Иммунные механизмы в патогенезе острого перитонита
https://doi.org/10.23873/2074-0506-2023-15-1-89-97
Аннотация
Острое воспаление брюшины – перитонит – часто развивается после ранения полых внутренних органов, некроза кишечника, несостоятельности анастомоза или опухолевых процессов. Последующее микробное загрязнение брюшной полости приводит к инфекции, в ответ на которую активируются иммунные механизмы. Патогенез воспалительных процессов в брюшной полости и их особенности во многом определены строением и функциональными возможностями брюшины, а также ее тесной связью с сальником. В разрешении перитонита важным моментом является сохранение баланса цитокинов, активности иммуноцитов и комплемента, функционирующих в иммунных лимфоидных скоплениях брюшины и сальника, и их содружественное действие в ходе воспаления. В обзоре представлены данные о строении и функции брюшины и сальника, роли нейтрофильного, макрофагального, лимфоцитарного звеньев иммунной системы, а также про- и противовоспалительных цитокинов и комплемента в развитии и прекращении острого воспаления в брюшной полости.
Об авторе
Г. В. Булава
ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского ДЗМ»
Россия
Россия
Галина Владимировна Булава, д-р мед. наук, научный консультант лаборатории клинической иммунологии
129090, Россия, Москва, Большая Сухаревская пл., д. 3
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Рецензия
Для цитирования:
Булава Г.В. Иммунные механизмы в патогенезе острого перитонита. Трансплантология. 2023;15(1):89-97. https://doi.org/10.23873/2074-0506-2023-15-1-89-97
For citation:
Bulava G.V. Immune mechanisms in the pathogenesis of acute peritonitis G.V. Bulava. Transplantologiya. The Russian Journal of Transplantation. 2023;15(1):89-97. https://doi.org/10.23873/2074-0506-2023-15-1-89-97
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