. München und Percha: Verlag R.S. Schultz; 1968.
7. Lakatos I. Fal'sifikatsiya i metodologiya nauchno-issledovatel'skikh programm. Moscow; 1995. (In Russ.).
8. Kun T. Struktura nauchnykh revolyutsiy. Moscow: AST Publ.; 2015. (In Russ.).
9. Puchkovkaya NV. (ed.) Problemy gomoplastiki i alloplastiki: materialy 2-y Vsesoyuznoy konferentsii. Kiev: Zdorov’ya Publ.; 1967. (In Russ.).
10. Glyantsev SP. Phenomenon of Demikhov. In the Sklifosovsky Institute (1960–1986). Research Coordination Council of the USSR Healthcare Ministry: Missed opportunities. Part 1 (1963). Transplantologiya. The Russian Journal of Transplantation. 2019;11(3):244–258. (In Russ.). https://doi.org/10.23873/2074-0506-2019-11-3-244-258
11. Glyantsev SP. Phenomenon of Demikhov. In the Sklifosovsky Institute (1960–1986). Research Coordination Council of the USSR Healthcare Ministry: Missed opportunities. Part 2 (1963). Transplantologiya. The Russian Journal of Transplantation. 2019;11(4):330–348. (In Russ.). https://doi.org/10.23873/2074-0506-2019-11-4-330-348
12. Glyantsev SP, Gorelik BM, Werner A. Phenomenon of Demikhov. In the Sklifosovsky Institute (1960–1986). C.N. Barnard and the first clinical heart transplantation (December 3, 1967). V.P. Demikhov and C.N. Barnard: touchpoints. Transplantologiya. The Russian Journal of Transplantation. 2020;12(4):332–352. (In Russ.). https://doi.org/10.23873/2074-0506-2020-12-4-332-352
13. Na poroge ery transplantatsii: reportazh. Nauka i zhizn'. 1968;4:78–95. (In Russ.).
14. Amosov NM. Golosa vremen. Moscow: Vagrius Publ.; 1999. (In Russ.).
15. Dorozinskiy A, Blyuen K-B. Odno serdtse – dve zhizni. Moscow: Mir Publ.; 1969. (In Russ.).
Review
For citations:
Glyantsev S.P. PHENOMENON OF DEMIKHOV. At N.V. Sklifosovsky Institute (1960–1986). Paradigm shift in homologous organ transplantation: from overcoming biological incompatibility to artificial immunological tolerance (1960–1970). Transplantologiya. The Russian Journal of Transplantation. 2021;13(3):293-308. https://doi.org/10.23873/2074-0506-2021-13-3-293-308
Views:
435
