Cutaneous graft-versus-host reaction in a female patient a year after orthotopic liver transplantation: a case report and a review of literature
https://doi.org/10.23873/2074-0506-2010-0-1-61-67
Abstract
The paper provides a brief overview of the data available in the literature with the discussion of the basic principles of the diagnosis and treatment of a graft-versus-host reaction (GVHR). After orthotopic liver transplantation, the incidence of this complication is 1–3%, mortality is as high as 75%. The paper describes a case of GVHR after liver transplantation, the clinical picture of which shows a preponderance of skin manifestations. Timely diagnosis of this rare complication has allowed the patient to be effectively treated.
About the Authors
Yu. V. Skvortsova
Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology;
Russian Pediatric Clinical Hospital
Russian Federation
Bone Marrow Transplantation Unit
Russian Federation
Bone Marrow Transplantation Unit
O. D. Olisov
N.V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Department of Renal Transplantation
Russian Federation
Department of Renal Transplantation
V. E. Syutkin
N.V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Department of Renal Transplantation
Russian Federation
Department of Renal Transplantation
D. M. Konovalov
Federal Research Clinical Center of Pediatric Hematology, Oncology, and Immunology;
Russian State Medical University
Russian Federation
Russian Federation
A. V. Chzhao
N.V. Sklifosovsky Research Institute of Emergency Care
Russian Federation
Department of Renal Transplantation
Russian Federation
Department of Renal Transplantation
References
1. Taylor A.T., Gibbs P., Bradley J.A. Acute graft versus host disease following liver transplantation: the enemy within. Am J Transpl 2004;4:466–74.
2. Burdick J.F., Vogelsang G.B., Smith W.J. et al. Severe graft-versus-host disease in liver-transplant recipient. N Engl J Med 1988;318:689–91.
3. Perri R., Assi M., Talwalkar J. et al. Graft versus host disease after liver transplantation: a new approach is needed. Liver Transpl 2007;13:1092–9.
4. Taylor A.L., Gibbs P., Key T. et al. Monitoring systemic donor lymphocyte macrochimerism to aid the differential diagnosis of Graft versus host disease following liver transplantation. Transplantation 2004;77:441–6.
5. Smith D.M., Agura E., Netto G. et al. Liver transplant-associated graft-versus-host disease. Transplantation 2003;75:118–26.
6. Au W.Y., Lo C.M., Hawkins B.R. et al. Evan’s syndrome complicating chronic graft versus host disease after cadaveric liver transplantation. Transplantation 2001;72:527–8.
7. Nemoto T., Kubota K., Kita J. et al. Unusual onset of chronic graft-versus-host disease after adult living-related liver transplantation from a homozygous donor. Transplantation 2003;75:733–6.
8. Whitington P.F., Alonso E.M., Piper J.B. et al. Complete lymphoid chimerism and chronic graft-versus-host disease in an infant recipient of a hepatic allograft from a HLAhomozygous parental living donor. Transplantation 1996;62:1516–9.
9. Apperley J., Gluckman E., Grawohl A. Blood and Marrow Transplantation, European School of Haematology, EBMT, 1998.
10. Collins R.H., Anastasi J., Tertappen L.W. et al. Brief-report: donor-derived long-term multilineage hematopoiesis in a liver transplant recipient. N Engl J Med 1993;328:762–5.
11. Peters C., Minkov M., Gadner H. et al. Statement of current majority practices in graff-vwrsus-host disease prophylaxis and treatment in children. Bone marrow transplant 2000;26:405–11.
12. Massenkeil G., Rackwitz S., Genvresse I. et al. Basiliximab is well torerated and effective in the treatment of steroid-refractory acute graft-versus-host disease after allogeneic stem cell transplantation. Bone marrow transplant 2002;30:899–903.
13. Lee S.J., Vogelsang G., Gilman A. et al. A survey of diagnosis, vanagement, and grading of chronic GVHD. Biol Blood and Marrow Transplant 2002;8:32–9.
14. Saroglia E.M., Lanino E., Manfredini L. et al. Mycophenolate mofetil (MMF) as therapy for refractory chronic GVHD (cGVHD) in cildren recciving bone marrow transplantation. Bone marrow transplant 2000;25:1067–71.
Review
For citations:
Skvortsova Yu.V., Olisov O.D., Syutkin V.E., Konovalov D.M., Chzhao A.V. Cutaneous graft-versus-host reaction in a female patient a year after orthotopic liver transplantation: a case report and a review of literature. Transplantologiya. The Russian Journal of Transplantation. 2010;(1):61-67. (In Russ.) https://doi.org/10.23873/2074-0506-2010-0-1-61-67
Views:
802
Email this article 