Главный комплекс гистосовместимости: история открытия, эволюция, строение, значение при трансплантации аллогенных гемопоэтических стволовых клеток
https://doi.org/10.23873/2074-0506-2023-15-2-251-265
Аннотация
Цель. Раскрыть значение главного комплекса гистосовместимости и эволюционной дивергенции человеческих лейкоцитарных антигенов в трансплантации аллогенных гемопоэтических стволовых клеток.
Статья посвящена эволюции главного комплекса гистосовместимости и рассмотрению причин его формирования на примере системы распознавания беспозвоночных животных, растений, челюстных позвоночных животных и человека. Раскрыты понятия иммунопептидома и эволюционной дивергенции человеческих лейкоцитарных антигенов и приведены данные об их влиянии на исходы терапии у пациентов с гемобластозами. Раскрыто влияние несовместимости по главному комплексу гистосовместимости на исходы трансплантации.
Об авторах
Ф. А. Омарова
ФГБУ «НМИЦ гематологии» МЗ РФ
Россия
Россия
Феруза Абдулгаджи-кизи Омарова, аспирант, врач-гематолог отделения химиотерапии гемобластозов и трансплантации костного мозга и гемопоэтических стволовых клеток
40% – написание текста рукописи, обзор публикаций по теме статьи
125167, Москва, Новый Зыковский пр-д, д. 4
М. Ю. Дроков
ФГБУ «НМИЦ гематологии» МЗ РФ
Россия
Россия
Михаил Юрьевич Дроков, канд. мед. наук, врач-гематолог, руководитель сектора научных исследований химиотерапии гемобластозов, депрессий кроветворения и трансплантации костного мозга
30% – разработка концепции и дизайна обзора, редактирование рукописи
125167, Москва, Новый Зыковский пр-д, д. 4
Е. Г. Хамаганова
ФГБУ «НМИЦ гематологии» МЗ РФ
Россия
Россия
Екатерина Георгиевна Хамаганова, д-р биол. наук, иммуногенетик, заведующая лабораторией тканевого типирования
30% – разработка концепции и дизайна обзора, редактирование рукописи
125167, Москва, Новый Зыковский пр-д, д. 4
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Рецензия
Для цитирования:
Омарова Ф.А., Дроков М.Ю., Хамаганова Е.Г. Главный комплекс гистосовместимости: история открытия, эволюция, строение, значение при трансплантации аллогенных гемопоэтических стволовых клеток. Трансплантология. 2023;15(2):251-265. https://doi.org/10.23873/2074-0506-2023-15-2-251-265
For citation:
Omarova F.A., Drokov M.Yu., Khamaganova E.G. Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells. Transplantologiya. The Russian Journal of Transplantation. 2023;15(2):251-265. https://doi.org/10.23873/2074-0506-2023-15-2-251-265
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