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Трансплантология

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Биомаркеры толерантности и иммунологический мониторинг при трансплантации печени

https://doi.org/10.23873/2074-0506-2020-12-2-126-134

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Аннотация

Введение. В обзоре обобщены имеющиеся в литературе сведения о клинических и лабораторных показателях, позволяющих прогнозировать развитие операционной толерантности у реципиентов печени после полной отмены иммуносупрессивной терапии.

Цель обзора – выявить возможные биомаркеры толерантности у реципиентов печени с успешной полной отменой иммуносупрессии для последующего внедрения в повседневную клиническую практику. С позиций прогностической значимости оценены клеточные, гуморальные и молекулярные маркеры операционной толерантности реципиентов печени, которым была полностью отменена иммуносупрессивная терапия без развития дисфункции трансплантата. Обоснована необходимость проведения проспективных исследований для выявления биомаркеров, позволяющих до начала или в процессе снижения иммуносупрессии выявить реципиентов печени, у которых возможна полная ее отмена. 

Об авторах

В. Е. Сюткин
ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия

Владимир Евгеньевич Сюткин, д-р мед. наук, ведущий научный сотрудник



Н. В. Боровкова
ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия

Наталья Валерьевна Боровкова, д-р мед. наук, заведующая научным отделением биотехнологий и трансфузиологии



М. С. Новрузбеков
ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия

Мурад Сафтарович Новрузбеков, д-р мед. наук, заведующий научным отделением трансплантации печени



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Для цитирования:


Сюткин В.Е., Боровкова Н.В., Новрузбеков М.С. Биомаркеры толерантности и иммунологический мониторинг при трансплантации печени. Трансплантология. 2020;12(2):126-134. https://doi.org/10.23873/2074-0506-2020-12-2-126-134

For citation:


Syutkin V.E., Borovkova N.V., Novruzbekov M.S. Biomarkers of tolerance and immunological monitoring in liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2020;12(2):126-134. https://doi.org/10.23873/2074-0506-2020-12-2-126-134

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ISSN 2074-0506 (Print)
ISSN 2542-0909 (Online)