Issues of preparation for implementing uterine transplantation in clinical practice
https://doi.org/10.23873/2074-0506-2023-15-1-79-88
Abstract
The absolute uterine factor infertility is a non-treatable cause of female infertility. Surrogacy has become the only option that allows this group of patients to achieve genetic, although biological motherhood. According to statistics there are more than 30 thousand women of fertile age in Russia who cannot get pregnant due to the absolute uterine factor infertility. The recently emerged possibility of uterine transplantation has become the only treatment for this kind of female infertility.
Prior to the very first clinical study of human uterine transplantation which was carried out in 2013 in Sweden, scientists had conducted systematic studies in animals (rodents, pigs, cattle and primates). The first clinical trial with the uterine transplantation performed resulted in a live birth in September 2014. Currently, cases of successful uterine transplantation in humans have been reported in Sweden, Brazil, USA and Italy. Experience and practice in animal research played a key role in the success of the first clinical study on uterine transplantation. The application of this method is fundamental in the introduction of the scientifically grounded technology of uterine transplantation in Russia.
Aim. Analysis of the problems of the clinical application of the uterine transplantation based on a literature review.
About the Authors
A. M. Polstianoy
Federal Siberian Research Clinical Centre of Federal Medical Biological Agency
Russian Federation
Russian Federation
Aleksey M. Polstianoy - Cand. Sci. (Med.), Head of the Married Couple Health Center
26 Kolomenskaya St., Krasnoyarsk 660037 Russia
K. K. Gubarev
State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency
Russian Federation
Russian Federation
Konstantin K. Gubarev - Cand. Sci. (Med.), Head of the Surgical Department for the Coordination of Human Organ and Tissue Donation
23 Marshal Novikov St., Moscow 123098 Russia
O. Yu. Polstianaya
Federal Siberian Research Clinical Centre of Federal Medical Biological Agency
Russian Federation
Russian Federation
Oksana Yu. Polstianaya - Deputy Chief Physician for Surgery
26 Kolomenskaya St., Krasnoyarsk 660037 Russia
I. V. Rendashkin
Federal Siberian Research Clinical Centre of Federal Medical Biological Agency
Russian Federation
Russian Federation
Ivan V. Rendashkin - Urologist of the Gynecological Department
26 Kolomenskaya St., Krasnoyarsk 660037 Russia
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Review
For citations:
Polstianoy A.M., Gubarev K.K., Polstianaya O.Yu., Rendashkin I.V. Issues of preparation for implementing uterine transplantation in clinical practice. Transplantologiya. The Russian Journal of Transplantation. 2023;15(1):79-88. https://doi.org/10.23873/2074-0506-2023-15-1-79-88
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