Use of cadaver skin in the treatment of wounds
A. V. Sachkov,
N. V. Borovkova,
E. A. Zhirkova,
A. S. Mironov,
V. S. Borisov,
T. G. Spiridonova,
I. N. Ponomarev,
A. V. Svishchev https://doi.org/10.23873/2074-0506-2018-10-4-327-335
Abstract
The article has analyzed the world experience and main trends in the preparation of cadaveric skin for use in the treatment of patients with wounds of various etiologies. The history of the question is described from the first attempts of transplantation of the native skin to the creation of specialized banks of allogenic decellularized tissue grafts. Presented are the modern approaches of donor material conservation, specifically, to the principle and topical question: whether the viability of the cells should be preserved in the graft, or it is more efficient to transplant the skin devoid of cellular elements. The advantages and disadvantages of lyophilized grafts have been described, namely the possibility of longterm storage, but loss of elasticity, after rehydration. The methods of cryoconservation of cutaneous allografts, their properties, and acceptable methods of sterilization have been discussed. A perspective technology of graft decellularization has been assessed and the methodologies of their manufacturing have briefly been presented.
About the Authors
A. V. Sachkov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Aleksey V. Sachkov – Cand. Med. Sci., Head of the Scientific Department of Acute Thermal Injury
3 Bolshaya Sukharevskaya Sq., Moscow 129090
N. V. Borovkova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Natal’ya V. Borovkova – Dr. Med. Sci., Head of the Scientific Department of Biotechnologies and Tranfusiology
3 Bolshaya Sukharevskaya Sq., Moscow 129090
E. A. Zhirkova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Elena A. Zhirkova – Cand. Med. Sci., Researcher of the Department of Acute Thermal Injury
3 Bolshaya Sukharevskaya Sq., Moscow 129090
A. S. Mironov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Aleksandr S. Mironov – Cand. Med. Sci., Head of the Department for Tissue Preservation and Transplant Production
3 Bolshaya Sukharevskaya Sq., Moscow 129090
V. S. Borisov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Valeriy S. Borisov – Cand. Med. Sci., Senior Researcher of the Department of Acute Thermal Injury
3 Bolshaya Sukharevskaya Sq., Moscow 129090
T. G. Spiridonova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Tamara G. Spiridonova – Dr. Med. Sci., Scientific Consultant of the Department of Acute Thermal Injury
3 Bolshaya Sukharevskaya Sq., Moscow 129090
I. N. Ponomarev
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Ivan N. Ponomarev – Cand. Med. Sci., Researcher of the Department of Biotechnologies and Tranfusiology
3 Bolshaya Sukharevskaya Sq., Moscow 129090
A. V. Svishchev
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Aleksandr V. Svishchеv – Chief Specialist of the Department for Organizing and Conducting Clinical Trials and Researches
3 Bolshaya Sukharevskaya Sq., Moscow 129090
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Review
For citations:
Sachkov A.V., Borovkova N.V., Zhirkova E.A., Mironov A.S., Borisov V.S., Spiridonova T.G., Ponomarev I.N., Svishchev A.V. Use of cadaver skin in the treatment of wounds. Transplantologiya. The Russian Journal of Transplantation. 2018;10(4):327-335. https://doi.org/10.23873/2074-0506-2018-10-4-327-335
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