Xenotransplantation: history, problems and development prospects
V. A. Gulyaev,
M. Sh. Khubutiya,
M. S. Novruzbekov,
A. S. Mironov,
O. D. Olisov,
K. N. Lutsyk,
S. V. Zhuravel,
K. M. Magomedov,
R. B. Akhmetshin,
B. I. Yaremin https://doi.org/10.23873/2074-0506-2019-11-1-37-54
Abstract
The paper reviews the milestones and prerequisites in the history of the emergence and development of xenotransplantation. The currently existing barriers (immunological, infectious, genetic, ethical, and regulatory) to the development of this organ and tissue transplantation type have been studied. Available data on theoretical research and experimental studies have been reviewed. The prospects for performing xenotransplantation in various combination of species have been assessed. The forms and variants of the xenograft rejection reaction have been described. Genetic engineering approaches to overcoming xenoimmunological incompatibility are described. An assessment is made of ways to overcome existing barriers and prospects for the further development of xenotransplantation as a scientific section of transplantology.
About the Authors
V. A. Gulyaev
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Vladimir A. Gulyaev - Dr. Med. Sci., Leading Researcher of the Kidney and Pancreas Transplantation Department
3 Bolshaya Sukharevskaya Sq., Moscow 129090
M. Sh. Khubutiya
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Mogeli Sh. Khubutiya - Acad. of RAS, Prof., Dr. Med. Sci., President
3 Bolshaya Sukharevskaya Sq., Moscow 129090
M. S. Novruzbekov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Murad S. Novruzbekov - Dr. Med. Sci., Head of the Scientific Liver Transplantation Department
3 Bolshaya Sukharevskaya Sq., Moscow 129090
A. S. Mironov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Aleksandr S. Mironov - Cand. Med. Sci., Head of the Department for Tissue Preservation and Transplant Production
3 Bolshaya Sukharevskaya Sq., Moscow 129090
O. D. Olisov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Oleg D. Olisov - Cand. Med. Sci., Senior Researcher of the Liver Transplantation Department
3 Bolshaya Sukharevskaya Sq., Moscow 129090
K. N. Lutsyk
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Konstantin N. Lutsyk - Cand. Med. Sci., Head of the Operating Theatre of the City Center for Liver Transplantation
3 Bolshaya Sukharevskaya Sq., Moscow 129090
S. V. Zhuravel
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Sergey V. Zhuravel - Dr. Med. Sci., Head of the Scientific Department of Anesthesiology and Intensive Care for Organ Transplantation
3 Bolshaya Sukharevskaya Sq., Moscow 129090
K. M. Magomedov
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Kubay M. Magomedov - Surgeon of the Operating Theatre of the City Center for Liver Transplantationat
3 Bolshaya Sukharevskaya Sq., Moscow 129090
R. B. Akhmetshin
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Ravil’ B. Akhmetshin - Surgeon of the Operating Theatre (for Organ Transplantation)
3 Bolshaya Sukharevskaya Sq., Moscow 129090
B. I. Yaremin
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Boris I. Yaremin - Cand. Med. Sci., Assistant Professor, Surgeon of the Operating Theatre of the City Center for Liver Transplantation
3 Bolshaya Sukharevskaya Sq., Moscow 129090
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Review
For citations:
Gulyaev V.A., Khubutiya M.Sh., Novruzbekov M.S., Mironov A.S., Olisov O.D., Lutsyk K.N., Zhuravel S.V., Magomedov K.M., Akhmetshin R.B., Yaremin B.I. Xenotransplantation: history, problems and development prospects. Transplantologiya. The Russian Journal of Transplantation. 2019;11(1):37-54. https://doi.org/10.23873/2074-0506-2019-11-1-37-54
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