The impact of С4d deposits in peritubular capillars on living related donor kidney transplantation outcome
Abstract
In the Department of Kidney Transplantation of Petrovsky National Research Centre of Surgery, the investigations of kidney biopsy specimens for С4d started in 2009. The study was performed in 119 patients with impaired function of kidneys allografted from living related donors. The staining for C4d was negative in 85 cases, and positive in 34 cases. The groups were compared on the following parameters: the patient mortality, and allograft loss. Besides, morphologic findings in the biopsy were compared by nature between the groups. There were 6 deaths among 85 patients in Group 1, and 16 deaths among 34 patients in Group 2. Comparative analysis of results, using Fischer's criterion, demonstrated a statistically significant difference in mortality between the groups ( 2 = 4,86, p = 0,0275). As for graft losses, and the nature of assessed morphology findings, they were nearly similar in both groups. Therefore, according to our data, the presence of C4d protein was associated with increased mortality. The differences between the groups in all other parameters were not statistically significant.
About the Authors
V. A. Goryaynov
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
M. M. Kaabak
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
N. N. Babenko
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
M. M. Morozova
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
L. I. Agureeva
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
A. G. Aganesov
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
E. N. Platova
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
O. V. Dymova
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
V. V. Panin
Petrovsky National Research Centre of Surgery, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Goryaynov V.A., Kaabak M.M., Babenko N.N., Morozova M.M., Agureeva L.I., Aganesov A.G., Platova E.N., Dymova O.V., Panin V.V. The impact of С4d deposits in peritubular capillars on living related donor kidney transplantation outcome. Transplantologiya. The Russian Journal of Transplantation. 2016;(1):19-24.
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