Predictive value of serum cytokine level in the assessment of complications after liver transplantation
https://doi.org/10.23873/2074-0506-2021-13-1-33-40
Abstract
Introduction. One of the urgent tasks in modern transplantology is the search of biomarkers for predicting and early diagnosis of graft dysfunction.
Objective. The study objective was to determine the biomarkers of liver graft dysfunction.
Material and methods. We have examined 19 recipients who underwent liver transplantation and 36 healthy blood donors. Levels of 7 serum cytokines were measured by multiparametric fluorescence analysis with magnetic microspheres (xMAP technology, Luminex 200, USA). Statistical analysis was carried out by methods of nonparametric statistics. To determine the predictive value of the test, a ROC-analysis was performed.
Results and discussion. We found that the interleukin-8 level was 3.6 times higher in recipients with liver graft dysfunction compared to those who had an uneventful postoperative course. The diagnostic sensitivity of the test was 75%, the specificity was 91%, and negative predictive value was 84.6.
Conclusion. Serum interleukin-8 measurement provides a biomarker for early predicting a post-transplant liver graft dysfunction development
About the Authors
A. Yu. Maksimova
Ural State Medical University
Russian Federation
Russian Federation
Arina Yu. Maksimova, Junior Researcher of Central Research Laboratory, Department of General Pathology
3 Repin St., Ekaterinburg 620028
E. N. Bessonova
Sverdlovsk Regional Clinical Hospital № 1
Russian Federation
Russian Federation
Elena N. Bessonova, Dr. Sci. (Med.), Head of Gastroenterology Department
185 Volgogradskaya St., Ekaterinburg 620102
V. V. Bazarnyy
Ural State Medical University
Russian Federation
Russian Federation
Vladimir V. Bazarnyy, Dr. Sci. (Med.), Professor of the Department of Clinical Laboratory Diagnostics and Bacteriology
3 Repin St., Ekaterinburg 620028
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Review
For citations:
Maksimova A.Yu., Bessonova E.N., Bazarnyy V.V. Predictive value of serum cytokine level in the assessment of complications after liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2021;13(1):33-39. https://doi.org/10.23873/2074-0506-2021-13-1-33-40
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