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Rare cases of primarily infected kidney graft transplantation with the development of purulent complications

https://doi.org/10.23873/2074-0506-2024-16-3-353-363

Abstract

Background. Unexpected transmission of an infectious disease agent with a kidney graft to a recipient is a rare event but it is associated with significant morbidity and mortality, especially when exposed to multidrug-resistant bacteria that have not been eliminated by standard antibiotic prophylaxis.

Objective. To demonstrate the need for immediate removal of a primary infected kidney graft in the event of local purulent complications due to the rapid development of sepsis in immunocompromised patients.

Results. The paper describes a clinical course of the infectious process in two kidney recipients each of whom underwent transplantation of a primary infected graft from a single donor, taking into consideration the transplantectomy timing and the treatment outcomes.

Conclusion. The Case Report shows the need for immediate transplantectomy in a kidney graft recipient when local purulent complications are detected with confirmed primary infection of the graft due to a high risk of the rapid development of sepsis and threat to life.

About the Authors

N. V. Shmarina
N.V. Sklifosovsky Research Institute for Emergency Medicine ; Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical University
Russian Federation

Nonna V. Shmarina, Cand. Sci. (Med.), Surgeon, Senior Researcher, Department of Kidney and Pancreas Transplantation; Associate Professor

3 Bolshaya Sukharevskaya Sq., Moscow 129090  

1 Ostrovityanov St., Moscow 117997 



K. E. Lazareva
N.V. Sklifosovsky Research Institute for Emergency Medicine ; Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine
Russian Federation

Kseniya E. Lazareva, Cand. Sci. (Med.), Endocrinologist, Research Associate, Department of Kidney and Pancreas Transplantation; Associate Professor

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

4 Dolgorukovskaya St., Moscow 127006 



I. V. Dmitriev
N.V. Sklifosovsky Research Institute for Emergency Medicine ; Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical University
Russian Federation

Ilya V. Dmitriev, Dr. Sci. (Med.), Head of the Department of Kidney and Pancreas Transplantation; Associate Professor

3 Bolshaya Sukharevskaya Sq., Moscow 129090  

1 Ostrovityanov St., Moscow 117997 



A. G. Balkarov
N.V. Sklifosovsky Research Institute for Emergency Medicine ; Department of Transplantology and Artificial Organs, N.I. Pirogov Russian National Research Medical University ; Research Institute for Healthcare Organization and Medical Management
Russian Federation

Aslan G. Balkarov, Cand. Sci. (Med.), Head of the Scientific Department of Kidney and Pancreas Transplantation; Associate Professor; Head of the Organizational and Methodological Department for Transplantology

3 Bolshaya Sukharevskaya Sq., Moscow 129090  

1 Ostrovityanov St., Moscow 117997 

30 Bolshaya Tatarskaya St., Moscow 115184 



D. V. Lonshakov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation

Denis V. Lonshakov, Surgeon, Department of Kidney and Pancreas Transplantation

3 Bolshaya Sukharevskaya Sq., Moscow 129090 



N. S. Zhuravel
N.V. Sklifosovsky Research Institute for Emergency Medicine ; Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine
Russian Federation

Nikita S. Zhuravel, Cand. Sci. (Med.), Surgeon, Junior Researcher, Department of Kidney and Pancreas Transplantation; Assistant

3 Bolshaya Sukharevskaya Sq., Moscow 129090 

4 Dolgorukovskaya St., Moscow 127006  



V. V. Smirnova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation

Viktoriya V. Smirnova, Surgeon, Junior Researcher, Department of Kidney and Pancreas Transplantation

3 Bolshaya Sukharevskaya Sq., Moscow 129090 



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For citations:


Shmarina N.V., Lazareva K.E., Dmitriev I.V., Balkarov A.G., Lonshakov D.V., Zhuravel N.S., Smirnova V.V. Rare cases of primarily infected kidney graft transplantation with the development of purulent complications. Transplantologiya. The Russian Journal of Transplantation. 2024;16(3):353-363. https://doi.org/10.23873/2074-0506-2024-16-3-353-363

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ISSN 2074-0506 (Print)
ISSN 2542-0909 (Online)