An acute episode of rhabdomyolysis associated with everolimus and cabergoline intake in a postpartum kidney recipient
https://doi.org/10.23873/2074-0506-2017-9-4-312-316
Abstract
Kidney transplantation is one of the most promising ways to ensure the onset and successful maintenance of pregnancy in patients with end-stage chronic renal disease. A multicomponent drug therapy in such patients creates risks for fetal development, primarily due to the teratogenicity of mTOR receptor inhibitors and mycophenolate. Moreover, the inhibitors of the proliferative signal may have potential drug interactions, which can result in additional complications.
Rhabdomyolysis is one of them. The paper describes the clinical case of an acute episode of reversible rhabdomyolysis in a patient on everolimus therapy.
About the Authors
B. I. YareminRussian Federation
Associate Professor, Cand. Med. Sci., Head of Samara Center for Organ and Tissue Transplantation at the Samara State Medical University
Samara
E. V. Parabina
Russian Federation
Samara
U. V. Maslikova
Russian Federation
Samara
V. E. Aleksandrova
Russian Federation
Samara
References
1. Kandidova I.E. Pregnancy in recipients of renal allograft: Cand. med. sci. diss. Moscow, 2002. 130 p. (In Russian).
2. Andrievskaya T.G., Kutuzova R.I., Karpova V.V. A case of acute renal failure as a result of rhabdomyolysis. Siberian Medical Journal (Irkutsk). 2011;(1):170– 172. (In Russian).
3. Esnazarova G.S., Omarova Kh.S., Shamshidinova M.A., Ordakhanova M.S., Bayzhigitova N.B. Clinical case of rhabdomyoly. Medicine (Almaty). 2016;2(164):55–57. (In Russian).
4. Kulakov V.I., Murashko L.E., Moysyuk Ya.G., et al. Pregnancy and childbirth in women with a transplanted kidney. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2004;(2):27–32. (In Russian).
5. Mironov L.L. Rhabdomyolysis. Emergency medicine. 2006;6(7):7–14. (In Russian).
6. Prokopenko E.I., Nikol'skaya I.G. Pregnancy in female recipients of renal transplant. Almanac of Clinical Medicine. 2014;30:99–107. DOI:10.18786/2072-0505-2014-30-99-107 (In Russian).
7. Murashko L.E., Kandidova I.E., Sukhikh G.T. Kidney disease in pregnant women and pregnancy after kidney transplantation. Moscow, 2012. 202 p. (In Russian).
8. Armenti V.T., Moritz M.J., Cardonick E.H., Davison J.M. Immunosuppression in pregnancy: choices for infant and maternal health. Drugs. 2002;62(16):2361–2375. PMID:12396228
9. Chittka D., Hutchinson J.A. Pregnancy After Renal Transplantation. Transplantation. 2017;101(4):675–678. DOI:10.1097/TP.0000000000001649
10. Brosens I., Pijnenborg R., Benagiano G. Risk of obstetrical complications in organ transplant recipient pregnancies. Transplantation. 2013;96(3):227–233. DOI:10.1097/TP.0b013e318289216e
11. Fiocchi R., D’Elia E., Vittori C., et al. First Report of a Successful Pregnancy in an Everolimus-Treated HeartTransplanted Patient: Neonatal Disappearance of Immunosuppressive Drugs. Am J Transplant. 2016;16(4):1319–1322. DOI:10.1111/ajt.13514
12. Framarino dei Malatesta M, Corona LE, De Luca L, et al. Successful pregnancy in a living-related kidney transplant recipient who received sirolimus throughout the whole gestation. Transplantation. 2011;91(9):e69–e71. DOI:10.1097/TP.0b013e3182154267
Review
For citations:
Yaremin B.I., Parabina E.V., Maslikova U.V., Aleksandrova V.E. An acute episode of rhabdomyolysis associated with everolimus and cabergoline intake in a postpartum kidney recipient. Transplantologiya. The Russian Journal of Transplantation. 2017;9(4):312-316. (In Russ.) https://doi.org/10.23873/2074-0506-2017-9-4-312-316