Current ways to prevent the development of coronary artery disease of the transplanted heart
https://doi.org/10.23873/2074-0506-2026-18-1-135-144
Abstract
Background. Coronary artery disease of the transplanted heart (CADTH) is the most frequent complication and cause of death in patients living more than a year after heart transplantation (HT). The development of effective methods for CADTH prevention remains one of the urgent tasks of transplantology. Up-do-date methods of ex vivo machine perfusion, which allow the CADTH prevention and ensure longer cardiac allograft survival and function.
Objective. To make a review of promising methods for CADTH prevention to prolong the cardiac allograft survival and function.
Material and methods. Sources from 2000 to 2024, retrieved from PubMed, Google Scholar, eLIBRARY.RU.
Conclusion. Prevention of cardiac graft vasculopathy at early stages, namely during ex vivo machine perfusion, allows reducing the risk of the disease onset in the postoperative period. Machine perfusion of the cardiac graft is not only a way of CADTH prevention, but possibly the key way of prolongation of the graft functioning.
About the Authors
M. Sh. Khubutiya
N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian University of Medicine
Russian Federation
Russian Federation
Mogeli Sh. Khubutiya, Academician of the Russian Academy of Sciences, Prof., Dr. Sci. (Med.), President; Head of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine"
3 Bolshaya Sukharevskaya Sq., Moscow 129090
4 Dolgorukovskaya St., Moscow 127006
R. Sh. Islamgazin
Russian University of Medicine
Russian Federation
Russian Federation
Ruslan Sh. Islamgazin, 6th year Student of the Faculty of Medicine
4 Dolgorukovskaya St., Moscow 127006
O. N. Rzhevskay
N.V. Sklifosovsky Research Institute for Emergency Medicine; Russian University of Medicine
Russian Federation
Russian Federation
Olga N. Rzhevskaya, Dr. Sci. (Med.), Senior Researcher, Department of Kidney and Pancreas Transplantation; Professor of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine"
3 Bolshaya Sukharevskaya Sq., Moscow 129090
4 Dolgorukovskaya St., Moscow 127006
V. M. Magilevets
Russian University of Medicine; Academician V.I. Shumakov National Medical Research Center of Transplantology and Artificial Organs
Russian Federation
Russian Federation
Vyacheslav M. Magilevets, Dr. Sci. (Med.), Professor of the Department of Transplantology and Artificial Organs of the Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine"; Leading Researcher, Department of Anesthesiology and Intensive Care
4 Dolgorukovskaya St., Moscow 127006
1 Shchukinskaya St., Moscow 123182
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Review
For citations:
Khubutiya M.Sh., Islamgazin R.Sh., Rzhevskay O.N., Magilevets V.M. Current ways to prevent the development of coronary artery disease of the transplanted heart. Transplantologiya. The Russian Journal of Transplantation. 2026;18(1):135–144. (In Russ.) https://doi.org/10.23873/2074-0506-2026-18-1-135-144
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