Modification of antidote therapy for poisoning due to massive admission of paracetamol
A. Yu. Simonova,
M. M. Potskhveriya,
M. V. Belova,
K. K. Ilyashenko,
N. E. Stolbova,
Yu. A. Kurilkin https://doi.org/10.23873/2074-0506-2022-14-4-444-451
Abstract
Background. Paracetamol poisoning is common all over the world, including in Russia. In 20–25% of cases, a massive dose of the drug is observed: more than 30–40 g of paracetamol at a time.
The aim of the study was to demonstrate the efficacy of using an increased doses of acetylcysteine in the treatment of a massive paracetamol admission.
Results. Patient G., 22 years old, took 70 tablets (35 g) of paracetamol for suicide 3 hours before admission to the hospital. The blood level of paracetamol 4 hours after taking it was 694.94 µg/mL. Upon admission to the hospital, acetylcysteine administering was started according to a 12-hour scheme. Subsequently, the administration of acetylcysteine was continued according to a 20-hour regimen with an increased dosage at the 2nd stage. Laboratory parameters, including aspartate aminotransferase and alanine aminotransferase, remained within the reference values during hospital stay. Conclusion. The case report we have presented shows the efficacy and expediency of using an increased doses of acetylcysteine in case of massive admission of paracetamol, which contributes to the prevention of the development of severe complications and a favorable course and outcome of the disease.
About the Authors
A. Yu. Simonova
N.V. Sklifosovsky Research Institute for Emergency Medicine; Scientific and Practical Toxicology Center of Federal Medical Biological Agency; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Anastasiya Yu. Simonova, Cand. Sci. (Med.), Leading Researcher, Scientific Department of Acute Poisonings and Somatopsychiatric Disorders; Senior Researcher; Assistant at the Department of Clinical Toxicology
3 Bolshaya Sukharevskaya Sq., Moscow 129090
2/1 Bldg.1 Barrikadnaya St., Moscow 125993
M. M. Potskhveriya
N.V. Sklifosovsky Research Institute for Emergency Medicine; Scientific and Practical Toxicology Center of Federal Medical Biological Agency; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Mikhail M. Potskhveriya, Cand. Sci. (Med.), Head of the Scientific Department of Acute Poisonings and Somatopsychiatric Disorders; Аssociate Professor of the Department of Clinical Toxicology; Toxicologist, Scientific and Practical Toxicology Center of Federal Medical Biological Agency
3 Bolshaya Sukharevskaya Sq., Moscow 129090
2/1 Bldg.1 Barrikadnaya St., Moscow 125993
M. V. Belova
N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Mariya V. Belova, Assoc. Prof., Dr. Sci. (Biol.), Leading Researcher, Scientific Department of Acute Poisonings and Somatopsychiatric Disorders; Аssociate Professor of the Department of Clinical Toxicology
3 Bolshaya Sukharevskaya Sq., Moscow 129090
2/1 Bldg.1 Barrikadnaya St., Moscow 125993
K. K. Ilyashenko
N.V. Sklifosovsky Research Institute for Emergency Medicine; Scientific and Practical Toxicology Center of Federal Medical Biological Agency
Russian Federation
Russian Federation
Kapitalina K. Ilyashenko, Prof., Dr. Sci. (Med.), Scientific Consultant, Scientific Department of Acute Poisonings and Somatopsychiatric Disorders; Leading Researcher
3 Bolshaya Sukharevskaya Sq., Moscow 129090
N. E. Stolbova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Natalya E. Stolbova, Head of the Intensive Care Unit for Emergency Detoxification
3 Bolshaya Sukharevskaya Sq., Moscow 129090
Yu. A. Kurilkin
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Yuriy A. Kurilkin, Laboratory Assistant at the Department of Acute Poisoning and Somatopsychiatric Disorders
3 Bolshaya Sukharevskaya Sq., Moscow 129090
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Review
For citations:
Simonova A.Yu., Potskhveriya M.M., Belova M.V., Ilyashenko K.K., Stolbova N.E., Kurilkin Yu.A. Modification of antidote therapy for poisoning due to massive admission of paracetamol. Transplantologiya. The Russian Journal of Transplantation. 2022;14(4):444-451. https://doi.org/10.23873/2074-0506-2022-14-4-444-451
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