Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells
https://doi.org/10.23873/2074-0506-2023-15-2-251-265
Abstract
Aim. To reveal the significance of the major histocompatibility complex and the human leukocyte antigen evolutionary divergence in transplantation of allogeneic hematopoietic stem cells.
The article traces the evolution of the major histocompatibility complex and discusses the reasons for its formation on the example of the recognition system of invertebrates, plants, jawed vertebrates and humans. The concepts of immunopeptidome and human leukocyte antigen evolutionary divergence have been defined; and the data on their impact on the therapy outcomes in patients with hemoblastosis have been presented. The impact of the major histocompatibility complex incompatibility on transplantation outcomes has been disclosed.
About the Authors
F. A. Omarova
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Feruza A. Omarova, Postgraduate, Hematologist of the Department of Hemoblastosis Chemotherapy, and Bone Marrow and Hematopoietic Stem Cell Transplantation,
40%, writing the text of the manuscript, review of publications on the topic of the article
4 Noviy Zykovskiy Dr., Moscow 125167
M. Yu. Drokov
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Mikhail Yu. Drokov, Cand. Sci. (Med.), Head of the Sector for Scientific Research in Hemoblastosis Chemotherapy, Hematopoietic Depressions, and Bone Marrow Transplantation,
30%, development of the concept and design of the review, editing the manuscript
4 Noviy Zykovskiy Dr., Moscow 125167
E. G. Khamaganova
National Medical Research Center for Hematology
Russian Federation
Russian Federation
Ekaterina G. Khamaganova, Dr. Sci. (Biol.), Immunogeneticist, Head of the Tissue Typing Laboratory,
30%, development of the concept and design of the review article, editing the manuscript
4 Noviy Zykovskiy Dr., Moscow 125167
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For citations:
Omarova F.A., Drokov M.Yu., Khamaganova E.G. Major histocompatibility complex: history of discovery, evolution, structure, significance in transplantation of allogeneic hematopoietic stem cells. Transplantologiya. The Russian Journal of Transplantation. 2023;15(2):251-265. https://doi.org/10.23873/2074-0506-2023-15-2-251-265
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