The role of donor-specifi c anti-HLA antibodies in the development of humoral rejection
https://doi.org/10.23873/2074-0506-2018-10-2-118-125
Abstract
Humoral rejection belongs to severe complications of the post-transplant period. Mechanisms of humoral rejection proceed through antibody formation. Donor specific anti-HLA antibodies (anti-HLA DSAs) damage transplant tissues by activating the complement system, leading to the dysfunction and loss of the transplanted organ. This article describes the clinical case of humoral rejection development with the identification of anti-HLA DSAs, their impact on the risk of coronary artery disease of the transplanted heart, and the graft loss.
About the Authors
L. K. Tkhatl'
Research Institute – Regional Clinical Hospital № 1. n.a. prof. S.V. Ochapovsky; Kuban State Medical University
Russian Federation
Russian Federation
Laura K. Tkhatl' - Cardiologist, Cardiology Department № 3 at RI – RCH № 1. n.a. Prof. S.V. Ochapovsky.
167, 1 May str., Krasnodar 350086; 4, Sedin str., Krasnodar 350063
I. A. Pashkova
Research Institute – Regional Clinical Hospital № 1. n.a. prof. S.V. Ochapovsky; Kuban State Medical University
Russian Federation
Russian Federation
167, 1 May str., Krasnodar 350086; 4, Sedin str., Krasnodar 350063
E. D. Kosmacheva
Research Institute – Regional Clinical Hospital № 1. n.a. prof. S.V. Ochapovsky; Kuban State Medical University
Russian Federation
Russian Federation
167, 1 May str., Krasnodar 350086; 4, Sedin str., Krasnodar 350063
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Review
For citations:
Tkhatl' L.K., Pashkova I.A., Kosmacheva E.D. The role of donor-specifi c anti-HLA antibodies in the development of humoral rejection. Transplantologiya. The Russian Journal of Transplantation. 2018;10(2):118-125. https://doi.org/10.23873/2074-0506-2018-10-2-118-125
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