Inflammatory markers and infectious complications in the early postoperative period in orthotopic liver transplantation
https://doi.org/10.23873/2074-0506-2017-9-4-299-305
Abstract
Procalcitonin and c-reactive protein are routine inflammatary markers used in the perioperative period to detect surgical infectious complications. However, a number of studies have demonstrated that these laboratory markers appear less effective in identifying infectious complications in the early postoperative period in patients after liver transplantation, and their predictive power is limited. We hypothesized, that interleukin-6 could be a more reliable and precise marker of the development of infectious complications in this patient population.
About the Authors
O. A. Chugunova
The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9
Belarus
Anesthesiologist and Critical Care Physician of the Anesthesiology and Critical Care Department No. 2 at The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9, Minsk
Belarus
Anesthesiologist and Critical Care Physician of the Anesthesiology and Critical Care Department No. 2 at The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9, Minsk
A. M. Dzyadz'ko
The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9
Belarus
Minsk
Belarus
Minsk
A. E. Shcherba
The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9
Belarus
Minsk
Belarus
Minsk
M. L. Katin
The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9
Belarus
Minsk
Belarus
Minsk
D. Yu. Efimov
The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9
Belarus
Minsk
Belarus
Minsk
A. F. Minov
The Republican Scientific-Practical Center of Organ and Tissue Transplantation at the City Clinical Hospital No. 9
Belarus
Minsk
Belarus
Minsk
References
1. Maddrey W.C., Schiff E.R., Sorrell M.F. Transplantation of the liver. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2001.
2. Zhuravel' S.V., Kuznetsova N.K., Chernen'kaya T.V., Utkina I.I. Transmission of infectious agents from the donor to the recipient. Do we need change in the risk assessment? Transplantologiya. 2015;(1):7–12. (In Russian).
3. Jalan R., Fernandez J., Wiest R., et al. Bacterial infections in cirrhosis: A position statement based on the Conference 2013. J Hepatol. 2014;60(6):1310– 1324. PMID:24530646 DOI:10.1016/j.jhep.2014.01.024
4. Eyraud D., Ayed S., Tanguy M. L., et al. Procalcitonin in liver transplantation: are high levels due to donors or recipients? Critical Care. 2008;12:R85. DOI:10.1186/cc6942
5. Dembic Z. The Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response. Chapter 6: Cytokines of the Immune System: Interleukins. Elsevier, Academic press. 2015: 143–239.
6. Jani A., Chen P. Infections After Solid Organ Transplantation. Medscape. Available at: https://emedicine.medscape.com/article/430550-overview
7. Bone R.C., Balk R.A., Cerra F.B., et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/ SCCM Consensus Conference Committee. American College of Chest Physicians/ Society of Critical Care Medicine. Chest. 1992;101(6):1644–1655. PMID:1303622 DOI:10.1378/chest.101.6.1644
8. Levy M.M., Fink M.P., Marshall J.C., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250–1256. PMID:12682500 DOI:10.1097/01.CCM.0000050454.01978.3B
9. Rhodes A., Evans L.E., Alhazzani W., et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304–377. PMID:28101605 DOI:10.1007/s00134-017-4683-6
10. Mokart D., Merlin M., Sannini A., et al. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anaest. 2005;94(6):767–773. PMID:15849208 DOI:10.1093/bja/aei143
11. Qu J., L X., Liu Y., Wang X. Evaluation of procalcitonin, c-reactive protein, interleukin 6 and serum amyloid as diagnostic biomarkers of bacterial infection in febrile patients. Indian J Med Res. 2015;141(3):315–321. PMID:25963492
12. Lin S, Zhu Y, Huang Z, et al. Interleukin-6 as an early diagnostic marker for bacterial sepsis in patient with liver cirrhosis. J Critical Care. 2015;30(4):732–738. PMID:25891645 DOI:10.1016/j.jcrc.2015.03.031
13. Zant R., Melter M., Knoppke B., et al. Kinetics of Interleukin-6, procalcitonin and c-reactive protein after pediatric liver transplantation. Transplant Proc. 2014;46(10):3507–3510. PMID:25498081 DOI:10.1016/j.transproceed.2014.08.048
14. Dzyadz'ko A.M., Shcherba A.E., Rummo O.O., et al. Paradox: Does liver insufficiency protect the patient? A hypothesis. Transplantologiya. 2017;(1):52–70. (In Russian). DOI:10.23873/2074-0506-2017-9-1-52-70
15. Takeuchi O., Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140(6):805–820. PMID:20303872 DOI:10.1016/j.cell.2010.01.022
16. Olthoff K.M., Kulik L., Samstain B., et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver transplant. 2010.16(8):943–949. PMID:20677285 DOI:10.1002/lt.22091
Review
For citations:
Chugunova O.A., Dzyadz'ko A.M., Shcherba A.E., Katin M.L., Efimov D.Yu., Minov A.F. Inflammatory markers and infectious complications in the early postoperative period in orthotopic liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2017;9(4):299-305. (In Russ.) https://doi.org/10.23873/2074-0506-2017-9-4-299-305
Views:
917
