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Трансплантология

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Лечение возвратной инфекции HCV после трансплантации печени по поводу терминальных стадий хронического гепатита С

https://doi.org/10.23873/2074-0506-2010-0-2-10-17

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Аннотация

В обзоре обсуждаются возможности проведения противовирусной терапии возвратной инфекции вирусного гепатита С (HCV) после трансплантации печени. Проанализированы концепции упреждающей терапии, начатой в первые недели после трансплантации, а также терапии «по факту» гистологического подтверждения активного гепатита и/или фиброза печени. Рассмотрены возможности и ограничения в использовании пегилированных интерферонов и рибавирина в виде монотерапии или комбинированного лечения. Особое внимание уделено роли вирусной кинетики в определении продолжительности предстоящей терапии, в том числе возможности ее продления >12 мес. Представлены аргументы в пользу более благоприятного течения возвратной инфекции HCV у больных, получающих циклоспорин, по сравнению с пациентами, принимающими такролимус.

Об авторах

В. Е. Сюткин
НИИ скорой помощи им. Н.В. Склифосовского
Россия
Владимир Евгеньевич Сюткин


О. И. Андрейцева
НИИ скорой помощи им. Н.В. Склифосовского
Россия


А. В. Козлова
НИИ скорой помощи им. Н.В. Склифосовского
Россия


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Для цитирования:


Сюткин В.Е., Андрейцева О.И., Козлова А.В. Лечение возвратной инфекции HCV после трансплантации печени по поводу терминальных стадий хронического гепатита С. Трансплантология. 2010;(2):10-17. https://doi.org/10.23873/2074-0506-2010-0-2-10-17

For citation:


Syutkin V.E., Andreitseva O.I., Kozlova A.V. Treatment for recurrent HCV infection after liver transplantation for final stages of chronic hepatitis С. Transplantologiya. The Russian Journal of Transplantation. 2010;(2):10-17. (In Russ.) https://doi.org/10.23873/2074-0506-2010-0-2-10-17

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ISSN 2074-0506 (Print)
ISSN 2542-0909 (Online)