Features of formation of the immune response to infection caused by viruses of the Herpesviridae family or viruses of hepatitis C and B in patients after liver transplantation
https://doi.org/10.23873/2074-0506-2012-0-3-33-41
Abstract
We observed 44 patients during the first 2 – 3 weeks after liver transplantation. Depending on the postoperative course all patients were divided into 3 groups: control group consisted of 28 patients without complications, group 1 consisted of 9 patients diagnosed with an opportunistic viral infection; group 2 included 7 patients with the activation of viral hepatitis B or C in liver transplant . We analyzed the results of biochemical and immunological studies in all groups of patients. There were significant differences in changes in immunological parameters in the groups of patients with infection caused by viruses of different families.
About the Authors
V. P. Nikulina
Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
O. I. Andreytseva
Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
V. E. Syutkin
Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
M. A. Godkov
Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
A. V. Сhzhao
Sklifosovsky Research Institute of Emergency Care
Russian Federation
Russian Federation
References
1. Трансплантация органов и тканей в многопрофильном научном центре/подред. М.Ш.Хубутия. – М. : АирАрт, 2011. – 420 с.
2. Иммунологические исследования при трансплантации печени: роль в дифференциальной диагностике инфекционного воспалительного процесса и острого отторжения / В. П. Никулина [и др.] // Рос. аллерг. жур. – 2011. – №4, вып. 1. – С. 262–264.
3. Hammerich, L. Role of IL-17 and Th17 cells in liver diseases [Электронный ресурс] / L. Hammerich, F. Heymann, F. Tacke // Clin.Dev. Immunol. – 2011. – Режим доступа: http://www.ncbi.nlm. nih.gov / pmc / articles / PMC3010664 /
4. Th17 responses and host defense against microorganisms: an overview / F.L. Van de Veerdonk [et al.] // BMB Rep. – 2009. – Vol. 42 (12). – P. 776–787.
5. Dendritic cell inhibition is connected to exhaustion of CD8+ T cell polyfunctionality during chronic hepatitis C virus infection / I.G. Rodrigue-Gervais [et al.] // J. Immunol. – 2010. – Vol. 184 (6). – P. 3134–3144.
6. Immunomodulation by hepatitis C virus-derived proteins: targeting human dendritic cells by multiple mechanisms / D.K. Krishnadas [et al.] // Int. Immunol. – 2010. – Vol. 22 (6). – P. 491–502.
7. Schneider-Schaulies, S. Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression / S. Schneider-Schaulies, U. Dittmer // J. Gen. Virol. – 2006. – Vol. 87 (Pt. 6). – P. 1423–1438.
8. Increased hepatitis C virus (HCV) – specific CD4+CD25+regulatory T-lymphocytes and reduced HCV-specific CD4+ T cell response in HCVinfected patients with normal versus abnormal alanine aminotransferase levels / F. Bolacchi [et al.] // Clin. Experiment. Immunol. – 2006. – Vol. 144 (2). – P. 188–196.
9. Circulating Toll-like receptor (TLR) 2, TLR4, and regulatory T cells in patients with chronic hepatitis C / J.P. Wang [et al.] // APMIS. – 2010. – Vol. 118 (4). – P. 261–270.
10. Ярилин, А. А. Транскрипционные регуляторы дифференцировки Т-хелперов. Обзор / А.А. Ярилин // Иммунология. – 2010. – №3. – С. 153–162.
11. Abbas, A. K. Basic Immunology. Function and Disordes of the Immune System / A. K. Abbas, A.H. Lichtman. – 3rd ed. – Philadelphia : Sanuders, 2009. – 322 p.
12. Increased hepatitis C virus (HCV) – specific CD4+CD25+regulatory T-lymphocytes and reduced HCVspecific CD4+ T cell response in HCVinfected patients with normal versus abnormal alanine aminotransferase levels / F. Bolacchi [et al.] // Clin. Exp. Immunol. – 2006. – Vol. 144 (2). – P. 188–196.
13. Preferential loss of Th17 cells is associated with CD4 T cell activation in patients with 2009 pandemic H1N1 swineorigin influenza A infection / T. J. Jiang [et al.] // Clin. Immunol. – 2010. – Vol. 137 (3). – P. 303–310.
14. Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism / A. Benson [et al.] // J. Immunol. – 2012. – Vol. 188 (2). – P. 800–810.
15. Ярилин, А. А. Основы иммунологии / А. А. Ярилин. – М. : Медицина, 1999. – 607 с.
16. Пинегин, Б.В. Макрофаги: свойства и функции / Б.В. Пинегин, М. И. Карсонова // Иммунология. – 2009. – №4. – С. 241–249.
17. Nel, A. E. Активация Т-лимфоцитов, опосредованная рецептором антигена. Часть II. Роль сигнальных каскадов в дифференцировке Т-лимфоцитов, анергии, иммунологическом старении; их значение для иммунотерапии / A.E. Nel, N. Slaughter // Аллергология и иммунология. – 2004. – Т. 5, №2. – С. 233–248.
18. Organ Transplantation / eds. F. P. Stuart, M. M. Abecassis, D. B. Kaufman. – 2nd ed. – Georgetown, Texas : Landes Bioscience, 2003. – 619 p.
19. Симонова, А. В. Фенотип лимфоцитов при инфекционных заболеваниях человека / А. В. Симонова // Иммунология. – 2002. – №5. – С. 310–313.
20. Hepatitis C virus (HCV) – specific CD8+ cells produce transforming growth factor beta that can suppress HCVspecific T-cell responses / N. Alatrakchi [et al.] // J. Virol. 2007. – Vol. 81 (1). – P. 5882–5892.
21. Cross-recognition of HLA DR4 alloantigen by virus-specific CD8+ T cells: a new paradigm for self-nonselfrecognition / M. Rist [et al.] // Blood. – 2009. – Vol. 114 (11). – P. 2244–2253.
22. Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation / J.P. Casazza [et al.] // J.Exp. Med. – 2006. – Vol. 203 (13). – P. 2865–2877.
23. Пащенков, М. В. Выявление и характеризация цитолитических CD8+ и CD4+ Т-клеток / М. В. Пащенков, Н.Е. Муругина, Б. В. Пинегин // Иммунология. – 2010. – №1. – С. 4–12.
24. Пащенков, М. В. Изучение условий дифференцировки CD4+- цитотоксических Т-лимфоцитов / М. В. Пащенков, Б. В. Пинегин // Рос. аллерг. жур. – 2011. – №4, вып. 1. – С. 284–286.
Review
For citations:
Nikulina V.P., Andreytseva O.I., Syutkin V.E., Godkov M.A., Сhzhao A.V. Features of formation of the immune response to infection caused by viruses of the Herpesviridae family or viruses of hepatitis C and B in patients after liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2012;(3):33-41. (In Russ.) https://doi.org/10.23873/2074-0506-2012-0-3-33-41
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