Clinical case of disseminated histoplasmosis in a kidney graft recipient
https://doi.org/10.23873/2074-0506-2024-16-2-197-208
Abstract
Introduction. Histoplasmosis is not an endemic form of fungal infection in Russia; its sporadic cases are mainly associated with the import of the fungus from endemic countries. We consider it necessary to demonstrate a rare case of the disseminated histoplasmosis development in a kidney transplant recipient.
Objective. Demonstration of a case of the disseminated histoplasmosis development in a kidney transplant recipient.
Results. The clinical manifestations of the disease were described; the affected organs were macroscopically and histologically studied, which made it possible to diagnose disseminated histoplasmosis.
Conclusions. This case prompts being on alert to potential occurrence of fungal infections, including non-endemic ones, in patients receiving immunosuppressive therapy.
About the Authors
P. G. Titova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Galina P. Titova, Prof., Dr. Sci. (Med.), Head of the Scientific Department of Pathological Anatomy
3 Bolshaya Sukharevskaya Sq., Moscow 129090
N. V. Shmarina
N.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Nonna V. Shmarina, Cand. Sci. (Med.), Senior Researcher, Surgeon, the Department of Kidney and Pancreas Transplantation; Associate Professor of the Department of Transplantology and Artificial Organs
3 Bolshaya Sukharevskaya Sq., Moscow 129090
1 Ostrovityanov St., Moscow 117997
K. E. Lazareva
N.V. Sklifosovsky Research Institute for Emergency Medicine; Scientific and Educational Institute "N.A. Semashko Higher School of Clinical Medicine", Russian University of Medicine
Russian Federation
Russian Federation
Kseniya E. Lazareva, Cand. Sci. (Med.), Endocrinologist at the Department of Kidney and Pancreas Transplantation; Associate Professor of the Department of Transplantology and Artificial Organs
3 Bolshaya Sukharevskaya Sq., Moscow 129090
Dolgorukovskaya St., Moscow 127006
G. A. Nefedova
N.V. Sklifosovsky Research Institute for Emergency Medicine
Russian Federation
Russian Federation
Galina A. Nefedova, Cand. Sci. (Med.), Senior Researcher of the Pathological Anatomy Department
3 Bolshaya Sukharevskaya Sq., Moscow 129090
I. V. Dmitriev
N.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Ilya V. Dmitriev, Dr. Sci. (Med.), Head of the Department of Kidney and Pancreas Transplantation; Associate Professor of the Department of Transplantology and Artificial Organs
3 Bolshaya Sukharevskaya Sq., Moscow 129090
1 Ostrovityanov St., Moscow 117997
A. G. Balkarov
N.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical Management
Russian Federation
Russian Federation
Aslan G. Balkarov, Cand. Sci. (Med.), Head of the Scientific Department of Kidney and Pancreas Transplantation; Associate Professor of the Department of Transplantology and Artificial Organs; Head of the Organizational
3 Bolshaya Sukharevskaya Sq., Moscow 129090
1 Ostrovityanov St., Moscow 117997
30 Bolshaya Tatarskaya St., Moscow 115184
References
1. Araúz AB, Papineni P. Histoplasmosis. Infect Dis Clin North Am. 2021;35(2):471–491. PMID: 34016287 https://doi.org/10.1016/j.idc.2021.03.011
2. Wheat LJ, Azar MM, Bahr NC, Spec A, Relich RF, Hage C. Histoplasmosis. Infect Dis Clin North Am. 2016;30(1):207–227. PMID: 26897068 https://doi.org/10.1016/j.idc.2015.10.009
3. Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current concepts in the epidemiology, diagnosis, and management of histoplasmosis syndromes. Semin Respir Crit Care Med. 2020;41(1):13–30. PMID: 32000281 https://doi.org/10.1055/s-0039-1698429
4. Azar MM, Hage CA. clinical perspectives in the diagnosis and management of histoplasmosis. Clin Chest Med. 2017;38(3):403–415. PMID: 28797485 https://doi.org/10.1016/j.ccm.2017.04.004
5. Lipnitsky AV, Markin AM, Surkova RS, Victorov DV, Toporkov AV. Molecular diagnostics of histoplasmosis. Problems of Particularly Dangerous Infections. 2019;(3):14–18. (In Russ.). https://doi.org/10.21055/0370-1069-2019-3-14-18
6. Prokhvatilova EV, Tkachenko GA, Ledeneva ML, Polovetz NV, Belitskaya LI, Plekhanova NG, et al. The perspective of application of sets of reagents for diagnostic of histoplasmosis using polymerase chain reaction in laboratory practice. Clinical Laboratory Diagnostics. 2017;62(7):426–431. (In Russ.). https://doi.org/10.18821/0869-2084-2017-62-7426-431
7. Jawale PM, Gulwani HV. Histoplasmosis presenting as laryngeal ulcer in a postrenal transplant male: an unusual case from India. Mycol Med. 2017;27(4):573–576. https://doi.org/10.1016/j.mycmed.2017.06.003
8. Popova AY, Toporkov AV, Lipnitsky AV, Polovets NV, Viktorov DV. Spread of especially dangerous mycoses in the world. Journal of microbiology, epidemiology and immunobiology. 2016;(3):120–126. (In Russ.). https://doi.org/10.36233/0372-9311-2016-3-120-126
9. Taylor M, Ghodasara A, Ismail A, Gauhar U, El-Kersh K. Disseminated histoplasmosis in an immunocompetent patient after COVID-19 pneumonia. Cureus. 2021;13(8):e17269. PMID: 3454049 https://doi.org/10.7759/cureus.17269
10. Tobón AM, Gómez BL. Pulmonary histoplasmosis. Mycopathologia. 2021;186(5):697–705. PMID: 34498137 https://doi.org/10.1007/s11046-02100588-4
11. Oladele RO, Ayanlowo OO, Richardson MD, Denning DW. Histoplasmosis in Africa: an emerging or a neglected disease? PLoS Negl Trop Dis. 2018;12(1):e0006046. PMID: 29346384 https://doi.org/10.1371/journal.pntd.0006046
12. Bongomin F, Kwizera R, Denning DW. Getting histoplasmosis on the map of international recommendations for patients with advanced HIV disease. J Fungi (Basel). 2019;5(3):80. PMID: 31480775 https://doi.org/10.3390/jof5030080
13. Ocansey BK, Kosmidis C, Agyei M, Dorkenoo AM, Ayanlowo OO, Oladele RO, et al. Histoplasmosis in Africa: Current perspectives, knowledge gaps, and research priorities. PLoS Negl Trop Dis. 2022;16(2):e0010111. PMID: 35202403 https://doi.org/10.1371/journal.pntd.0010111
Review
For citations:
Titova P.G., Shmarina N.V., Lazareva K.E., Nefedova G.A., Dmitriev I.V., Balkarov A.G. Clinical case of disseminated histoplasmosis in a kidney graft recipient. Transplantologiya. The Russian Journal of Transplantation. 2024;16(2):197-208. https://doi.org/10.23873/2074-0506-2024-16-2-197-208
Views:
278
Email this article 